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Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death.
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We identified four new loci (PKNOX2, MYH13, PHF2 (zeige PHF1 Proteine), and GPC6 (zeige GPC6 Proteine)) associated with formal thought disorder in schizophrenia.
Using data from several genomewide case-control studies, we identified a strong and significant association signal with a novel gene, PKNOX2, on chromosome 11 with the composite phenotype in European-origin women
results indicated that Pknox2 misexpression affected mesenchymal condensation and early chondrogenic differentiation in the zeugopod skeletons of transgenic embryos
Prep2 functions to varying degrees in a broad array of tissues and developmental processes.
transcriptional regulation by PREP2 is modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001
PBX/knotted 1 homeobox 2
, homeobox protein PKNOX2-like
, PBX/knotted homeobox 2
, homeobox protein PKNOX2
, homeobox protein PREP-2
, homeodomain containing transcription factor PREP2
, homeobox protein Meis2-like