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NOX3 encodes a member of the NOX family of NADPH oxidases.
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Hsp70 (zeige HSP70 ELISA Kits) activates Stat3 (zeige STAT3 ELISA Kits) and suppresses Nox3 via TLR4 (zeige TLR4 ELISA Kits)
Together, these findings reveal that Nox2 (zeige CYBB ELISA Kits) is a Zn(2+)-regulated enzyme that mediates ZnD-induced oxidative stress and kidney hypertrophy. Understanding the specific mechanisms by which ZnD contributes to kidney damage may have an important impact on the treatment of chronic kidney disease.
Nox3 mutants and heterozygotes demonstrated a greater susceptibility to noise-induced hearing loss.
Although Nox3 overexpression revealed no apparent effect, depletion of Nox3 decreased the number of spermatogonial stem cells in both cultured spermatogonia and freshly isolated testis cells.
Mutations of Nox3 include retrovirus insertion, missense mutations, splice donor mutation, a splice acceptor mutation and premature translational termination.
palmitate-induced ROS (zeige ROS1 ELISA Kits) generation and that NOX3-derived ROS (zeige ROS1 ELISA Kits) may drive palmitate-induced hepatic insulin (zeige INS ELISA Kits) resistance through JNK (zeige MAPK8 ELISA Kits) and p38(MAPK (zeige MAPK14 ELISA Kits)) pathways.
an allelic series of mutations at the otoconia-deficient head tilt (het) locus, affecting the gene for NADPH oxidase 3 (Nox3), identifies Nox3 as a protein with a clear enzymatic function indispensable for otoconia morphogenesis
NOX3 is a relevant source of ROS (zeige ROS1 ELISA Kits) generation in the cochlear and vestibular systems and that NOX3-dependent ROS (zeige ROS1 ELISA Kits) generation might contribute to hearing loss and balance problems in response to ototoxic drugs.
genetic variants in NOX3 may confer susceptibility to antithyroid drug-induced apoptosis of granulocytes.
In lung transplants, our study highlights a donor-recipient interaction of NOX3 and NFE2L2 (zeige NFE2L2 ELISA Kits) that increases the risk of PGD (zeige PGD ELISA Kits).
Reduced matrigel invasion was mediated by reduced ROS (zeige ROS1 ELISA Kits) levels coinciding with decreased expression of NADPH oxidase 2 (zeige CYBB ELISA Kits), 3, 4 and 5 involved in ROS (zeige ROS1 ELISA Kits) production.
Down-regulation of NOX3 using siRNA prevented TNF-alpha (zeige TNF ELISA Kits)-induced decrease of cellular glycogen (zeige GYS1 ELISA Kits).
Nox3 is regulated by NOXO1, p47phox, and p67phox
Nox3 functions together with p22(phox) as an enzyme constitutively producing superoxide
Rac1 regulates both oxidases Nox1 (zeige NOX1 ELISA Kits) and Nox3 through the Nox activators
In conclusion, the results demonstrate that NOX3, a reactive oxygen species generating NADPH oxidase (zeige NOX1 ELISA Kits), plays an integral role in insulin (zeige INS ELISA Kits)-induced p42 (zeige EPB42 ELISA Kits)/44 Mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) signal transmission and VEGF-A (zeige VEGFA ELISA Kits) production.
Roles for p22phox at several distinct points in the maturation and assembly of a functionally competent Nox3 in the plasma membrane.
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
, NADPH oxidase catalytic subunit-like 3
, gp91phox homolog 3
, mitogenic oxidase 2
, NADPH oxidase 3
, predicted NADPH oxidase-3
, NADPH oxidase 3-like