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PDZK1 encodes a PDZ domain-containing scaffolding protein. Zusätzlich bieten wir Ihnen PDZK1 Proteine (6) und PDZK1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal PDZK1 Primary Antibody für ICC, IF - ABIN152917
Lan, Silver: Fenofibrate induces a novel degradation pathway for scavenger receptor B-I independent of PDZK1. in The Journal of biological chemistry 2005
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Human Monoclonal PDZK1 Primary Antibody für IHC (p), ELISA - ABIN562170
Walker, MacLeod, Williams, Cameron, Smyth, Langdon: Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. in Gynecologic oncology 2007
These findings have provided first lines of evidences that PDZK1 expression is negatively correlated with SHP-1 activation and poor clinical outcomes in clear cell renal cell carcinoma (ccRCC) . PDZK1 was identified as a novel tumor suppressor in ccRCC by negating SHP-1 activity
HNF1alpha (zeige HNF1A Antikörper), which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 transcription.
a PDZK1 single nucleotide polymorphism rs12129861 was found to be significantly associated with gout susceptibility (meta-analysis)
PDZK1 was defined as an independent prognostic factor for both OS and DFS (zeige FST Antikörper). These findings indicated that low level of PDZK1 could predict poor clinical outcome in patients with ccRCC.
Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 (zeige SLC9A3 Antikörper) dysfunction observed in the inflamed intestine.
PARP (zeige COL11A2 Antikörper) regulates estradiol-mediated cell growth by controlling the ER/IGF-1R (zeige IGF1R Antikörper)/PDZK1 axis.
PDZK1, negatively regulates 5-HT2AR endocytosis and has no effect upon 5-HT2AR-mediated ERK1/2 phosphorylation.
Described is a structure of D-AKAP2 (zeige AKAP10 Antikörper) in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta (zeige SUCLA2 Antikörper)-strand to PDZK1.
PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability.
Correlation between PDZK1, Cdc37 (zeige CDC37 Antikörper), Akt (zeige AKT1 Antikörper) and breast cancer malignancy: the role of PDZK1 in cell growth through Akt (zeige AKT1 Antikörper) stabilization by increasing and interacting with Cdc37 (zeige CDC37 Antikörper)
These results suggest that the PDZ domain (zeige INADL Antikörper) of PICK1 (zeige PICK1 Antikörper) directly interacts with calcineurin B (zeige CAN Antikörper) in osteoclast progenitor cells and promotes osteoclast differentiation through activation of calcineurin-NFAT (zeige NFATC1 Antikörper) signaling.
PDZK1 has novel SR-BI (zeige SCARB1 Antikörper)-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 suppression of VSM cell proliferation via an inhibitory interaction with Bcr (zeige BCR Antikörper)
Data show that interaction of the inducible nitric oxide synthase (iNOS (zeige NOS2 Antikörper)) C-terminus with the PDZ (zeige INADL Antikörper) domains of EBP50 (zeige SLC9A3R1 Antikörper) protein or Pdzk1 protein CAP70 resulted greater nitric oxide (NO) synthesis.
PDZK1 regulates intracellular trafficking of Oatp1a1 (zeige Slco1a1 Antikörper).
PDZK1(NHERF3) is entirely non-raft associated with lipid rafts in brush border membrane fractions of NHE3 (zeige SLC9A3 Antikörper).
NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.
SR-BI (zeige SCARB1 Antikörper) and PDZK1 protein and mRNA expression levels fell rapidly in primary hepatocyte cultures, indicating this system does not adequately mimic hepatocytes in vivo for analysis of the PDZK1 dependence of SR-BI (zeige SCARB1 Antikörper).
the localization of PDZK1 on hepatocyte cell surface membranes in vivo is dependent on its PDZ4 domain and the presence of SR-BI (zeige SCARB1 Antikörper).
The impairment of the absorptive function of the inflamed colon in the IL-10 (zeige IL10 Antikörper)(-/-) mouse, in spite of unaltered NHE3 (zeige SLC9A3 Antikörper) expression and localization, is accompanied by the downregulation of the NHE3 (zeige SLC9A3 Antikörper)-regulatory PDZ (zeige INADL Antikörper) adaptors NHERF2 (zeige SLC9A3R2 Antikörper) and PDZK1.
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PDZ domain containing 1
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3-like
, CFTR-associated protein of 70 kDa
, Na(+)/H(+) exchange regulatory cofactor NHE-RF3
, PDZ-containing kidney protein 1
, na/Pi cotransporter C-terminal-associated protein 1
, sodium-hydrogen exchanger regulatory factor 3
, Na(+)/H(+) exchanger regulatory factor 3
, PDZ domain-containing protein 1
, PDZK1-like protein
, C-terminal linking and modulating protein
, C-terminal-linking and modulating protein
, dietary Pi-regulated RNA-1