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NPTX2 encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein.
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Human Polyclonal NPTX2 Primary Antibody für IHC, ELISA - ABIN1002932
Moran, Hickey, Michael, Derkacs, Christian, Kalaitzakis, Pearce, Graeber: Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. in Acta neuropathologica 2008
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Dog (Canine) Polyclonal NPTX2 Primary Antibody für WB - ABIN611028
Biederer, Südhof: Mints as adaptors. Direct binding to neurexins and recruitment of munc18. in The Journal of biological chemistry 2001
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Bat Polyclonal NPTX2 Primary Antibody für WB - ABIN611029
Wong, Setou, Teng, Takei, Hirokawa: Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Neuronal pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer's disease spectrum. This research may advance the current understanding of Alzheimer's disease etiopathogenesis, while expanding early diagnostic techniques through the use of novel pro-inflammatory biomarkers, such as NPTX2.
NPTX2 in human cerebrospinal fluid is reduced in subjects with Alzheimer's disease and shows robust correlations with cognitive performance and hippocampal volume.
PTX2 (zeige APCS Antikörper) was identified PTX2 (zeige APCS Antikörper) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI (zeige MSR1 Antikörper)-mediated uptake by macrophages.
Decreased NPTX2 expression in rectal adenocarcinomas is associated with improved response to neoadjuvant chemoradiation and improved prognosis.
we show that NPTX2 is a marker of poor prognosis for neuroblastoma (zeige ARHGEF16 Antikörper) patients.
NPTX2 is overexpressed specifically in ccRCC primary tumors.
NPTX2 repressed NF-kappaB (zeige NFKB1 Antikörper) activity by inhibiting AKT (zeige AKT1 Antikörper) through a p53 (zeige TP53 Antikörper)-PTEN-dependent pathway, thus explaining the hypermethylation and downregulation of NPTX2 in NF-kappaB (zeige NFKB1 Antikörper)-activated high-risk glioblastomas.
Promoter methylation of NPTX2 is associated with glioblastoma.
Detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas
The visual cortex of NARP-deficient transgenic mice is hyperexcitable and unable to express ocular dominance, although many aspects of visual function are unimpaired.
PTX2 (zeige PITX2 Antikörper) was identified PTX2 (zeige PITX2 Antikörper) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI (zeige MSR1 Antikörper)-mediated uptake by macrophages.
Early postnatal NPTX2(-/-)/NPTXR (zeige NPTXR Antikörper)(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials
Nptx2 contributes to the development of L-DOPA-induced dyskinesia.
These findings suggest that Narp, and perhaps other neuronal pentraxins, also regulate inflammation in the nervous system.
Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.
the results of this study indicated that Narp released from mPFC neurons plays a key role in mediating synaptic changes underlying instrumental reinforcer devaluation.
Narp prominently accumulated at excitatory synapses on parvalbumin (zeige PVALB Antikörper)-expressing interneurons, propose that Narp recruits AMPARs at excitatory synapses onto interneurons to rebalance network excitation/inhibition dynamics following increased circuit activity
data indicate that the loss of NP1 (zeige NPX1 Antikörper)/2 disrupts several aspects of retinogeniculate development including the initial establishment of AMPAR transmission and the subsequent elimination of inappropriate circuit connections
Neuronal pentraxin 1 (zeige NPX1 Antikörper) and 2 are necessary for early synaptic refinements in mammalian retina and dorsal lateral geniculate nucleus. May exert their effects through mechanisms paralleling known role of short pentraxins outside the CNS. (Pentraxin 1 (zeige CRP Antikörper) and 2)
these findings provide compelling evidence that Narp is secreted from vasopressin (zeige AVP Antikörper) neurons in an activity-dependent fashion
characterized the expression of nptx2a in larvae and adults and established a transcription activator-like effector nuclease (zeige DCLRE1C Antikörper) (TALEN)-mediated nptx2a mutant (nptx2a(-/-)) to study the role of Nptx2a in regulating structural synaptic plasticity and behavior
This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.
, neuronal activity-regulated pentaxin
, neuronal pentraxin-2
, neuro activity regulated petaxin
, neuronal pentraxin II
, neuronal activity-regulated pentraxin
, neuronal pentraxin 2
, acrosomal pentaxin-like protein p50
, neuronal pentraxin 2a