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ODC1 encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. Zusätzlich bieten wir Ihnen Ornithine Decarboxylase 1 Kits (50) und Ornithine Decarboxylase 1 Proteine (23) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ODC1 Primary Antibody für WB - ABIN518504
Ramot, Tiede, Bíró, Abu Bakar, Sugawara, Philpott, Harrison, Pietilä, Paus: Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. in PLoS ONE 2011
Human Monoclonal ODC1 Primary Antibody für IF, IP - ABIN518505
Selmi, de Saint-Jean, Jallas, Garin, Hogarty, Bénard, Puisieux, Marabelle, Valsesia-Wittmann: TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma. in Cancer letters 2014
molecular cloning of species-specific enzyme and its antizyme-mediated degradation
Extracellular polyamines induced proliferation and cancer cell migration by inducing ODC and SSAT (zeige SAT1 Antikörper) expression, and the Akt1 (zeige AKT1 Antikörper)-mediated pathway.
Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN).
Findings suggest that targeting ornithine decarboxylase 1 (ODC1) could be an attractive option for molecular therapy of hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)).
Binding of RS1 (zeige RS1 Antikörper)-Reg (zeige EXTL3 Antikörper) to ODC1 inhibits the enzymatic activity at low intracellular glucose, which is blunted at high intracellular glucose.
mechanistic study of the molecular interactions between antizyme inhibitor and its interacting proteins CCND1 (zeige CCND1 Antikörper) and ornithine decarboxylase
We earlier presented evidence for a physical interaction between ODC and SPR (zeige SPR Antikörper) and we showed that RNAi-mediated knockdown of SPR (zeige SPR Antikörper) expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma (zeige ARHGEF16 Antikörper) cell proliferation.
Bag-1 (zeige BAG1 Antikörper) indirectly affects cell survival through c-Myc (zeige MYC Antikörper) activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content.
High ODC expression is associated with Medulloblastoma.
Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN).
Data suggest that down-regulation of ODC (using siRNA or pharmacologic inhibitor) in bone marrow-derived mesenchymal stem cells results in reduced intracellular polyamines (putrescine, spermidine, and spermine) and enhanced osteogenesis.
Translation of ODC is therefore integral to cytoplasmic maturation, protecting metaphase II oocytes from reactive oxygen species-induced apoptosis.
these data support the hypothesis that TTP (zeige ZFP36 Antikörper) plays a role in the post-transcriptional regulation of the ODC mRNA transcript.
the Myc (zeige MYC Antikörper)-ODC axis plays a critical role in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 (zeige JAK2 Antikörper) V617F mutant
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase (zeige CTPS Antikörper) to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Androgens act via the AR to upregulate Odc1 in skeletal muscle myoblasts, and Odc1 promotes myoblast proliferation and delays differentiation.
the immunosuppression promoted by increased epidermal ODC is mediated by a reduction in cytokine levels, which suppresses dendritic cell migration and reduces immune cell infiltration to the site of hapten application
HuR (zeige ELAVL1 Antikörper) plays a causative role in ODC up-regulation during nonmelanoma skin cancer development by binding to and stabilizing the ODC transcript.
Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation
In B16-F1 cells HGF (zeige HGF Antikörper) increased AP-1 (zeige JUN Antikörper) activity and the mRNA expression of various AP-1 (zeige JUN Antikörper) subunits. HGF (zeige HGF Antikörper)-induced transcription of mouse ODC was largely due to triggering of AP-1 (zeige JUN Antikörper) pathway.
cell constituents required for mODC degradation are conserved between animals and fungi, and that both mammalian and fungal ODC are subject to proteasome-mediated proteolysis by ubiquitin-independent mechanisms
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
ornithine decarboxylase 1
, ornithine decarboxylase
, group IV decarboxylase
, Ornithine decarboxylase
, Ornitine decarboxylase
, ODC 1