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OC-3 is required for development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.
Data show that Onecut-2/Onecut-3 double knockout is a perinatal lethal.
hepatocyte nuclear factor-6/Onecut-1 (zeige ONECUT1 Proteine) controls the expression of its paralog Onecut-3 in developing mouse endoderm
In conclusion, CD44 (zeige CD44 Proteine) and Oct3/4 (zeige POU5F1 Proteine) overexpression may imply malignant transformation of pancreatic ducts and could help pathologists make a more accurate diagnosis and decision on clear surgical margins.
Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).
one cut domain family member 3
, one cut homeobox 3
, transcription factor ONECUT-3
, one cut domain, family member 3