anti-Nemo-Like Kinase (NLK) Antikörper

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Ratte NLK NLK 292804 Q6P6V0
Anti-Human NLK NLK 51701 Q9UBE8
Anti-Maus NLK NLK 18099 O54949
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Top anti-Nemo-Like Kinase Antikörper auf antikoerper-online.de

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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-NLK Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>293T cell lysate WB Suggested Anti-NLK <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control:.93T cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-NLK Pab (ABIN391786) in A375 cell lysate. NLK (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert FACS, IF, WB NLK-T286 (ABIN652357) western blot analysis in Y79 cell line lysates (35 µg/lane).This demonstrates the NLK antibody detected the NLK protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image NLK antibody [N3C3] detects NLK protein at cytosol and nucleus on mouse ovary by immunohistochemical analysis. Sample: Paraffin-embedded mouse ovary. NLK antibody [N3C3] , dilution: 1:500. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of anti-NLK Pab in A375 cell lysate. NLK (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Mouse Nlk Antibody (C-term) (ABIN657850) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the Nlk antibody detected the Nlk protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Maus Unkonjugiert WB NLK Antibody (ABIN1882269) western blot analysis in SiHa,Hela cell line lysates (35 µg/lane). This demonstrates the NLK antibody detected the NLK protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert PLA, ELISA, WB NLK monoclonal antibody (M02), clone 2B11 Western Blot analysis of NLK expression in HepG2 NLK monoclonal antibody (M02), clone 2B11. Western Blot analysis of NLK expression in NIH/3T3 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details

Am meisten referenzierte anti-Nemo-Like Kinase Antikörper

  1. Human Monoclonal NLK Primary Antibody für WB - ABIN1882269 : Ohkawara, Shirakabe, Hyodo-Miura, Matsuo, Ueno, Matsumoto, Shibuya: Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. in Genes & development 2004 (PubMed)
    Show all 4 Pubmed References

Weitere Antikörper gegen Nemo-Like Kinase Interaktionspartner

Human Nemo-Like Kinase (NLK) Interaktionspartner

  1. the promoters of WIF1 (zeige WIF1 Antikörper), NLK, and APC (zeige APC Antikörper) are highly methylated in the nasopharyngeal cancers (NPC (zeige NPC1 Antikörper)) and gastric carcinoma (GC) cell lines, and the 3 genes are also regulated by miR (zeige MLXIP Antikörper)-BART19-3p expressed by Epstein-Barr virus (EBV); expression of the WIF1 (zeige WIF1 Antikörper), APC (zeige APC Antikörper), and NLK genes is strongly affected by hypermethylation, and in EBV-associated tumors, the 3 genes are also affected by miR (zeige MLXIP Antikörper)-BART19-3p

  2. overexpression of miR (zeige MLXIP Antikörper)-221 decreased LEF1 (zeige LEF1 Antikörper) phosphorylation but increased the expression of MYCN (zeige MYCN Antikörper) via targeting of NLK and further regulated cell cycle, particularly in S-phase. This study provides a novel insight for miR (zeige MLXIP Antikörper)-221 in the control of neuroblastoma (zeige ARHGEF16 Antikörper) cell proliferation and tumorigenesis, suggesting potentials of miR (zeige MLXIP Antikörper)-221 as a prognosis marker and therapeutic target for patients with MYCN (zeige MYCN Antikörper) overexpressing neuroblastoma (zeige ARHGEF16 Antikörper).

  3. our data suggest that NLK/Nemo (zeige IKBKG Antikörper) acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie (zeige YAP1 Antikörper).

  4. NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis

  5. Our results suggest that NLK inhibits transcriptional activation of Nurr1 (zeige NR4A2 Antikörper) gene by impeding CBP's role as a co-activator of NF-kappaB (zeige NFKB1 Antikörper) and CREB (zeige CREB1 Antikörper) in prostate cancer.

  6. The expression of NLK was negatively correlated with TCF4 (zeige TCF4 Antikörper) expression in lung cancers

  7. NLK overexpression is an independent prognostic factor in colorectal cancer and knockdown of NLK expression inhibits colorectal cancer progression and metastasis.

  8. Further experiments demonstrated that the overexpression of miR3623p resulted in decrease expression levels of nemo-like kinase

  9. NLK was involved in miR (zeige MLXIP Antikörper)-92b-induced cell proliferation, and its protein level was obviously downregulated in the miR (zeige MLXIP Antikörper)-92b-overexpressing xenograft tumors.

  10. Data show that metformin inhibits nemo like kinase (NLK) expression and might be a potential treatment strategy for non-small cell lung cancer (NSCLC).

Mouse (Murine) Nemo-Like Kinase (NLK) Interaktionspartner

  1. our data suggest that NLK/Nemo (zeige IKBKG Antikörper) acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie (zeige YAP1 Antikörper).

  2. NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis

  3. NLK can phosphorylate the mutant polyglutamine-expanded androgen receptor (zeige AR Antikörper) protein, enhance its aggregation, and promote androgen receptor (zeige AR Antikörper)-dependent gene transcription by regulating androgen receptor (zeige AR Antikörper)-cofactor interactions.

