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PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family.
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CDK1 (zeige CDK1 ELISA Kits)-mediated mitotic phosphorylation of PDZ-binding kinase is involved in cytokinesis and inhibits its oncogenic activity.
Data suggest that T-LAK cell-originated protein kinase (TOPK) might play a pivotal role in breast cancer invasion and metastasis.
our study provide convincing evidences that FoxM1 (zeige FOXM1 ELISA Kits)-regulated PBK exerts oncogenic activities towards HCC via the activation of beta-Catenin (zeige CTNNB1 ELISA Kits) pathway.
High TOPK expression is associated with liver cancer.
The role of T-LAK cell-originated protein kinase directly promotes metastasis of colorectal cancer by modulating p53-related protein kinase.
TOPK protein and transcriptional levels of FOXM1 (zeige FOXM1 ELISA Kits) were reduced by TOPK inhibitor treatment.
Results indicate that src (zeige SRC ELISA Kits)-family kinase (Src (zeige SRC ELISA Kits)) is a upstream kinase of T-LAK cell-originated protein kinase (TOPK).
Upregulation of proteasome subunit beta type 8 PSMB8 (zeige PSMB8 ELISA Kits) and PDZ binding kinase PBK was confirmed by real-time reverse transcription-PCR analysis.
MiR (zeige MLXIP ELISA Kits)-770-5p and PBK levels were inversely correlated in xenograft model mice.
TOPK knockdown did not alter radiation response in normal tissues, but significantly enhanced radiosensitivity in cancer cells.These findings have clinical relevance, as elevated TOPK protein expression was associated with poorer clinical outcomes in prostate cancer patients treated with radical radiotherapy. TOPK disruption may cause tumour-specific radiosensitisation in multiple different tumour types.
this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt (zeige AKT1 ELISA Kits) signaling pathway
T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (zeige DUSP1 ELISA Kits) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (zeige RNF19A ELISA Kits) signaling pathway.
The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.
Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.
This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
PDZ binding kinase
, T-LAK cell-originated protein kinase
, MAPKK-like protein kinase
, cancer/testis antigen 84
, lymphokine-activated killer T-cell-originated protein kinase
, serine/threonine protein kinase
, spermatogenesis-related protein kinase
, PDZ-binding kinase
, PBK, PDZ-binding kinase
, lymphokine-activated killer T-cell-originated protein kinase homolog