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PDS5B encodes a protein that interacts with the conserved protein complex termed cohesion. Zusätzlich bieten wir Ihnen PDS5B Antikörper (39) und und viele weitere Produktgruppen zu diesem Protein an.
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Pds5B forms an integral part of the cohesin ring by contacting all other cohesin subunits, a property that may reflect the complex role of Pds5 proteins in controlling cohesin-DNA interactions.
MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling.
The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B.
The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved.
The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL.
Pds5 stabilizes a transient, open state of cohesin to promote its release from chromosomes.
APRIN expression levels correlate with a better survival in ovarian cancer patients and that APRIN depletion sensitizes cells to the PARP inhibitor Olaparib in xenografted zebrafish.
Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability.
Here, the authors use proteomic profiling to identify APRIN (PDS5B), a cohesion-associated protein, as a BRCA2-associated protein.
Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma.
AS3 is a mediator of the proliferative arrest in the normal rat prostate in situ and that its expression is androgen-induced (AS3 protein)
The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC.
identified a functional missense mutation (R1292Q) in the PDS5B DNA-binding domain in a family with Cornelia de Lange syndrome, in which affected individuals also develop megacolon
Pard-3 and AS3 genes are mutationally inactivated in prostate cancer cells.
findings demonstrate that Her2+/+ mice, similar to Pds5b-/- mice, are embryonic lethal and confirm the necessity for Pds5b in embryonic development
reduced accumulation of Aurora B at the inner centromere region in cells lacking Pds5B impairs its error correction function, promoting chromosome mis-segregation and aneuploidy
demonstrates that overexpression of APRIN inhibits differentiation and proliferation and promotes apoptosis in P19 embryonal carcinoma cells.
A paper used gene targeting in mice to demonstrate the function of PDS5B in embryonic development.
APRIN, in addition to its Pds5 similarity, has the features and localization of a hormone-induced chromatin regulator.
While Pds5A(-/-) and Pds5B(-/-) mice die at birth, embryos harboring 3 mutant Pds5 alleles die between E11.5 and E12.5 most likely of heart failure, indicating that total Pds5 gene dosage is critical for normal development.
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene.
androgen induced inhibitor of proliferation
, androgen-induced proliferation inhibitor
, androgen-induced prostate proliferative shutoff-associated protein AS3
, androgen-induced shutoff 3
, sister chromatid cohesion protein PDS5 homolog B
, androgen-induced prostate proliferative shutoff associated protein
, PDS5, regulator of cohesion maintenance, homolog B
, androgen-induced prostate proliferative shutoff associated protein AS3
, androgen-induced proliferation inhibitor A
, sister chromatid cohesion protein PDS5 homolog B-A
, sister chromatid cohesion protein Pds5B