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NAMPT encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. Zusätzlich bieten wir Ihnen NAMPT Antikörper (373) und NAMPT Kits (138) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 60 products:
Human NAMPT Protein expressed in Escherichia coli (E. coli) - ABIN413884
Šenolt, Kuklová, Cerezo, Hulejová, Filková, Bošanská, Pecha, Pavelka, Haluzík, Vencovský: Adipokine profile is modulated in subcutaneous adipose tissue by TNF? inhibitors in patients with rheumatoid arthritis. in Annals of the rheumatic diseases 2011
Show all 2 Pubmed References
Human NAMPT Protein expressed in Escherichia coli (E. coli) - ABIN1344091
Yonezawa, Haga, Kobayashi, Takahashi, Obara: Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway. in FEBS letters 2006
Show all 2 Pubmed References
Mouse (Murine) NAMPT Protein expressed in Escherichia coli (E. coli) - ABIN413887
Kanda, Hau, Tada, Tatsuta, Sato, Watanabe: Visfatin enhances CXCL8, CXCL10, and CCL20 production in human keratinocytes. in Endocrinology 2011
Rat (Rattus) NAMPT Protein expressed in HEK-293 Cells - ABIN1344283
Spinnler, Gorski, Stolz, Schuster, Garten, Beck-Sickinger, Engelse, de Koning, Körner, Kiess, Maedler: The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. in PLoS ONE 2013
Mouse (Murine) NAMPT Protein expressed in Escherichia coli (E. coli) - ABIN1344090
Brown, Onyango, Ramanjaneya, Conner, Patel, Dunmore, Randeva: Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells. in Journal of molecular endocrinology 2010
Observed NAMPT overexpression in patients with Graves' disease with and without (GO) orbitopathy and its relatively low levels in thyroids of patients with Graves' disease (GD)without eye changes do not confirm causal relationship between NAMPT level and orbitopathy, but this needs further investigation.
Visfatin seems to be a good marker of endometrial cancer progress. High visfatin serum level predicts poor prognosis in endometrial cancer patients.
NAMPT expression downregulation by mir (zeige MLXIP Proteine)-206 reduces cell survival of breast cancer cells
No correlation between IDH1 (zeige IDH1 Proteine)/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma
NAMPT as a key player in BRAFi resistance and melanoma cell plasticity
This study has shown Resistin (zeige RETN Proteine), and Visfatin synergistically increased gastric cancer cell proliferation and enhanced the telomerase gene expression, showing that these two hormones in gastric cancer tissue could cooperatively accelerate cancer cell growth
Serum Nampt was increased in diabetic nephropathy patients.
NAMPT is highly upregulated in human gingival fibroblasts, while its enzymatic activity acts as a crucial mediator of periodontal inflammation and alveolar bone destruction via regulation of catabolic factors COX-2, MMP1 (zeige MMP1 Proteine), and MMP3 (zeige MMP3 Proteine) levels.
Results show that adiponectin, resistin (zeige RETN Proteine) and visfatin are present in osteophytes but have no direct influence on osteophyte development. Although these adipokines induce several inflammatory mediators, they do not affect osteoblast- or chondrocyte-related mechanisms of osteophyte development.
Cells were treated with 10 nM FK866, an NAMPT inhibitor, resulting in a decrease in the cellular NAD level.
our study demonstrated that PBEF ameliorates ischemia-induced neuronal death through inhibiting caspase (zeige CASP3 Proteine)-dependent and independent apoptotic signaling pathways and suppressing mitochondrial damage and dysfunction. Our study provides novel insights into the mechanisms underlying the neuroprotective effect of PBEF, and helps to identify potential targets for ischemic stroke therapy.
the NAMPT-mediated NAD(+) biosynthesis pathway is a potential therapeutic target for degenerative motor neuron diseases.
observations demonstrate that NAMPT knockdown exerted antiatherogenic effects by promoting cholesterol efflux and macrophage RCT (zeige FOXE3 Proteine) through the PPARalpha (zeige PPARA Proteine)- LXRalpha (zeige NR1H3 Proteine)- ABCA1 (zeige ABCA1 Proteine)/G1pathway in vitro and in vivo
Study found that primary mouse embryonic fibroblast (MEF) cells undergo progressive decline of NAMPT and NAD(+) contents during serial passaging before becoming senescent; further found that constitutive Nampt over-expression increases SIRT1 (zeige SIRT1 Proteine) activity, increases the expression of antioxidant genes, superoxide dismutase 2 (zeige SOD2 Proteine) and catalase (zeige CAT Proteine) and promotes resistance against oxidative stress.
NAMPT-mediated NAD(+) biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin (zeige INS Proteine) sensitivity in mice.
NAMPT-mediated NAD(+) biosynthesis is essential for vision in mice.
NAMPT is involved in key basic cellular functions.
role of Nampt in regulating osteoblast differentiation in primary mouse bone marrow-derived mesenchymal stem cells (BM-MSCs); Nampt expression was progressively elevated during BM-MSCs osteogenic differentiation
The results suggest that NCOA6 (zeige NCOA6 Proteine) stimulates insulin (zeige INS Proteine) secretion, at least partially, by modulating Nampt expression in pancreatic beta-cells.
the protein expression levels of TIMP-2 (zeige TIMP2 Proteine) and PBEF in cloned placentae, were examined.
In a wild boar x Meishan F2 family nicotinamide phosphoribosyltransferase nicotinamide phosphoribosyltransferase SNP 669T>C was associated with muscling, fat deposition, growth and fattening, meat quality and other traits.
cloning and characterization of porcine visfatin and its three alternate splicing variants is reported; sequence analysis indicated that variant 1 is the predominant form among species.
The porcine visfatin gene cannot be considered as a marker of fat accumulation since the highest visfatin expression levels were associated with the leaner (zeige CACNA1A Proteine) animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (zeige IL8 Proteine) and PTGS2 (zeige PTGS2 Proteine), and decreased the expression of SOD2 (zeige SOD2 Proteine), GPX3 (zeige GPX3 Proteine), DAB2 (zeige DAB2 Proteine), and NR3C1 (zeige NR3C1 Proteine). TNF (zeige TNF Proteine) and IL6 (zeige IL6 Proteine) levels were also decreased while those of NAMPT were unaffected.
the presence of 35bp-insertion in visfatin gene may influence the birth weight and bodyweight in 6-month-old cows.
These results indicate that mammary epithelial cells express the visfatin protein and secrete them into the milk.
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10.
, pre-B cell-enhancing factor
, pre-B-cell colony enhancing factor 1
, pre-B-cell colony-enhancing factor 1
, pre-B-cell colony-enhancing factor 1 homolog
, Nicotinamide phosphoribosyltransferase
, nicotinamide phosphoribosyltransferase
, pre-B-cell colony-enhancing factor-like protein