  4. Nlk is a negative regulator of skeletal homeostasis.

  5. either reducing NLK enzymatic activity or decreasing NLK expression levels can have beneficial effects against the toxicity induced by polyglutamine-expanded ATXN1 (zeige ATXN1 Antikörper)

  6. NEMO (zeige IKBKG Antikörper) binding domain peptide treatment results in improved generation of specific force and greater resistance to lengthening activations in dystrophic diaphragm muscle ex vivo.

  7. Nlk suppresses osteoblastogenesis by opposing BMP/Smad (zeige SMAD1 Antikörper) and WNT (zeige WNT2 Antikörper) canonical signaling

  8. Wnt3a (zeige WNT3A Antikörper) stimulation led to an increase in the interaction of TAB2 (zeige TAB2 Antikörper) with NLK and the formation of a TAK1 (zeige NR2C2 Antikörper).TAB2 (zeige TAB2 Antikörper).NLK complex, suggesting that this TAK1 (zeige NR2C2 Antikörper)-TAB2 (zeige TAB2 Antikörper)-NLK pathway may constitute a negative feedback mechanism for canonical Wnt (zeige WNT2 Antikörper) signaling.

  9. NLK negatively regulates osteoblastic differentiation.

  10. NLK negatively regulates Notch (zeige NOTCH1 Antikörper)-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.

Zebrafish Nemo-Like Kinase (NLK) Interaktionspartner

  1. Nanog (zeige NANOG Antikörper) suppresses the expression of vasa (zeige DDX4 Antikörper) by directly regulating nlk1 in the early zebrafish embryo

  2. NLK negatively regulates Notch (zeige NOTCH1 Antikörper)-dependent transcriptional activation by phosphorylating Notch1ICD. Phosphorylated Notch1ICD is impaired in its ability to form a transcriptionally active ternary complex.

  3. nlk strongly enhances convergent/extension phenotypes, suggesting a role in modulating cell movements as well as cell fate.

Xenopus laevis Nemo-Like Kinase (NLK) Interaktionspartner

  1. NLK1 acts as a kinase by catalyzing phosphorylation of pumilio (Pum)1, Pum2, and cytoplasmic polyadenylation element binding protein 1 (CPEB) to regulate translation of mRNAs, including cyclin B1 mRNA, stored in oocytes.

  2. These results provide the first evidence that p38 (zeige MAPK14 Antikörper) specifically regulates NLK function, which is required for anterior formation in Xenopus development.

Pig (Porcine) Nemo-Like Kinase (NLK) Interaktionspartner

  1. These data show that porcine epidemic diarrhea virus nsp5 (zeige SPECC1 Antikörper) disrupts type I interferon (zeige IFNA Antikörper) signaling by cleaving NEMO (zeige IKBKG Antikörper).

Nemo-Like Kinase (NLK) Antigen-Profil

Protein Überblick

Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).

Genbezeichner und Symbole assoziert mit anti-Nemo-Like Kinase (NLK) Antikörper

  • glucose-6-phosphate isomerase (Gpi) Antikörper
  • nemo like kinase (NLK) Antikörper
  • nemo like kinase (Nlk) Antikörper
  • nemo-like kinase, type 1 (nlk1) Antikörper
  • nemo-like kinase L homeolog (nlk.L) Antikörper
  • nemo like kinase (nlk) Antikörper
  • Nemo-Like kinase (nemo-like) Antikörper
  • nemo-like kinase (nlk) Antikörper
  • AI194375 Antikörper
  • Amf Antikörper
  • Gpi1 Antikörper
  • nemo-like Antikörper
  • NLK Antikörper
  • nlk1 Antikörper
  • nlk2 Antikörper
  • nlkb Antikörper
  • RGD1561602 Antikörper
  • Xnlk Antikörper
  • zgc:111875 Antikörper

Bezeichner auf Proteinebene für anti-Nemo-Like Kinase (NLK) Antikörper

NLK , PGI , PHI , autocrine motility factor , glucose phosphate isomerase , neuroleukin , phosphoglucose isomerase , phosphohexose isomerase , serine/threonine-protein kinase NLK , nemo-like kinase , serine/threonine protein kinase NLK , nemo like kinase b , nemo-like kinase 2 , Nemo-like kinase , Serine/threonine-protein kinase NLK , nemo like kinase , Nemo-Like kinase , serine/threonine-protein kinase NLK-like

GENE ID SPEZIES
292804 Rattus norvegicus
51701 Homo sapiens
18099 Mus musculus
405892 Danio rerio
414522 Xenopus laevis
417669 Gallus gallus
445934 Takifugu rubripes
491160 Canis lupus familiaris
507204 Bos taurus
677693 Macaca mulatta
739132 Pan troglodytes
778685 Ciona intestinalis
100019356 Monodelphis domestica
100058876 Equus caballus
100144638 Xenopus (Silurana) tropicalis
100348930 Oryctolagus cuniculus
100414864 Callithrix jacchus
100469296 Ailuropoda melanoleuca
100511657 Sus scrofa
100560802 Anolis carolinensis
100593981 Nomascus leucogenys
497961 Rattus norvegicus
100729077 Cavia porcellus
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