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NKRF encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes.
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vitamin E supplementation affords protection by decreasing MMP-1 (zeige MMP1 Proteine) and increasing PPARg (zeige PPARG Proteine), GSTa (zeige GSTa2 Proteine), and ABCA1 (zeige ABCA1 Proteine) levels in aortae of rabbits fed a cholesterol-rich diet
MIR29 targets and reduces expression of CLDN1 (zeige CLDN1 Proteine) and NKRF to increase intestinal permeability in inflammatory bowel disease.
The data of this study show that JKTBP1 and the 14-nt element act independently to mediate NRF internal ribosome entry segment activity.
NKRF is a nucleolar HSP essential for nucleolus homeostasis and cell survival under proteotoxic stress. NKRF is a thermosensor translocating from the nucleolus to the nucleoplasm during heat stress; nucleolar pools are replenished upon HSF1 (zeige HSF1 Proteine)-mediated NKRF resynthesis. NKRF is an unconventional HSP crucial for correct rRNA processing. Under stress conditions, NKRF directs XRN2 (zeige XRN2 Proteine) nucleolus/nucleoplasm trafficking.
Data suggest that L protein from LCMV interactions with host proteome, specifically DDX3X (zeige DDX3X Proteine), NKRF, and TRIM21 (zeige TRIM21 Proteine). (LCMV = Lymphocytic choriomeningitis mammarenavirus; DDX3X (zeige DDX3X Proteine) = DEAD-box helicase 3; NKRF = NF-kappa-B-repressing factor; TRIM21 (zeige TRIM21 Proteine) = tripartite motif-containing protein-21 (zeige TRIM21 Proteine))
depletion of NKRF, XRN2 (zeige XRN2 Proteine) or DHX15 (zeige DHX15 Proteine) impairs an early pre-rRNA cleavage step.
NF-kappaB-repressing factor (NKRF) phosphorylation modulates promoter-proximal transcription elongation of NF-kappaB (zeige NFKB1 Proteine)/NKRF-regulated genes via direct interactions with elongation complex in response to specific stimuli
The up-regulated NKRF serves as an endogenous repressor for IP-10 (zeige CXCL10 Proteine) and IL-8 (zeige IL8 Proteine) synthesis to hinder host from robust response to MTb (zeige NCAPG2 Proteine) infection.
NRF may serve as an endogenous repressor to prevent robust increase in IP-10/CXCL10 (zeige CXCL10 Proteine) and IL-8/CXCL8 (zeige IL8 Proteine) when TB bacterial load is high.
The expression of NKRF is decreased in PBMCs of patients with stable COPD (zeige ARCN1 Proteine). The downregulation of NKRF was found to be closely related to enhanced IL-8 (zeige IL8 Proteine) production from these peripheral blood cells through de-repression of the IL-8 (zeige IL8 Proteine) promoter.
The results indicate that JKTBP1 regulates the level of NRF protein expression by binding to both NRF 5' and 3' UTRs.
role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants.
NFKB repressing factor
, transcription factor NRF
, NF-kappaB repressing factor
, nkrf (NF-kappaB repressing factor)
, NF-kappa-B-repressing factor-like
, NF-kappa-B-repressing factor
, NFkB-repressing factor