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The protein encoded by NEK6 is a kinase required for progression through the metaphase portion of mitosis. Zusätzlich bieten wir Ihnen NEK6 Antikörper (73) und viele weitere Produktgruppen zu diesem Protein an.
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NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.
NEK6 (zeige NEK5 Proteine) forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.
cis (zeige CISH Proteine)-regulatory circuits that lead to overexpression of NEK6, a mitosis-associated kinase, in human B cell lymphoma, were analyzed.
High NEK6 expression is associated with Cluster Amplified Centrosomes in cancer.
Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis.
our studies establish NEK6 signaling as a central mechanism mediating castration-resistant prostate cancer
overexpression of PAK1 (zeige PAK1 Proteine), NEK6, AURKA (zeige AURKA Proteine), and AURKB (zeige AURKB Proteine) genes in patients with Colorectal adenomatous polyp and colorectal cancer in the Turkish population.
We found that NEK6-mediated phosphorylation of TPP1 (zeige TPP1 Proteine) Ser255 in G2/M phase regulates the association between telomerase activity and TPP1 (zeige TPP1 Proteine). Furthermore, we found evidence that POT1 (zeige POT1 Proteine) negatively regulates TPP1 (zeige TPP1 Proteine) phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 (zeige POT1 Proteine) mutant lacking its OB-fold domains
Overexpression of AURKA (zeige AURKA Proteine) and NEK6 genes was significantly more pronounced in Ulcerative colitis patients with more extensive colon involvement
NEK6 suppresses the cell growth arrest induced by TGFbeta (zeige TGFB1 Proteine). Mechanically, NEK6 blocks nuclear translocation of Smad4 (zeige SMAD4 Proteine), which is essential for TGFbeta (zeige TGFB1 Proteine) function.
Nek6 is also a critical signaling molecule that helps prevent cardiac hypertrophy and inhibits the Akt (zeige AKT1 Proteine) signaling pathway.
Nek6 facilitates association of Hsp72 (zeige HSPA1A Proteine) with the mitotic spindle, where it promotes stable K-fiber assembly through recruitment of the ch-TOG-TACC3 (zeige TACC3 Proteine) complex.
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene.
NIMA-related expressed kinase 6
, never in mitosis A-related kinase 6
, nimA-related protein kinase 6
, serine/threonine-protein kinase Nek6
, putative serine-threonine protein kinase
, NIMA (never in mitosis gene a)-related kinase 6
, protein kinase SID6-1512
, NIMA (never in mitosis gene a)-related expressed kinase 6