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C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008]..
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a PTIP (zeige PAXIP1 Antikörper)-PA1 subcomplex functions independently from the MLL3/MLL4 (zeige MLL4 Antikörper) complex to mediate transcription during CSR (zeige SCARA3 Antikörper)
subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8 (zeige RNF8 Antikörper)-dependent pathway and is required for cell survival in response to DNA damage.
PA1 (also known as C16orf (zeige PAXIP1 Antikörper)53 in human and 2900092E17R (zeige PAXIP1 Antikörper)ik in mouse) binds PTIP directly and req (zeige MLL4 Antikörper)uires PTIP for interac (zeige HIST3H3 Antikörper)tion with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex.
PA1 expression was observed in both nucleus (mainly)and cytoplasm from breast cancer tissue samples. PA1 nuclear expression was correlated with postmenopausal, smaller tumor size, negative Ki67 (zeige MKI67 Antikörper), positive AR and positive ERbeta (zeige ESR2 Antikörper). PA1 nuclear positive cases seemed to have a longer survival than negative ones for RFS. For those patients without lymphnode metastasis PA1 was found to be an independent prognostic factor for RFS.
PA1 is a new competitive decelerator of GR transactivation and can act at more than one molecularly defined step in a manner that depends upon the specific gene
PA1 (C16orf53) binds PTIP (zeige PAXIP1 Antikörper) directly and requires PTIP (zeige PAXIP1 Antikörper) for interaction with the MLL3- and MLL4 (zeige MLL2 Antikörper)-containing histone H3 (zeige HIST3H3 Antikörper) K4 methyltransferase complex.
C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007
PAXIP1-associated glutamate-rich protein 1
, PAXIP1-associated protein 1
, PTIP-associated protein 1
, PTIP-associated 1
, PTIP-associated 1 protein
, glutamate-rich coactivator associated with SRC1
, glutamate-rich coactivator interacting with SRC1/NCOA1