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The protein encoded by NECAB3 interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. Zusätzlich bieten wir Ihnen NECAB3 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Results suggest that NECAB3, a novel Mint3-binding protein, activates HIF-1 to promote normoxic glycolysis and tumorigenicity by forming a ternary complex with Mint3 and FIH-1.
hXB51 isoforms regulate Abeta generation differently, either enhancing it by modifying the association of X11L with APP or suppressing it in an X11L-independent manner
xb51 may be required for maturation and maintenance of xb51-expressing neurons in the forebrain
The genes for the three Necab's, including Necab-3, were expressed in specific, non-overlapping areas of the hippocampus.
Physical interactions of Nek2 with NIP1 were confirmed. In fact, Nek2 can phosphorylate NIP1 in vivo. Immunostaining experiments revealed that NIP1 is a Golgi protein.
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.
amyloid beta (A4) precursor protein-binding, family A, member 1 binding protein
, amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein
, N-terminal EF-hand calcium-binding protein 3
, N-terminal EF-hand calcium binding protein 3
, EF-hand calcium binding protein 3
, Nek2-interacting protein 1
, X11L-binding protein 51
, amyloid beta A4 protein-binding family A member 2-binding protein
, neuronal calcium-binding protein 3
, neuronal calcium-binding protein NECAB3
, synaptotagmin interacting protein 2
, synaptotagmin interacting protein STIP3
, amyloid beta (A4) precursor protein-binding family A member 1 binding protein