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PHF2 encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. Zusätzlich bieten wir Ihnen PHF2 Antikörper (38) und viele weitere Produktgruppen zu diesem Protein an.
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these results demonstrate that PHF2 histone demethylase (zeige MBD2 Proteine) controls adipogenic gene expression during differentiation.
PHF2 enhances osteoblast differentiation by demethylating Runx2 (zeige RUNX2 Proteine), while suppressor of variegation 3-9 homolog 1 (SUV39H1 (zeige SUV39H1 Proteine)) inhibits bone formation by methylating it.
Arid5b (zeige ARID5B Proteine) recruits Phf2 to the promoter region of Sox9 (zeige SOX9 Proteine) target genes and stimulates H3K9me2 demethylation of these genes.
Data from PHF2 knockout mice suggest that PHF2 plays roles in both adipogenesis and neonatal growth/weight gain; PHF2 interacts with promoter region of CEBPA (CCAAT-enhancer binding protein alpha (zeige CEBPA Proteine)) gene and demethylates histones in chromatin.
histone H3K4 trimethylation by a homeodomain of PHF2 modulates histone demethylation
PHF2 (zeige PHF1 Proteine) acts as a tumor suppressor in association with p53 (zeige TP53 Proteine) in cancer development and ensures p53 (zeige TP53 Proteine)-mediated cell death in response to chemotherapy.
PHF2 (zeige PHF1 Proteine) is likely to repress rDNA transcription by competing with PHF8 (zeige PHF8 Proteine) for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1 (zeige SUV39H1 Proteine).
JARID1B (zeige KDM5B Proteine) and PHF2 (zeige PHF1 Proteine) are overexpressed in esophageal squamous cell carcinoma (ESCC) and they may play crucial roles in the course of ESCC initiation and/or progression
the crystal structures of PHF2 (zeige PHF1 Proteine) Jumonji (zeige JARID2 Proteine) domain in the absence and presence of additional exogenous metal ions were determined.
Differential association of alterations in FANCC (zeige FANCC Proteine) and PTCH1 (zeige PTCH1 Proteine) with that of PHF2 (zeige PHF1 Proteine), XPA (zeige XPA Proteine) and two breast cancer susceptibility genes (BRCA1/BRCA2 (zeige BRCA2 Proteine)) in the two age groups suggests differences in their molecular pathogenesis.
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
PHD finger protein 2
, polycomb-like protein 1
, t-complex testis-expressed 3
, centromere protein 35
, jumonji C domain-containing histone demethylase 1E
, lysine-specific demethylase PHF2
, PHD finger protein 8
, lysine-specific demethylase phf2