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NLRX1 encodes a member of the NLR family. Zusätzlich bieten wir Ihnen NLRX1 Antikörper (70) und und viele weitere Produktgruppen zu diesem Protein an.
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genetic association studies in Han population in southern China: Data suggest that, in subjects with type 2 diabetes, an SNP in NLRX1 (rs4245191) is associated with macro-vascular complications and cerebral infarction in the population studied; no such association was found for two other SNPs in NLRX1 (rs10790286, rs561830) or for two SNPs in TRAF6 (zeige TRAF6 ELISA Kits) (rs5030445, rs16928973). (TRAF6 (zeige TRAF6 ELISA Kits) = TNF receptor associated factor-6 (zeige TRAF6 ELISA Kits))
Data show that NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma.
NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 (zeige IRF1 ELISA Kits) and IRF3 (zeige IRF3 ELISA Kits). NLRX1 suppressed MAVS (zeige MAVS ELISA Kits)-mediated activation of IRF3 (zeige IRF3 ELISA Kits), it conversely facilitated virus-induced increases in IRF1 (zeige IRF1 ELISA Kits) expression and thereby enhanced control of viral infection.
downregulated in brain injury following aneurysm
The data suggests that NLRX1 plays a positive role in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by suppressing the IFNbeta response during the process of KSHV reactivation, which might serve as a potential target for restricting KSHV replication and transmission.
we identify a novel signaling hub centering on the NLRX1 TUFM (zeige Tufm ELISA Kits) protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM (zeige Tufm ELISA Kits) result in compromised autophagy when treated with EGFR (zeige EGFR ELISA Kits) inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR (zeige EGFR ELISA Kits) inhibitors.
findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis
NLRX1, NLRP12 and NLRC3 negatively modulate the host immune response following virus exposure. (Review)
NLRX1 acts as a potential tumor suppressor by regulating the TNF-alpha (zeige TNF ELISA Kits) induced cell death and metabolism.
These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS (zeige MAVS ELISA Kits)/RHL (zeige DDX46 ELISA Kits) activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses.
NLRX1 function extends to the control of hepatocyte energy metabolism via the restriction of mitochondrial fatty acid-dependent OXPHOS and enhancement of glycolysis.
NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma
Nlrx1-/- mice exhibited significantly larger brain lesions and increased motor deficits following controlled cortical impact injury
this in vitro studies show that NLRX1-deficient T cells have a greater ability to differentiate into an inflammatory phenotype and possess greater proliferation rates
NLRX1 sequesters the DNA-sensing adaptor STING from interaction with TBK1 (zeige TBK1 ELISA Kits), which is a requisite for IFN-1 induction in response to viral DNA.
NLRX1 diminishes Tumor Necrosis Factor-alpha (zeige TNF ELISA Kits)-induced activation of both Akt (zeige AKT1 ELISA Kits)- and NF-kappaB (zeige NFKB1 ELISA Kits)-dependent pathways. Since Akt (zeige AKT1 ELISA Kits) was shown to be essential for Tumor Necrosis Factor-alpha (zeige TNF ELISA Kits)-mediated activation of NF-kappaB (zeige NFKB1 ELISA Kits) it is likely that the primary effect of NLRX1 is at the level of C-Akt (zeige AKT1 ELISA Kits) proein signaling.
NLRX1 attenuated Apc (zeige APC ELISA Kits)(min/+) colon tumorigenesis, cellular proliferation, NF-KappaB (zeige NFKB1 ELISA Kits), mitogen-activated protein kinase (zeige MAPK1 ELISA Kits), signal transducer and activator of transcription 3 (zeige STAT3 ELISA Kits) activation, and interleukin 6 (zeige IL6 ELISA Kits) levels.
NLRX1 may relate to hair cell maturity, hearing formation and maintenance, and promote hair cell apoptosis through JNK (zeige MAPK8 ELISA Kits) pathway
The regulatory role of NLRX1 in mechanisms of host tolerance employed by macrophages to respond to Helicobacter pylori infection.NLRX1 modulates innate immune responses to Helicobacter pylori infection.
Nlrx1 may play an important role in neurodegenerative diseases, where necrosis is a prominent factor.
This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified.
NLR family member X1
, NLR family, X1
, NOD-like receptor X1
, caterpiller protein 11.3
, nucleotide-binding oligomerization domain protein 26
, nucleotide-binding oligomerization domain protein 5
, nucleotide-binding oligomerization domain protein 9
, nucleotide-binding oligomerization domain, leucine rich repeat containing X1
, nucleotide-binding domain and leucine-rich repeat containing