NUAK Family, SNF1-Like Kinase, 1 Proteine (NUAK1)

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Zusätzlich bieten wir Ihnen NUAK1 Antikörper (103) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NUAK1 9891 O60285
NUAK1 77976 Q641K5
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Insektenzellen Human His-GST 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$1,502.67
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$656.00
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Escherichia coli (E. coli) Maus GST tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$688.00
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Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$363.67
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Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
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NUAK1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu NUAK Family, SNF1-Like Kinase, 1 (NUAK1) Interaktionspartnern

Human NUAK Family, SNF1-Like Kinase, 1 (NUAK1) Interaktionspartner

  1. Confirmation studies (step 4) provided additional evidence that NUAK1 and STK11 have PTEN-SSL patterns of activity. Consistent with PTEN-SSL status, inhibition of the NUAK1 protein kinase by the small molecule drug HTH-01-015 selectively impaired viability in multiple PTEN-deficient breast cancer cell lines, while mutations affecting STK11 and PTEN were largely mutually exclusive across large pan-cancer data sets.

  2. High NUAK1 expression is associated with cancer.

  3. NUAK1 is excessively expressed in NPC and may serve as a potential predictor of prognosis for NPC.

  4. The elevated ARK5 expression was closely associated with cancer metastasis and patient survival, and it seemed to function in Gastric Cancer cells migration and invasion via epithelial-mesenchymal transition alteration, together with the alteration of the mTOR/p70S6k signals, Slug and SIP1.

  5. ARK5 confers doxorubicin resistance in hepatocellular carcinoma by inducing epithelial-mesenchymal transition.

  6. Nuak1 downregulation decreases tau levels in a human cell line.

  7. High NUAK1 expression are correlated with epithelial-mesenchymal transition induction in head and neck cancer.

  8. ARK5 was upregulated in ovarian cancer tissues, promoted epithelialmesenchymal transition and inhibited miR-1181 expression in ovarian cancer cells

  9. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma.

  10. Overexpression of NUAK1 is associated with disease-free survival and overall survival in patients with gastric cancer.

  11. Data indicate that miR-96 suppresses the expression of (nua) kinase family 1 (NUAK1) by targeting its 3' untranslated region (3' UTR).

  12. Results indicate that NUAK1 is excessively expressed in NSCLC and plays important roles in NSCLC invasion.

  13. Expression of NUAK1 is controlled by cyclin-dependent kinase, PLK1, and the SCFbetaTrCP (Skp, Cullin and F-boxbetaTrCP) E3 ubiquitin ligase complex.

  14. We demonstrate that miR-211 contributes to melanoma adhesion by directly targeting a gene, NUAK1.

  15. Overexpression of ARK5 is associated with hepatocellular carcinoma.

  16. High NUAK1 expression correlates with poor prognosis and involved in human nonsmall cell lung cancer cells migration and invasion.

  17. ARK5 can promote glioma cell invasion by regulating cytoskeleton rearrangement and matrix metalloproteinase activation.

  18. in human and murine cell lines, oncogenic levels of MYC establish a dependence on AMPK-related kinase 5 for maintaining metabolic homeostasis and for cell survival; ARK5 is an upstream regulator of AMPK and limits protein synthesis via inhibition of the mammalian target of rapamycin 1 (mTORC1) signalling pathway

  19. ARK5 enhanced the invasive and metastatic potential of MDA-MB-231 cells under regulation by Akt.

  20. NUAK1 and PPP1CC are identified as positional candidate loci for skeletal muscle strength phenotypes.

Mouse (Murine) NUAK Family, SNF1-Like Kinase, 1 (NUAK1) Interaktionspartner

  1. NUAK1 haploinsufficiency impairs mouse cortical development.

  2. The findings define the PI3K/NUAK1/MYPT1/MLCP axis as a critical pathway to regulate actomyosin contractility in endothelial cells, supporting vascular patterning and expansion through the control of cell rearrangement.

  3. Knockdown of ARK5 expression remarkably suppressed Gastric Cancer cells invasion and metastasis via regulating epithelial-mesenchymal transition, rather than proliferation in vitro and in vivo.

  4. Nuak1 haploinsufficiency rescued the phenotypes of a tauopathy mouse model.

  5. Study shows that LKB1 is necessary and sufficient for terminal axon branching of cortical neurons through the activation of NUAK1, an AMPK-related kinase whose function during brain development was unknown.

  6. NUAK1 knockdown reduced lung metastasis in a xenograft mouse model of nonsmall cell lung cancer.

  7. NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.

  8. in human and murine cell lines, oncogenic levels of MYC establish a dependence on AMPK-related kinase 5 for maintaining metabolic homeostasis and for cell survival; ARK5 is an upstream regulator of AMPK and limits protein synthesis via inhibition of the mammalian target of rapamycin 1 (mTORC1) signalling pathway

  9. a physiological role of NUAK1 is to suppress glucose uptake through negative regulation of insulin signaling in oxidative muscle.

  10. Omphk1 expression is also found in each tissue associated with the ventral body wall closure: the primary body wall composed of primitive ectoderm and each component of the secondary body wall [Omphk1]

NUAK1 Protein Überblick

Protein Überblick

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.

Genbezeichner und Symbole assoziert mit NUAK1

  • NUAK family kinase 1 (NUAK1)
  • NUAK family, SNF1-like kinase, 1 (Nuak1)
  • ARK5 Protein
  • AU014801 Protein
  • AW494241 Protein
  • B230104P22Rik Protein
  • Omphk1 Protein

Bezeichner auf Proteinebene für NUAK1

AMP-activated protein kinase family member 5 , AMPK-related protein kinase 5 , NUAK family SNF1-like kinase 1 , omphalocele kinase 1 , ZNUAK family, SNF1-like kinase, 1

GENE ID SPEZIES
9891 Homo sapiens
77976 Mus musculus
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