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NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. Zusätzlich bieten wir Ihnen NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Proteine (5) und NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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These findings indicate a requirement for Nab2 in maintaining thymocyte number in male mice with age and in response to stress.
Data suggest that histone deacetylase (zeige HDAC1 Antikörper) inhibitors inhibit the induction of NGF1A-binding protein (zeige NAB1 Antikörper) Nab2 by brain derived neurotrophic factor (BDNF (zeige BDNF Antikörper)), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein (zeige ARPP21 Antikörper), 32 kDa (DARPP-32 (zeige PPP1R1B Antikörper)).
Nab2 is a novel endogenous negative regulator of Egr-1 (zeige EGR1 Antikörper)-dependent TGF-beta (zeige TGFB1 Antikörper) signaling responsible for setting the intensity of fibrotic responses
Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.
repression of the endogenous Rad (zeige RRAD Antikörper) gene by NAB2 involves interaction with the CHD4 (chromodomain helicase DNA-binding protein 4 (zeige CHD4 Antikörper)) subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex
NAB2 enhances IL-2 (zeige IL2 Antikörper) transcription by acting as a coactivator for Egr-1 (zeige EGR1 Antikörper).NAB2 is recruited to the Egr-1 (zeige EGR1 Antikörper) binding site of the IL-2 (zeige IL2 Antikörper) promoter.
We report here, that FGF23 (zeige FGF23 Antikörper) induces not only Egr-1 (zeige EGR1 Antikörper) but also two isoforms of NAB2, which are specific co-repressors of Egr-1 (zeige EGR1 Antikörper).
Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 (zeige STAT6 Antikörper) fusion genes ,the molecular hallmark of solitary fibrous tumours.
Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 (zeige STAT6 Antikörper) gene fusion as was nonmeningeal solitary fibrous tumor
The detection of nuclear relocation of STAT6 (zeige STAT6 Antikörper) with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 (zeige STAT6 Antikörper) fusion and helps to discriminate SFTs from histological mimics.
Variants of the NAB2-STAT6 (zeige STAT6 Antikörper) fusion gene are found in solitary fibrous tumors of the meninges.
NAB2-STAT6 (zeige STAT6 Antikörper) fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain.
the majority of intrathoracic SFTs exhibited STAT6 (zeige STAT6 Antikörper) nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.
Case Report: NAB2-STAT6 (zeige STAT6 Antikörper) fusion in glioblastoma.
We delineate the common and rare NAB2-STAT6 (zeige STAT6 Antikörper) fusion variants in solitary fibrous tumors
This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 (zeige STAT6 Antikörper) nuclear expression and NAB2-STAT6 (zeige STAT6 Antikörper) fusion similar to their soft tissue counterparts.
This study validated the existence of the NAB2-STAT6 (zeige STAT6 Antikörper) fusion gene in solitary fibrous tumors and examined its relation with pathological features.
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
NGFI-A binding protein 2 (EGR1 binding protein 2)
, EGR-1-binding protein 2
, NGFI-A binding protein 2 (EGR-1 binding protein 2)
, NGFI-A-binding protein 2
, EGR1 binding protein 2
, melanoma-associated delayed early response protein