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Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Zusätzlich bieten wir Ihnen NUAK1 Antikörper (100) und und viele weitere Produktgruppen zu diesem Protein an.
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The elevated ARK5 expression was closely associated with cancer metastasis and patient survival, and it seemed to function in Gastric Cancer cells migration and invasion via epithelial-mesenchymal transition alteration, together with the alteration of the mTOR/p70S6k signals, Slug and SIP1.
ARK5 confers doxorubicin resistance in hepatocellular carcinoma by inducing epithelial-mesenchymal transition.
Nuak1 downregulation decreases tau levels in a human cell line.
High NUAK1 expression are correlated with epithelial-mesenchymal transition induction in head and neck cancer.
ARK5 was upregulated in ovarian cancer tissues, promoted epithelialmesenchymal transition and inhibited miR (zeige MLXIP Proteine)-1181 expression in ovarian cancer cells
MiR (zeige MLXIP Proteine)-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma.
Overexpression of NUAK1 is associated with disease-free survival and overall survival in patients with gastric cancer.
Data indicate that miR-96 suppresses the expression of (nua) kinase family 1 (NUAK1) by targeting its 3' untranslated region (3' UTR).
Results indicate that NUAK1 is excessively expressed in NSCLC and plays important roles in NSCLC invasion.
Expression of NUAK1 is controlled by cyclin-dependent kinase (zeige CDK1 Proteine), PLK1, and the SCFbetaTrCP (Skp, Cullin and F-boxbetaTrCP) E3 ubiquitin ligase (zeige MUL1 Proteine) complex.
Knockdown of ARK5 expression remarkably suppressed Gastric Cancer cells invasion and metastasis via regulating epithelial-mesenchymal transition, rather than proliferation in vitro and in vivo.
Nuak1 haploinsufficiency rescued the phenotypes of a tauopathy mouse model.
Study shows that LKB1 (zeige STK11 Proteine) is necessary and sufficient for terminal axon branching of cortical neurons through the activation of NUAK1, an AMPK (zeige PRKAA1 Proteine)-related kinase whose function during brain development was unknown.
NUAK1 knockdown reduced lung metastasis in a xenograft mouse model of nonsmall cell lung cancer.
NUAK1 and NUAK2 (zeige NUAK2 Proteine) complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.
in human and murine cell lines, oncogenic levels of MYC (zeige MYC Proteine) establish a dependence on AMPK (zeige PRKAA1 Proteine)-related kinase 5 for maintaining metabolic homeostasis and for cell survival; ARK5 is an upstream regulator of AMPK (zeige PRKAA1 Proteine) and limits protein synthesis via inhibition of the mammalian target of rapamycin (zeige FRAP1 Proteine) 1 (mTORC1) signalling pathway
a physiological role of NUAK1 is to suppress glucose uptake through negative regulation of insulin (zeige INS Proteine) signaling in oxidative muscle.
Omphk1 expression is also found in each tissue associated with the ventral body wall closure: the primary body wall composed of primitive ectoderm and each component of the secondary body wall [Omphk1]
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
AMP-activated protein kinase family member 5
, AMPK-related protein kinase 5
, NUAK family SNF1-like kinase 1
, omphalocele kinase 1
, ZNUAK family, SNF1-like kinase, 1