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Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels.
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we systematically evaluating RCC (zeige XRCC1 Antikörper) risk-associated SNPs indentified from previous GWAS in a Chinese population, finding that one SNP located in PDZD2 and two SNPs located in ITPR2 (zeige ITPR2 Antikörper) were ccRCC-risk associated in Chinese population.
The DNA copy number variations disrupt PDZD2 and GOLPH3 (zeige GOLPH3 Antikörper) genes predominantly expressed in placenta, and it may represent a novel risk factor for recurrent miscarriage.
This study does not support the association of PDZD2, GOLPH3 (zeige GOLPH3 Antikörper), and MTMR12 (zeige MTMR12 Antikörper) genes with schizophrenia.
the first reported multi-PDZ protein (zeige INADL Antikörper) that is processed by proteolytic cleavage to generate a secreted peptide containing two PDZ (zeige INADL Antikörper) domains
The mitogenic effect of secreted PDZD2 was concentration-dependent, and was associated with a slight inhibition of the insulin (zeige INS Antikörper) promoter activity at high sPDZD2 concentrations.
Results show that a novel pancreatic developmental factor, PDZD2, is sufficient to promote the proliferation of human fetal PPCs (zeige PPCS Antikörper) while limiting differentiation of ICCs into islet/endocrine cells.
sPDZD2 sensitized mutant p53 (zeige TP53 Antikörper)-positive DU145 cells and wild-type p53 (zeige TP53 Antikörper)-positive MCF-7 cells to apoptosis induction through genotoxic stress imposed by sub-lethal concentration of hydrogen peroxide
PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization.
Results provide the first evidence that Pdzd2 is required for normal regulation of basal insulin (zeige INS Antikörper) secretion.
These findings reveal that Pdzd2 and p11 (zeige S100A10 Antikörper) play collaborative roles in regulation of Na(V)1.8 (zeige SCN10A Antikörper) expression in sensory neurons.
Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.
PDZ domain containing 3
, PDZ domain-containing protein 2
, PDZ domain-containing protein 3
, activated in prostate cancer protein
, plakophilin-related armadillo repeat protein-interacting PDZ protein