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Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane.
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The Caenorhabditis elegans lamin, LMN-1, is required for nuclear migration and interacts with the nucleoplasmic domain of the SUN protein UNC-84.
In LMN-1 Y59C (a point mutation)-expressing worms, there is abnormal retention at the nuclear envelope of a gene array bearing a muscle-specific promoter. This correlates with altered expression of a number of muscle-specific genes.
A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in Caenorhabditis elegans.
documented that the single nuclear lamin of C. elegans assembles in low ionic strength Tris-HCl buffer into stable 10-nm filaments that exhibit a normal intermediate filament morphology
Both lamin Dm0 and C. elegans Ce-lamin bind directly to histone H2A in vitro and this binding requires a nuclear localization signal
Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans.