anti-NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) Antikörper

NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. Zusätzlich bieten wir Ihnen NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Proteine (5) und NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
NAB2 17937 Q61127
NAB2 314910  
NAB2 4665 Q15742
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Top anti-NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Antikörper auf antikoerper-online.de

Showing 10 out of 109 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-NAB2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human heart 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Nab2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Mouse Kidney 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit Target Name: NAB2 Sample Tissue: Human Fetal Thymus Antibody Dilution: 1ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IP, IHC (p), WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using NAB2, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: A431 7.5% SDS PAGE antibody diluted at 1:2000 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-NAB2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of NAB2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of NAB2 expression in HepG2 (A), HeLa (B), Raw264.7 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from HT-29/RAW264.7 cells, using NAB2 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using NAB2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of NAB2 antibody (Center) (ABIN391957) in A375 cell line lysates (35 µg/lane). NAB2 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen Verfügbar
$181.73
Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p), WB 50 μL Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details

Weitere Antikörper gegen NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Interaktionspartner

Mouse (Murine) NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) Interaktionspartner

  1. These findings indicate a requirement for Nab2 in maintaining thymocyte number in male mice with age and in response to stress.

  2. Data suggest that histone deacetylase inhibitors inhibit the induction of NGF1A-binding protein Nab2 by brain derived neurotrophic factor (BDNF), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa (DARPP-32).

  3. Nab2 is a novel endogenous negative regulator of Egr-1-dependent TGF-beta signaling responsible for setting the intensity of fibrotic responses

  4. Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.

  5. repression of the endogenous Rad gene by NAB2 involves interaction with the CHD4 (chromodomain helicase DNA-binding protein 4) subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex

  6. NAB2 enhances IL-2 transcription by acting as a coactivator for Egr-1.NAB2 is recruited to the Egr-1 binding site of the IL-2 promoter.

  7. We report here, that FGF23 induces not only Egr-1 but also two isoforms of NAB2, which are specific co-repressors of Egr-1.

  8. Helps control the fate of antigen recognition in T cells.

Human NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) Interaktionspartner

  1. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours.

  2. Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor

  3. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion and helps to discriminate SFTs from histological mimics.

  4. Variants of the NAB2-STAT6 fusion gene are found in solitary fibrous tumors of the meninges.

  5. NAB2-STAT6 fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain.

  6. the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.

  7. Case Report: NAB2-STAT6 fusion in glioblastoma.

  8. We delineate the common and rare NAB2-STAT6 fusion variants in solitary fibrous tumors

  9. This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 nuclear expression and NAB2-STAT6 fusion similar to their soft tissue counterparts.

  10. It is associated with local recurrence and late distance metastasis of brain tumors to extracranial sites.

  11. This study validated the existence of the NAB2-STAT6 fusion gene in solitary fibrous tumors and examined its relation with pathological features.

  12. also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17

  13. There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201).

  14. reverse transcriptase PCR analysis identified a nerve growth factor inducible-A binding protein 2-STAT6 gene fusion. Our case supports the utility of STAT6 immunohistochemistry as an adjunct in the diagnosis of soft-tissue SFT with loss of CD34 positivity

  15. Tumors with the most common fusion variant, NAB2ex4-STAT6ex2/3, corresponded to classic pleuropulmonary solitary fibrous tumors with diffuse fibrosis and mostly benign behavior and occurred in older patients

  16. 44 SFTs were studied to identify pathogenetically important genetic rearrangements. RT-PCR analysis identified a NAB2/STAT6 fusion in 37/41 cases.

  17. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion

  18. NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells.

  19. A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 is the defining driver mutation of solitary fibrous tumor.

  20. A NAB2-STAT6 fusion is a distinct molecular feature of solitary fibrous tumors.

NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) Antigen-Profil

Protein Überblick

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Genbezeichner und Symbole assoziert mit NAB2

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Bezeichner auf Proteinebene für NAB2

NGFI-A binding protein 2 (EGR1 binding protein 2) , EGR-1-binding protein 2 , NGFI-A binding protein 2 (EGR-1 binding protein 2) , NGFI-A-binding protein 2 , EGR1 binding protein 2 , melanoma-associated delayed early response protein

GENE ID SPEZIES
100145178 Xenopus (Silurana) tropicalis
17937 Mus musculus
314910 Rattus norvegicus
4665 Homo sapiens
504755 Bos taurus
481122 Canis lupus familiaris
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