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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell.
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Strikingly, OR51E2 was the most highly enriched OR transcript mapped to the human olfactome in lung-resident cells. In a heterologous expression system, OR51E2 trafficked readily to the cell surface and showed ligand selectivity and sensitivity to the short chain fatty acids (SCFAs) acetate and propionate.
OR51E2 is involved in the regulation of cell proliferation and migration in human primary melanoma and melanoma metastasis
Two genes, OR51E2 and SIM2 (zeige SIM2 Proteine), and two miRNAs, miR (zeige MLXIP Proteine)-200c and miR (zeige MLXIP Proteine)-200b, showed significant association with prostate cancer.
Plasma membrane preparations showed that OR51E2 protein is present at the melanocyte cell surface.
PSGR overexpression synergizes with loss of PTEN to accelerate prostate cancer development, and present a novel bigenic mouse model that mimics the human condition
Pyk2-NDRG1 axis is possibly involved in conveying the anti-proliferative effect of beta-ionone in prostate cancer cells.
Increased expression of prostate-specific G-protein-coupled receptor is associated with prostate intraepithelial neoplasia and prostate cancers
two functional promoters regulate the transcriptional expression of PSGR in human prostate tissues, and PSGR is a new target for IL-6 (zeige IL6 Proteine) transcriptional regulation
PSGR overexpression is associated with higher percentage of pathologic stage, pT3, and a higher level of preoperative serum PSA in Prostate Cancer
expression of PSGR and PSGR2 (zeige OR51E1 Proteine) relative to AMACR (zeige AMACR Proteine) in prostate cancer; AMACR (zeige AMACR Proteine) was the most overexpressed, but in some cases expression of AMACR (zeige AMACR Proteine) was not significantly elevated while PSGR and/or PSGR2 (zeige OR51E1 Proteine) were substantially elevated
Transgenic mice overexpressing PSGR in the prostate were reported to develop an acute inflammatory response followed by emergence of low grade prostatic intraepithelial neoplasia, whereas mice with compound PSGR overexpression and loss of PTEN exhibited accelerated formation of invasive prostate adenocarcinoma. (Review)
Olfr78 is involved in the regulation of hormone secretion from such cells, as evoked by nutritional compounds
in addition to its role in olfaction, Olfr78 acts as a hypoxia sensor in the breathing circuit by sensing lactate produced when oxygen levels decline
SCFAs produced by the gut (zeige GUSB Proteine) microbiota modulate blood pressure via Olfr78 and Gpr41 (zeige FFAR3 Proteine).
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
, olfactory receptor 51E2
, olfactory receptor OR11-16
, olfactory receptor, family 51, subfamily E, member 3 pseudogene
, olfactory receptor, family 52, subfamily A, member 2
, prostate specific G-protein coupled receptor
, prostate-specific G-protein coupled receptor
, G-protein coupled receptor RA1c
, olfactory receptor 78
, olfactory receptor MOR18-2
, cOR51E2P olfactory receptor family 51 subfamily E pseudogene