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NFIA encodes a member of the NF1 (nuclear factor 1) family of transcription factors.
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The consistent overlap in clinical presentation provides further evidence of the critical role of NFIA haploinsufficiency in the development of the 1p32-p31 microdeletion syndrome phenotype.
Data define a previously unknown nuclear factor I-A-nuclear factor-kappaB feed-forward regulation that may contribute to glioblastoma cell survival.
Altogether, these results demonstrated that miR (zeige MLXIP ELISA Kits)-370 suppressed hepatitis B virus gene expression and replication through repressing NFIA expression, which stimulates hepatitis B virus replication via direct regulation on hepatitis B virus Enhancer I activities.
We verified that NFIA binds to the IGFBP2 (zeige IGFBP2 ELISA Kits) promoter and transcriptionally enhances IGFBP2 (zeige IGFBP2 ELISA Kits) expression levels. We identified that NFIA-mediated IGFBP2 (zeige IGFBP2 ELISA Kits) signaling pathways are involved in miR (zeige MLXIP ELISA Kits)-302b-induced glioma cell death.
miR (zeige MLXIP ELISA Kits)-191 was upregulated in patients with middle- and late-stage NSCLC, and in NSCLC cell lines, under mild hypoxic conditions. miR (zeige MLXIP ELISA Kits)-191 promoted the proliferation and migration of NSCLC under chronic hypoxic conditions, and this promotion may be associated with its targeting of NFIA.
Dihydrocapsaicin can significantly decrease proinflammatory cytokines through enhancing NFIA and inhibiting NF-kappaB (zeige NFKB1 ELISA Kits) expression
These results demonstrated that RP5833A20.1 inhibited tumor cell proliferation, induced apoptosis and inhibited cellcycle progression by suppressing the expression of NFIA in U251 cells.
NFI-A is involved in the miR (zeige MLXIP ELISA Kits)-21-induced expression of IL-10 (zeige IL10 ELISA Kits) in B cells in nasopharyngeal carcinoma; Il-10 (zeige IL10 ELISA Kits) is capable of suppressing CD8 (zeige CD8A ELISA Kits)+ T-cell activities.
microRNA-136 targeted and degraded NFIA, which induced the release of microRNA-223, promoting CD11b (zeige ITGAM ELISA Kits) expression. Direct base pairing occurs between miR (zeige MLXIP ELISA Kits)-136 and the 3' UTR (zeige UTS2R ELISA Kits) of NFIA mRNA.
this family also carried a microdeletion affecting solely the NFIA gene, this study substantiates the importance of this gene in craniofacial development.
NFIA expression regulates glioma tumorigenesis and glia-specific enhancers enhancers contribute to glioma formation.
NFIA activates the cell-type-specific enhancers and facilitates the binding of PPARgamma (zeige PPARG ELISA Kits) to control the brown fat gene program.
Astrocyte induction by Zbtb20 is suppressed by knockdown of NFIA.
NFI-A disrupts myeloid cell differentiation and maturation in septic mice
NFIA and NFIB are endogenously expressed in gradients with high caudo-medial to low rostro-lateral expression ... this expression pattern deviates from that of PAX6, suggesting that PAX6 does not drive Nfi expression
RP5-833A20.1/miR (zeige MLXIP ELISA Kits)-382-5p/NFIA pathway was essential to the regulation of cholesterol homeostasis and inflammatory reactions.
Nfia cooperates with sonic hedgehog (zeige SHH ELISA Kits) signaling to initiate medulloblastoma.
Our data thus suggest that NFI nucleosomal interaction may contribute to the partitioning of distinct chromatin domains and to epigenetic gene expression regulation
As maturing cerebellar granule neurons become more hyperpolarized, NFATc4 binding declines leading to onset of NFI temporal binding and the NFI switch program
This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene.
nuclear factor I/A
, CCAAT-box-binding transcription factor
, TGGCA-binding protein
, nuclear factor 1 A-type
, nuclear factor 1/A
, nuclear factor I-A