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Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. Zusätzlich bieten wir Ihnen OSBP2 Antikörper (42) und OSBP2 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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The authors uncovered a signalling pathway operating specifically in T-cell acute lymphoblastic leukemia cells in which ORP4L mediates G protein-coupled ligand-induced PLCbeta3 activation, resulting in an increase of mitochondrial respiration for cell survival.
High ORP4L expression is associated with cervical carcinoma.
ORP4L is crucial for macrophage survival and plays a role in the development of atherosclerosis.
ORP4 promotes the survival of rapidly proliferating cells.
Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation.
In preliminary results, significantly higher levels of OSBP2 and OSBPL-7 mRNA were seen in blood samples from cholangiocarcinoma patients than in healthy controls.
OSBP2 has a role in chronic myeloid leukemia
Thus the sterol-binding domain of ORP4 binds vimentin, cholesterol and oxysterols, and interacts with the filamentous vimentin network.
a possible role of OSBP2 gene in the pathogenesis of oxidative damage to the macula induced by oxysterols in age-related macular degeneration patients.
ORP4 is essential for the postmeiotic differentiation of germ cells
Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.
oxysterol-binding protein 2
, OSBP-related protein 4
, oxysterol binding protein-like 1
, oxysterol binding protein-related protein 4
, oxysterol-binding protein-related protein 4