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NAT1 is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. Zusätzlich bieten wir Ihnen NAT1 Antikörper (88) und NAT1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human NAT1 Protein expressed in Wheat germ - ABIN1311997
Millner, Doll, Cai, States, Hein: Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent. in Drug metabolism and disposition: the biological fate of chemicals 2011
Show all 2 Pubmed References
the results suggested that there was no association between NAT1 (zeige EIF4G2 Proteine)*10 allele and bladder cancer risk (meta-analysis).
identified a novel endogenous role for human NAT1 (zeige EIF4G2 Proteine) that might explain some of its effects in cancer cell growth and survival
N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.
The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR (zeige MTHFR Proteine) c.677C>T p.A222V(rs1801133), TP53 (zeige TP53 Proteine) c.215C>G p.R72P (rs1042522), NQO1 (zeige NQO1 Proteine) c.559C>T p.P187S (rs1800566), and NAT1 (zeige EIF4G2 Proteine) alleles imputed as fast acetylator genotypes. [meta-analysis]
NAT1 (zeige EIF4G2 Proteine) genotype affects thioguanine nucleotide levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs.
NAT1 (zeige EIF4G2 Proteine) genetic polymorphisms were found to be a risk factor for smokers in the Black population of South Africa with esophageal squamous cell carcinoma.
NAT1 (zeige EIF4G2 Proteine) has a role in the metabolic pathway of nicotine/cotinine and/or their metabolites.
We report that miR (zeige MLXIP Proteine)-1290 directly targets the NAT1 (zeige EIF4G2 Proteine) 3'-UTR and that NAT1 (zeige EIF4G2 Proteine) protein expression is correlated with improved OS of breast cancer patients.
Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine
Candidate gene NAT1 (zeige EIF4G2 Proteine) were elevated in male breast cancer biopsies compared to those from female patients without regard to Estrogen Receptors status.
these studies demonstrate that Nat1 (zeige EIF4G2 Proteine) deletion promotes reduced mitochondrial activity and is associated with ectopic lipid-induced insulin (zeige INS Proteine) resistance. These results provide a potential genetic link among mitochondrial dysfunction with increased ectopic lipid deposition, insulin (zeige INS Proteine) resistance, and type 2 diabetes.
Ca(2 (zeige CA2 Proteine)+)-dependent N-acyltransferase absolutely required Calcium for its activity and the activity was enhanced by phosphatidylserine.
Nat1 (zeige EIF4G2 Proteine) is involved in the translation of proteins that are required for cell differentiation.
This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver.
our results suggest that Nat1 (zeige EIF4G2 Proteine) deficiency results in mitochondrial dysfunction, which may constitute a mechanistic link between this gene and insulin (zeige INS Proteine) resistance .
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 (zeige NAT2 Proteine) defined by substrate specificity and inhibitor binding.(
In adipocytes, Nat1 (zeige EIF4G2 Proteine) silencing lowered insulin (zeige INS Proteine)-mediated glucose uptake, raised lipolysis, and decreased differentiation. Overexpression did the opposite. Nat1 (zeige EIF4G2 Proteine)(-) mice had high fasting blood glucose, insulin (zeige INS Proteine), and triglycerides and low insulin (zeige INS Proteine) sensitivity.
Transfection assays in mice using hydrodynamics-based procedure and reporter gene assay in a mouse cell line revealed that glucocorticoid-induced NAT (zeige BRD2 Proteine) gene expression is species dependent
NAT1 (zeige EIF4G2 Proteine) affects cell growth and morphology
Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase.
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.
N-acetyltransferase type 1
, arylamide acetylase 1
, arylamine N-acetyltransferase 1
, monomorphic arylamine N-acetyltransferase
, N(alpha)-acetyltransferase 15, NatA auxiliary subunit
, N-acetyl transferase 1, liver, blood
, N-acetyltransferase (arylamine N-acetyltransferase)
, N-acetyltransferase 1 (arylamine N-acetyltransferase)
, Arylamide acetylase 1
, Monomorphic arylamine N-acetyltransferase
, NAT1 9
, acetyltransferase AT-I
, arylamine acetyltransferase