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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. Zusätzlich bieten wir Ihnen Olfactory Receptor, Family 51, Subfamily E, Member 2 Antikörper (38) und Olfactory Receptor, Family 51, Subfamily E, Member 2 Kits (15) und viele weitere Produktgruppen zu diesem Protein an.
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Strikingly, OR51E2 was the most highly enriched OR transcript mapped to the human olfactome in lung-resident cells. In a heterologous expression system, OR51E2 trafficked readily to the cell surface and showed ligand selectivity and sensitivity to the short chain fatty acids (SCFAs) acetate and propionate.
OR51E2 is involved in the regulation of cell proliferation and migration in human primary melanoma and melanoma metastasis
Two genes, OR51E2 and SIM2, and two miRNAs, miR-200c and miR-200b, showed significant association with prostate cancer.
Plasma membrane preparations showed that OR51E2 protein is present at the melanocyte cell surface.
PSGR overexpression synergizes with loss of PTEN to accelerate prostate cancer development, and present a novel bigenic mouse model that mimics the human condition
Pyk2-NDRG1 axis is possibly involved in conveying the anti-proliferative effect of beta-ionone in prostate cancer cells.
Increased expression of prostate-specific G-protein-coupled receptor is associated with prostate intraepithelial neoplasia and prostate cancers
two functional promoters regulate the transcriptional expression of PSGR in human prostate tissues, and PSGR is a new target for IL-6 transcriptional regulation
PSGR overexpression is associated with higher percentage of pathologic stage, pT3, and a higher level of preoperative serum PSA in Prostate Cancer
expression of PSGR and PSGR2 relative to AMACR in prostate cancer; AMACR was the most overexpressed, but in some cases expression of AMACR was not significantly elevated while PSGR and/or PSGR2 were substantially elevated
We identified androstenone derivatives as ligands for the recombinant receptor PSGR
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
, olfactory receptor 51E2
, olfactory receptor OR11-16
, olfactory receptor, family 51, subfamily E, member 3 pseudogene
, olfactory receptor, family 52, subfamily A, member 2
, prostate specific G-protein coupled receptor
, prostate-specific G-protein coupled receptor
, cOR51E2P olfactory receptor family 51 subfamily E pseudogene