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NRN1 is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. Zusätzlich bieten wir Ihnen Neuritin 1 Antikörper (63) und Neuritin 1 Proteine (18) und viele weitere Produktgruppen zu diesem Protein an.
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NRN1 is expressed more extensively in melanoma than in normal melanocytes and healthy tissue. Secreted NRN1 seems to play a role also in earlier phases of melanoma development as we can discover NRN1 over-expression to be associated to primary melanoma
results suggest that DTNBP1 (zeige DTNBP1 ELISA Kits) and NRN1 genes show a joint effect on the risk for schizophrenia spectrum disorders. Although the precise mechanism underlying this effect is unclear, the fact that these genes have been involved in synaptic maturation, connectivity and glutamate (zeige GRIN1 ELISA Kits) signalling suggests that our findings could be of value as a link to the schizophrenia aetiology.
NRN1 is associated with depressive symptoms and executive function in a non-clinical sample. Our results also suggest that the role of NRN1 seems to be modulated by BDNF (zeige BDNF ELISA Kits).
On analysis of the expression of NRN1 in SMA (zeige SMN1 ELISA Kits) patients for the first time, NRN1 could be a potential modifier gene
Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
(i) NRN1 variability is a shared risk factor for both schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), (ii) NRN1 may have a selective impact on age at onset and intelligence in SSD.
Data indicate that neuritin not only plays an important role in the nervous system but also has an effect on the migration, senescence, proliferation, and viability of stem cells
Neuritin is reduced in the brains of Alzheimer's disease (AD) patients.
MiR (zeige MLXIP ELISA Kits)-204 promotes apoptosis in oxidative stress-induced (zeige SQSTM1 ELISA Kits) rat Schwann cells by suppressing neuritin expression
we found neuritin is overexpressed in astrocytoma, which may be an important factor in tumorigenesis and progression of astrocytoma
Following cerebral ischemia there is an increase in cpg15 expression in hippocampal astrocytes.
Neuritin prevents extremely low-frequency electromagnetic fields-exposure-induced memory deficit by increasing the hippocampal spine density.
Neuritin can normalize neural deficits of Alzheimer's disease.
Neuritin restors the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neuron cultures from a Alzheimer disease mouse model.
Activity-dependent development of the visual system requires synapse stabilization and maturation via CPG15.
CPG15 acts to stabilize active synapses on dendritic spines, resulting in selective spine and arbor stabilization and synaptic maturation, and that synapse stabilization mediated by CPG15 is critical for efficient learning
Data show that SMN (zeige STMN1 ELISA Kits) and HuD form a complex in spinal motor axons, and that both interact with cpg15 mRNA in neurons.
Cpg15 is an immediate-early (zeige JUN ELISA Kits) gene induced by Ca(2 (zeige CA2 ELISA Kits)+) influx through NMDA receptors and L-type voltage-sensitive calcium channels. It requires convergent activation of the CaM kinase (zeige CAMK2 ELISA Kits) and MAP kinase (zeige MAPK1 ELISA Kits) pathways.
Regulation of cpg15 expression during single whisker experience in the barrel cortex of adult mice.
This gene is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. In vitro assays demonstrated that this protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis.
, neuritin 1
, candidate plasticity gene 15 protein
, candidate plasticity-related gene 15