Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 Proteine (NUDT1)

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Zusätzlich bieten wir Ihnen NUDT1 Antikörper (66) und NUDT1 Kits (10) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NUDT1 4521 P36639
NUDT1 17766 P53368
NUDT1 117260 P53369
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top NUDT1 Proteine auf antikoerper-online.de

Showing 8 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$327.80
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$331.20
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,286.17
Details
Escherichia coli (E. coli) Human His tag   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$3,655.38
Details
Human Unkonjugiert   1 mg Anmelden zum Anzeigen 6 Days
$4,125.00
Details

NUDT1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) Interaktionspartnern

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) Interaktionspartner

  1. overall our cell viability data indicates that targeting MTH1 will likely not be an across-the-board effective non-small cell lung cancer therapeutic strategy; rather it induces non-cytotoxic DNA damage that could promote cancer heterogeneity and evolution.

  2. MTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells.

  3. PRDX1 (zeige PRDX1 Proteine) and MTH1 cooperate to prevent accumulation of oxidized guanine in the genome

  4. Results provide evidence that MTH1 is not essential for cancer cell survival.

  5. CDT1 (zeige CDT1 Proteine), MCM7 (zeige MCM7 Proteine), and NUDT1 were shown to be up-regulated in hepatocellular carcinoma tissues and provide a more accurate diagnosis than alpha-fetal protein alone.

  6. Our results reveal a novel antitumor mechanism of (S)-crizotinib in NSCLC which involves activation of ROS (zeige ROS1 Proteine)-dependent ER stress apoptotic pathway and is independent of MTH1 inhibition

  7. this study showed that MTH1 protein expression was closely related to factors associated with a high malignant potential and poor patient survival

  8. method for predicting individual residue contributions to enzyme specificity and binding-site energies, and its application to MTH1.

  9. Data indicate the specificity of the enzyme 8-oxo-dGTPase MTH1 toward the substrate 8-oxo-dGTP.

  10. We demonstrate that in order to kill cancer cells MTH1 inhibitors must also introduce oxidized nucleotides into DNA. Furthermore, we describe TH1579 as a best-in-class MTH1 inhibitor, which we expect to be useful in order to further validate the MTH1 inhibitor concept.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) Interaktionspartner

  1. Increased cytotoxicity following MTH1 knockout or treatment with MTH1 inhibitor suggests the oxidation of precursor nucleotides.

  2. The crystal structures of mouse MTH1 in complex with inhibitor TH588 and dog MTH1 elucidate the structural and sequence basis for the observed difference in their affinities for TH588. Amino acid residue 116 in MTH1 is an important determinant of TH588 affinity. The structure of mouse MTH1 in complex with the substrate 8-oxo-dGTP is presented.

  3. These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.

  4. MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP.

  5. MTH1 efficiently suppresses the accumulation of 8-oxoG in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity.

NUDT1 Protein Überblick

Protein Überblick

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Genbezeichner und Symbole assoziert mit NUDT1

  • 7,8-dihydro-8-oxoguanine triphosphatase (mth1)
  • 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498)
  • nudix hydrolase 1 (nudt1)
  • 7,8-dihydro-8-oxoguanine triphosphatase (8odp)
  • nudix hydrolase 1 (NUDT1)
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1)
  • nudix hydrolase 1 (Nudt1)
  • Mth1 Protein
  • mutT Protein
  • nudT1 Protein

Bezeichner auf Proteinebene für NUDT1

7,8-dihydro-8-oxoguanine triphosphatase , 2-hydroxy-dATP diphosphatase , 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase , 8-oxo-7,8-dihydroguanosine triphosphatase , 8-oxo-dGTPase , mutT human homolog 1 , nucleoside diphosphate-linked moiety X motif 1 , nucleoside diphosphate-linked moiety X-type motif 1 , nudix motif 1 , 8-oxo-7,8-dihydro-2'-dGTPase , mutT human homolog (8-oxo-dGTPase) , nudix-type motif 1

GENE ID SPEZIES
8791327 Azospirillum sp. B510
10901982 Trichinella spiralis
100195837 Salmo salar
100305248 Oncorhynchus mykiss
4521 Homo sapiens
17766 Mus musculus
117260 Rattus norvegicus
Ausgewählte Anbieter für NUDT1 Proteine (NUDT1)
Haben Sie etwas anderes gesucht?