Nicotinate phosphoribosyltransferase Domain Containing 1 Proteine (NAPRT1)

Nicotinic acid (NA\; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT\; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen NAPRT1 Antikörper (44) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NAPRT1 93100 Q6XQN6
Maus NAPRT1 NAPRT1 223646 Q8CC86
NAPRT1 315085 Q6XQN1
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Top NAPRT1 Proteine auf antikoerper-online.de

Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen Verfügbar
$284.90
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Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 5 bis 8 Tage
$656.81
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,536.50
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Escherichia coli (E. coli) Bacillus subtilis Unkonjugiert   50 μg Anmelden zum Anzeigen 5 bis 8 Tage
$656.81
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NAPRT1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Rat (Rattus)

Weitere Proteine zu Nicotinate phosphoribosyltransferase Domain Containing 1 (NAPRT1) Interaktionspartnern

Human Nicotinate phosphoribosyltransferase Domain Containing 1 (NAPRT1) Interaktionspartner

  1. No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma

  2. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases

  3. High NAPRTase expression is associated with neoplasms.

  4. Tumor-specific promoter hypermethylation of NAPRT1 inactivates one of two NAD salvage pathways, resulting in synthetic lethality with the coadministration of a NAMPT inhibitor.

  5. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner

  6. NAPRT expression was varied in lymphomas with 30-50% low expression except for Hodgkin's lymphoma where 85% displayed low expression

  7. NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD

NAPRT1 Protein Überblick

Protein Überblick

Nicotinic acid (NA\; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT\; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).

Genbezeichner und Symbole assoziert mit NAPRT1

  • nicotinate phosphoribosyltransferase (NAPRT)
  • nicotinate phosphoribosyltransferase (Naprt)
  • nicotinate phosphoribosyltransferase (naprt)
  • 9130210N20Rik Protein
  • PP3856 Protein
  • zgc:77870 Protein

Bezeichner auf Proteinebene für NAPRT1

FHA-HIT-interacting protein , NAPRTase , nicotinate phosphoribosyltransferase , nicotinate phosphoribosyltransferase domain-containing protein 1 , nicotinic acid phosphoribosyltransferase , nicotinate phosphoribosyltransferase-like protein

GENE ID SPEZIES
93100 Homo sapiens
223646 Mus musculus
315085 Rattus norvegicus
399559 Bos taurus
393864 Danio rerio
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