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The protein encoded by NLRP6 binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance.
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this review discuss recent findings related to NLRP6 activity, while highlighting outstanding questions and future perspectives in elucidating its roles in health and disease
Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2 (zeige TAB2 Antikörper)/3 and TRIM38 (zeige TRIM38 Antikörper) in RA synoviocytes in response to TNFalpha (zeige TNF Antikörper). (NLRP6 = ; TAB2 (zeige TAB2 Antikörper)/3 = transforming growth factor-b (zeige ATP5S Antikörper)-activated kinase 1-binding protein 2/3; TRIM38 (zeige TRIM38 Antikörper) = tripartite motif 38)
Our results revealed an association between NLRP6/AVR and ADM (zeige ADM Antikörper) loci with male essential hypertension, suggesting the existence of sex-specific NLRP6/AVR and ADM (zeige ADM Antikörper) variants affecting male susceptibility to essential hypertension.
We will focus on NLRP6 and NLRP12 (zeige NLRP12 Antikörper).
NLRP6 is a newly characterized member of this family that inhibits NF-kappaB (zeige NFKB1 Antikörper) and MAP-kinase (zeige MAPK1 Antikörper) dependent immune signaling to hamper anti-microbial defense.
AVR is distinct from Nalp6/PYPAF5 based on different mRNA and protein sizes, subcellular localization, and tissue-specific expression patterns.
The dual AngII/AVP (zeige AVP Antikörper) receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model.
This publication deals with the rat ortholog of the human NLRP6 gene.
A. actinomycetemcomitans enhances NLRP3 (zeige NLRP3 Antikörper) and reduces NLRP6 inflammasome expression.
NLRP6 is important for suppressing the development of spontaneous colitis in the Il10 (zeige IL10 Antikörper) (-/-) inflammatory bowel disease model and NLRP6 deficiency results in the enrichment of Akkermansia muciniphila.
these data reveal a previously unappreciated role for NLRP6 in inflammatory monocytes, which are recruited after dextran sodium sulfate-induced intestinal injury to promote barrier function and limit bacteria-driven inflammation
this study shows that Nlrp6-dependent Inflammasomes do not shape the commensal gut (zeige GUSB Antikörper) microbiota composition
Study identified a set of microbiota-modulated metabolites whose integrative activity drives NLRP6 inflammasome activation and downstream epithelial IL-18 (zeige IL18 Antikörper)-induced anti-microbial peptide secretion, thereby providing favorable conditions for WT microbiota colonization.
Nlrp6 contributes to recovery from peripheral nerve injury by dampening inflammatory responses independently of IL-1beta (zeige IL1B Antikörper) and inflammasomes
These data demonstrate that Nlrp6 functions with Dhx15 (zeige DHX15 Antikörper) as a viral RNA sensor to induce IFN-stimulated genes , and this effect is especially important in the intestinal tract.
Study demonstrates that NLRP6 is important in maintaining autophagy in the intestinal epithelium, a process previously shown to be critically important in intestinal granule exocytosis pathway.
Exposure of mice to stress inhibits NLRP6 and alters the composition of the gut (zeige GUSB Antikörper) microbiota, leading to intestinal inflammation.
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation.
NLR family, pyrin domain containing 6
, NACHT, leucine rich repeat and PYD containing 6
, NLR family pyrin domain-containing protein 6
, NACHT, LRR and PYD domains-containing protein 6-like
, NACHT, LRR and PYD containing protein 6
, NACHT, LRR and PYD domains-containing protein 6
, PYRIN-containing APAF1-like protein 5
, angiotensin II/vasopressin receptor
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6
, NACHT/LRR/pyrin domain-containing protein 6
, non-angiotensin-vasopressin receptor
, angiotensin/vasopressin receptor
, dual angiotensin II/vasopressin receptor