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Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Zusätzlich bieten wir Ihnen NFE2 Antikörper (41) und viele weitere Produktgruppen zu diesem Protein an.
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NF-E2 silencing in hematopoietic stem and progenitor cells (HSPCs) did not affect their myeloid and B cell differentiation in vivo, it almost abrogated T cell production in primary hosts, as confirmed by in vitro studies. This effect is at least partly due to Notch1 (zeige NOTCH1 Proteine) downregulation in NF-E2-silenced HSPCs.
results suggest that p45 NF-E2 negatively regulates differentiation and apoptosis activation of human syncytiotrophoblast by modulating GCM1 (zeige GCM1 Proteine) acetylation and sumoylation.
NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR
under the obese condition, activation of the hepatic NFE2/miR (zeige MLXIP Proteine)-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A (zeige FAM3A Proteine)-ATP-Akt (zeige AKT1 Proteine) signaling pathway.
Our data presented herein support the hypothesis that cytoplasmically located NF-E2 may have a function in the elimination of internal organelles. The mild autophagy defect observed in our mice may be due to the requirement for additional proteins in the formation of larger complexes to exert this function.
assessment of NF-E2 and NGFR (zeige NGFR Proteine) expression may provide additional support in reaching a correct diagnosis in discriminating polycythemia vera (zeige IGF2BP3 Proteine) from prefibrotic/fibrotic primary myelofibrosis and essential thrombocythemia
The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells
the RUNX1 (zeige RUNX1 Proteine) target NF-E2 is part of the molecular network by which RUNX1 (zeige RUNX1 Proteine) regulates platelet biogenesis and function in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia
A functional link among the erythroid transcription factors GATA-1 (zeige GATA1 Proteine)/NF-E2, miR (zeige MLXIP Proteine)-199b-5p in erythropoiesis.
NF-E2 immunohistochemistry and analysis of the proportion of nuclear positive erythroblasts of all erythroid precursor cells can help to distinguish between ET and PMF (zeige PRB1 Proteine) even in early stages of the diseases.
Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1 (zeige RUNX1 Proteine), FLI1 (zeige FLI1 Proteine) or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.
Under the obese condition, activation of the hepatic NFE2/miR (zeige MLXIP Proteine)-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A (zeige FAM3A Proteine)-ATP-Akt (zeige AKT1 Proteine) signaling pathway.
results suggest that Nrf2 (zeige NFE2L2 Proteine) deficiency induced by HFD promoted hepatic fatty acid metabolism disorder by altering 18-carbon and 22-carbon fatty acid composition
A novel murine model may excellently describe the deleterious impact of sustained chronic NF-E2 overexpression during uncontrolled chronic inflammation upon the hematopoietic system--the development of clonal myeloproliferation.
Although none of the parameters measured were different between the NF-E2 deficient and control mice, an increase in calcium (21%) and an increase in the mineral/matrix ratio (32%) was observed in GATA-1 (zeige GATA1 Proteine) deficient mice.
By activating genes in megakaryocytes that mediate platelet production and function, NF-E2 p45 determines the quantity and quality of platelets.
maintaining expression of intestinal epithelial cell prohibitin (zeige PHB Proteine) reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 (zeige HMOX1 Proteine) and NQO-1 (zeige NQO1 Proteine) via a mechanism independent of Nfe2
These findings demonstrate that a combination of p45NF-E2, Maf (zeige MAF Proteine) G, and Maf (zeige MAF Proteine) K is a key determinant of both megakaryopoiesis and thrombopoiesis.
Loss of p45 NF-E2 leads to a 2-fold increase in serum erythropoietin (zeige EPO Proteine) & increased splenic erythropoiesis. Erythroid cells were arrested at the G(1) stage of cell cycle.
Nfe2 modulates JunD (zeige JUND Proteine) binding to the Gcm1 (zeige GCM1 Proteine) promoter via acetylation
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
leucine zipper protein NF-E2
, nuclear factor, erythroid derived 2
, nuclear factor, erythroid-derived 2 45 kDa subunit
, p45 NF-E2
, transcription factor NF-E2 45 kDa subunit
, nuclear factor (erythroid-derived 2), 45kD
, nuclear factor (erythroid-derived 2), 45kDa
, nuclear factor, erythroid derived 2, 45 kDa