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Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination.
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Human Monoclonal NLK Primary Antibody für WB - ABIN1882269
Ohkawara, Shirakabe, Hyodo-Miura, Matsuo, Ueno, Matsumoto, Shibuya: Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. in Genes & development 2004
Show all 4 Pubmed References
the promoters of WIF1 (zeige WIF1 Antikörper), NLK, and APC (zeige APC Antikörper) are highly methylated in the nasopharyngeal cancers (NPC (zeige NPC1 Antikörper)) and gastric carcinoma (GC) cell lines, and the 3 genes are also regulated by miR (zeige MLXIP Antikörper)-BART19-3p expressed by Epstein-Barr virus (EBV); expression of the WIF1 (zeige WIF1 Antikörper), APC (zeige APC Antikörper), and NLK genes is strongly affected by hypermethylation, and in EBV-associated tumors, the 3 genes are also affected by miR (zeige MLXIP Antikörper)-BART19-3p
overexpression of miR (zeige MLXIP Antikörper)-221 decreased LEF1 (zeige LEF1 Antikörper) phosphorylation but increased the expression of MYCN (zeige MYCN Antikörper) via targeting of NLK and further regulated cell cycle, particularly in S-phase. This study provides a novel insight for miR (zeige MLXIP Antikörper)-221 in the control of neuroblastoma (zeige ARHGEF16 Antikörper) cell proliferation and tumorigenesis, suggesting potentials of miR (zeige MLXIP Antikörper)-221 as a prognosis marker and therapeutic target for patients with MYCN (zeige MYCN Antikörper) overexpressing neuroblastoma (zeige ARHGEF16 Antikörper).
our data suggest that NLK/Nemo (zeige IKBKG Antikörper) acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie (zeige YAP1 Antikörper).
NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis
Our results suggest that NLK inhibits transcriptional activation of Nurr1 (zeige NR4A2 Antikörper) gene by impeding CBP's role as a co-activator of NF-kappaB (zeige NFKB1 Antikörper) and CREB (zeige CREB1 Antikörper) in prostate cancer.
The expression of NLK was negatively correlated with TCF4 (zeige TCF4 Antikörper) expression in lung cancers
NLK overexpression is an independent prognostic factor in colorectal cancer and knockdown of NLK expression inhibits colorectal cancer progression and metastasis.
Further experiments demonstrated that the overexpression of miR3623p resulted in decrease expression levels of nemo-like kinase
NLK was involved in miR (zeige MLXIP Antikörper)-92b-induced cell proliferation, and its protein level was obviously downregulated in the miR (zeige MLXIP Antikörper)-92b-overexpressing xenograft tumors.
Data show that metformin inhibits nemo like kinase (NLK) expression and might be a potential treatment strategy for non-small cell lung cancer (NSCLC).
NLK can phosphorylate the mutant polyglutamine-expanded androgen receptor (zeige AR Antikörper) protein, enhance its aggregation, and promote androgen receptor (zeige AR Antikörper)-dependent gene transcription by regulating androgen receptor (zeige AR Antikörper)-cofactor interactions.
Nlk is a negative regulator of skeletal homeostasis.
either reducing NLK enzymatic activity or decreasing NLK expression levels can have beneficial effects against the toxicity induced by polyglutamine-expanded ATXN1 (zeige ATXN1 Antikörper)
NEMO (zeige IKBKG Antikörper) binding domain peptide treatment results in improved generation of specific force and greater resistance to lengthening activations in dystrophic diaphragm muscle ex vivo.
Nlk suppresses osteoblastogenesis by opposing BMP/Smad (zeige SMAD1 Antikörper) and WNT (zeige WNT2 Antikörper) canonical signaling
Wnt3a (zeige WNT3A Antikörper) stimulation led to an increase in the interaction of TAB2 (zeige TAB2 Antikörper) with NLK and the formation of a TAK1 (zeige NR2C2 Antikörper).TAB2 (zeige TAB2 Antikörper).NLK complex, suggesting that this TAK1 (zeige NR2C2 Antikörper)-TAB2 (zeige TAB2 Antikörper)-NLK pathway may constitute a negative feedback mechanism for canonical Wnt (zeige WNT2 Antikörper) signaling.
NLK negatively regulates osteoblastic differentiation.
NLK negatively regulates Notch (zeige NOTCH1 Antikörper)-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.
Nanog (zeige NANOG Antikörper) suppresses the expression of vasa (zeige DDX4 Antikörper) by directly regulating nlk1 in the early zebrafish embryo
nlk strongly enhances convergent/extension phenotypes, suggesting a role in modulating cell movements as well as cell fate.
NLK1 acts as a kinase by catalyzing phosphorylation of pumilio (Pum)1, Pum2, and cytoplasmic polyadenylation element binding protein 1 (CPEB) to regulate translation of mRNAs, including cyclin B1 mRNA, stored in oocytes.
These results provide the first evidence that p38 (zeige MAPK14 Antikörper) specifically regulates NLK function, which is required for anterior formation in Xenopus development.
These data show that porcine epidemic diarrhea virus nsp5 (zeige SPECC1 Antikörper) disrupts type I interferon (zeige IFNA Antikörper) signaling by cleaving NEMO (zeige IKBKG Antikörper).
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).
, autocrine motility factor
, glucose phosphate isomerase
, phosphoglucose isomerase
, phosphohexose isomerase
, serine/threonine-protein kinase NLK
, nemo-like kinase
, serine/threonine protein kinase NLK
, nemo like kinase b
, nemo-like kinase 2
, Nemo-like kinase
, Serine/threonine-protein kinase NLK
, nemo like kinase
, Nemo-Like kinase
, serine/threonine-protein kinase NLK-like