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NEUROD2 encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Zusätzlich bieten wir Ihnen Neurogenic Differentiation 2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Dog (Canine) Polyclonal NEUROD2 Primary Antibody für ELISA, WB - ABIN4338736
Zill, Büttner, Eisenmenger, Bondy: A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior. in Molecular psychiatry 2006
Using genome-wide, mRNA-based microarray analysis, study found that NeuroD2 is actually one of hundreds of genes whose mRNA levels are suppressed by synaptic activity, in a manner dependent upon N-methyl d-aspartate receptor (zeige GRIN1 Antikörper) (NMDAR (zeige GRIN1 Antikörper)) activation. Study confirmed this observation both in vitro and in vivo and provide evidence that this happens at the level of transcription and not mRNA stability.
Genome-wide target gene analysis of the neurogenic transcription factor NEUROD2 has uncovered a novel gene expression mechanism by which differentiating cortical excitatory neurons fine-tune the extent of store-operated calcium entry. In vivo analysis identified Stim1 (stromal interaction molecule 1 (zeige STIM1 Antikörper)) as a primary target of NEUROD2.
Our results reveal an important function for NeuroD2 in balancing synaptic neurotransmission and intrinsic excitability and offer insight into how these processes are coordinated during cortical development.
Our analysis of in vivo NEUROD2 target genes offers mechanistic insight into signaling pathways that regulate neuronal migration and axon guidance and identifies genes that are likely to be required for proper cortical development.
we have identified basic helix-loop-helix (bHLH) transcription factors Neurod2 and Neurod6 (zeige NEUROD6 Antikörper) as key regulators of fasciculation and targeted axogenesis in the mouse neocortex
Over-expression of neuroD2 (ND2 (zeige MT-ND2 Antikörper)) leads to morphological differentiation of neuroblastoma (zeige ARHGEF16 Antikörper) cells and increased expression of synaptic proteins.
These experiments identify NeuroD2 as a key transcription factor that regulates the structural and functional differentiation of mossy fiber synapses in vivo.
NeuroD2 is expressed in amacrine, ganglion, and bipolar cells of the mature mouse retina.
Our study supports a model wherein NeuroD2 induces transcription of neuronal genes and Zfhx1a (zeige ZEB1 Antikörper), which in turn de-represses neuronal differentiation by down-regulating REST, and suppresses competing myogenic fate.
expression is probably regulated by immediate-early (zeige JUN Antikörper) transcription factors and is thought to be involved in long-lasting neuronal activation.
Our findings suggest that the NEUROD2 gene could play a role in the pathophysiology of neurocognitive dysfunctions as well as in the change of cognitive symptoms under antipsychotic treatment in schizophrenia and schizoaffective disorder.
Downregulation of NEUROD2 is associated with neurodevelopmental defects in trisomies 18.
The results of this study did not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence.
Lower neuroD2 mRNA levels was found in opiate-dependent individuals in the cortex and hippocampus.
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.
neurogenic differentiation 2
, neurogenic differentiation factor 2
, neuroD-related factor
, class A basic helix-loop-helix protein 1
, neurogenic basic-helix-loop-helix protein
, brain bHLH protein KW8