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NRXN3 encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules.
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NRXN2 may play a part in early cortical synaptogenesis, but NRXNs could have diverse roles in development including axon guidance, and intercellular communication between proliferating cells and/or migrating neurons.
The rare variants in NRXN3 were significantly associated with smoking status.
This study confirmed the genetic heterogeneity of cluster headache, suggesting that a novel rearrangement involving NRXN3 gene might be related to cluster headache in a subset of cases
The study showed that markers rs2217887 (NRXN3) showed weak associations.
a positive association between Neurexin 3 and controls in the Han Chinese population, and genetic evidence to support the susceptibility of DEACMP
Neurexin 3-alpha (NRXN3) is a synaptic cell-cell adhesion molecule (zeige PCDHB16 ELISA Kits) involved in maintenance of neural connections (such as the maintenance of smoking behavior).
By age 7, common variations in FTO (zeige FTO ELISA Kits), TMEM18 and NRXN3 influence the vulnerability to metabolic complications of sleep deprivation.
Our findings suggested that NRXN3 might represent a major susceptibility gene for schizophrenia
the study finds preliminary evidence for the association of NRXN3 with Borderline Personality Disorder phenotypes. The strongest association with positive screening for BPD was found for SNP rs10083466.
FoxQ1 (zeige FOXQ1 ELISA Kits) promotes glioma cell proliferation and migration by down-regulation of NRXN3 expression.
In the present study, we report that Nrxn3beta is processed by the metalloproteases ADAM10 (zeige ADAM10 ELISA Kits), ADAM17 (zeige ADAM17 ELISA Kits), and by the intramembrane-cleaving protease gamma-secretase, producing secreted neurexin3beta (sNrxn3beta) and a single intracellular domain (Nrxn3beta-ICD). Thea (zeige ACOT11 ELISA Kits) authors show that sNrxn3beta produced by the cells of the dentate gyrus increases the spine density of newborn neurons.
Nrxn3 is responsible for the neuroligins (NLs)-induced assembly of GABAergic synapses in co-culture. Importantly, lentivirus-based expression of Nrxn3 containing exon 20 restores the reduced NLs-induced GABAergic contacts in the SLM2 E/E co-culture.
After pan-neurexin (zeige NRXN1 ELISA Kits) deletions, we observed in these synapses severe but dramatically different synaptic phenotypes that ranged from major impairments in their distribution and function (climbing-fiber synapses) to large decreases in synapse numbers (parvalbumin (zeige PVALB ELISA Kits)-positive synapses) and severe alterations in action potential-induced presynaptic Ca(2 (zeige CA2 ELISA Kits)+) transients (somatostatin (zeige SST ELISA Kits)-positive synapses).
Alternative splicing of presynaptic neurexin-3 controls postsynaptic AMPA (zeige GRIA3 ELISA Kits) receptor trafficking, revealing an unanticipated alternative splicing mechanism for trans-synaptic regulation of synaptic strength and long-term plasticity.
N-terminal sequencing of cow neurexin III beta provides evidence for signal peptide
N-terminal sequencing of rat neurexin III alpha provides evidence for signal peptide
NRXN3 adhesion molecules may play an important role in the synaptic plasticity of neurons involved in the indirect pathways of basal ganglia
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences.
, neurexin 3
, protocadherin alpha 12