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Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Zusätzlich bieten wir Ihnen OCSTAMP Antikörper (5) und viele weitere Produktgruppen zu diesem Protein an.
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Results indicte that oc-stamp may play an important role in macrophage polarization and inhibit the M1 pro-inflammatory state.
Restoring OC-STAMP in knockout cells by lentiviral transduction rescued fusion and resorption.
OC-STAMP is a regulatory molecule for FBGCs; and that they are functionally distinct from OCs, despite similarities in gene expression profile, podosome belt formation, and TRAP expression.
Fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP.
The osteoclast differentiation needs the coordinated expression of OC-STAMP with several molecules required for transcription, signaling transduction, and cell fusion.
OC-STAMP is a previously unknown, RANKL (zeige TNFSF11 Proteine)-induced, multipass transmembrane protein that promotes the formation of multinucleated osteoclasts. (Osteoclast stimulatory transmembrane protein)
Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).
transmembrane protein C20orf123
, transmembrane protein C20orf123 homolog