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NEK8 encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. Zusätzlich bieten wir Ihnen NEK8 Antikörper (84) und viele weitere Produktgruppen zu diesem Protein an.
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NEK8 (zeige NEK9 Proteine) plays a critical role in replication fork stability through its regulation of the DNA repair and replication fork protection protein RAD51 (zeige RAD51 Proteine).
The mutations: c.2069_2070insC variant (p.Ter693LeufsTer86), and a c.1043C>T variant (p.Thr348Met) in RCC1 (zeige RCC1 Proteine) domain of NEK8 (zeige NEK9 Proteine) in two brothers with cardiac, renal, and hepatic anomalies
our study demonstrates that NEK8 (zeige NEK9 Proteine) human mutations cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway
NEK8 (zeige NEK9 Proteine) may be a new target gene of HIFs; pVHL (zeige VHL Proteine) can down-regulate NEK8 (zeige NEK9 Proteine) via HIFs to maintain the primary cilia structure in human renal cancer cells
NEK8 (zeige NEK9 Proteine) is essential for organ development and that the complete loss of NEK8 (zeige NEK9 Proteine) perturbs multiple signalling pathways resulting in a severe early embryonic phenotype.
Mutation in NEK8 (zeige NEK9 Proteine) is associated with renal ciliopathies
ANKS6 as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8 (zeige NEK9 Proteine), INVS (zeige INVS Proteine) and NPHP3 (zeige NPHP3 Proteine).
NPHP9 promotes signalling through the transcriptional co-activator TAZ (zeige TAZ Proteine).
study finds that induction of ciliogenesis upon cell cycle exit is accompanied by both activation and proteasomal degradation of Nek8 (zeige NEK9 Proteine), and that activation is dependent upon phosphorylation within the catalytic domain
Data demonstrate for the first time that Nek8 (zeige NEK9 Proteine) is a novel tumor associated gene, and shares considerable sequence homology with the Nek family of protein kinases and may be involved in G(2)/M progression.
requirement for Nek8 in left-right patterning is conserved
Nek8 acts downstream of Inv (zeige INVS Proteine) function
cross-species analysis between zebrafish and mouse demonstrates taht NEK8 has a role in development of pronephric cysts
We constructed sub-congenic lines to more specifically localize the modifier and have determined it resides in a 3.2 Mb interval containing 28 genes. These include Invs (zeige INVS Proteine) and Anks6, which are both excellent candidates for the modifier as mutations in these genes result in PKD (zeige PRKD1 Proteine) and both genes are known to genetically and physically interact with Nek8.
NEK8 plays a critical role in replication fork stability through its regulation of the DNA repair and replication fork protection protein RAD51 (zeige RAD51 Proteine).
NEK8-depleted inner medullary collecting duct cells exhibited a defective response to fluid shear.
Inv (zeige INVS Proteine) acts as a molecular anchor for Nphp3 (zeige NPHP3 Proteine) and Nek8 in the proximal segment of primary cilia.
Nek8 and Pkd1 (zeige PKD1 Proteine) genes function in a common pathway to regulate cystogenesis. Moreover, compound Pkd1 (zeige PKD1 Proteine) and Nek8 heterozygous adult mice develop a more aggressive cystic disease than animals with a mutation in either gene alone.
Defects in ciliary localization of Nek8 is associated with polycystic kidney diseases
This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.
NIMA (never in mitosis gene a)- related kinase 9
, NIMA-related kinase Nek8
, nercc1 kinase
, never in mitosis A-related kinase 9
, nimA-related kinase 8
, nimA-related protein kinase 9
, serine/threonine-protein kinase Nek9
, NIMA (never in mitosis gene a)- related kinase 8
, NIMA-family kinase NEK8
, NIMA-related kinase 12a
, nephrocystin 9
, never in mitosis A-related kinase 8
, nimA-related protein kinase 8
, nima-related protein kinase 12a
, serine/threonine-protein kinase Nek8
, serine/thrionine-protein kinase NEK8
, NIMA-related kinase 8
, NIMA (never in mitosis gene a)-related expressed kinase 8
, NIMA-related expressed kinase 8
, juvenile cystic kidney