Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteine (MLL)

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Zusätzlich bieten wir Ihnen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antikörper (53) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MLL 4297 Q03164
MLL 214162 P55200
Ratte MLL MLL 315606  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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HOST_Escherichia coli (E. coli) Human GST tag Recombinant MLL / HRX - SET protein gel. MLL / HRX - SET protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Anmelden zum Anzeigen 1 bis 2 Tage
$466.67
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MLL Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaktionspartnern

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaktionspartner

  1. we report two boys with novel KMT2A mutations from Chinese origin for the first time. They do not show one of the characteristic WDSTS phenotype, cubiti hypertrichosis. Instead, both of them had absent palmar proximal transverse crease. The feature was not linked to WDSTS patients previously. Our findings extend the WDSTS phenotypic spectrum.

  2. Whole exome sequencing allowed identifying a previously unreported de novo KMT2A missense mutation affecting the DNA binding domain of the methyltransferase. This finding expands the clinical phenotype associated with KMT2A mutations to include immunodeficiency and epilepsy as clinically relevant features for this disorder.

  3. MLL rearrangement is associated with infant acute lymphoblastic leukemia.

  4. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN Proteine) and DOT1L (zeige DOT1L Proteine) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (zeige DOT1L Proteine) for more effective treatment of MLL-rearranged leukemia.

  5. this indicates that DOT1L (zeige DOT1L Proteine) function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L (zeige DOT1L Proteine) inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  6. Studies demonstrate that histone methyl-transferase MLL1 coordinates with HIF1alpha (zeige HIF1A Proteine) and histone acetyltransferase p300 (zeige EP300 Proteine) and regulate hypoxia-induced HOTAIR expression. The hypoxia-induced upregulation of HOTAIR expression may contribute to its roles in tumorigenesis.

  7. MLL1 and MLL2 collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  8. MLL1, deposits H3K4me2 at CpG-dense regions that could serve as polycomb (zeige CBX2 Proteine) response elements.

  9. A patient was diagnosed with Wiedemann-Steiner syndrome based on identification of a novel de novo pathogenic variant in the KMT2A gene.

  10. MLL gene rearrangement is associated with acute lymphocytic leukemia.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaktionspartner

  1. Epigenomic profiling indicates an abnormal H3K79me2 pattern on MLL-fusion targeted genes, but the molecular mechanism underlying this epigenetic dependency is not well understood.

  2. NUP98 (zeige NUP98 Proteine)-HOXA9 (zeige HOXA9 Proteine) interacts with MLL via the NUP98 (zeige NUP98 Proteine) second FG repeat domain. In the absence of MLL (in knockout mice), NUP98 (zeige NUP98 Proteine)-HOXA9 (zeige HOXA9 Proteine)-induced cell immortalization and leukemogenesis are severely inhibited. MLL is important for the recruitment of NUP98 (zeige NUP98 Proteine)-HOXA9 (zeige HOXA9 Proteine) to the HOXA locus and for NUP98 (zeige NUP98 Proteine)-HOXA9 (zeige HOXA9 Proteine)-induced HOXA gene expression. MLL is crucial for NUP98 (zeige NUP98 Proteine)-HOXA9 (zeige HOXA9 Proteine) leukemia initiation.

  3. Atg5 (zeige ATG5 Proteine)-dependent autophagy contributes to the development of acute myeloid leukemia (zeige BCL11A Proteine) in an MLL-AF9 (zeige MLLT3 Proteine)-driven mouse model.

  4. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN Proteine) and DOT1L (zeige DOT1L Proteine) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (zeige DOT1L Proteine) for more effective treatment of MLL-rearranged leukemia.

  5. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  6. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  7. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  8. HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox (zeige MSH2 Proteine) Gene Expression Patterns and Mesoderm Lineage Development.

  9. MLL1 and DOT1L (zeige DOT1L Proteine) cooperate with meningioma-1 to induce acute myeloid leukemia (zeige BCL11A Proteine).

  10. Set1 role in cellular reprogramming and its interactions with Dpy30 (zeige DPY30 Proteine),Myc (zeige MYC Proteine),Sox2 (zeige SOX2 Proteine) and Ash2l (zeige ASH2L Proteine) reprogramming factors

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Protein Überblick

Protein Überblick

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A)
  • lysine (K)-specific methyltransferase 2A (Kmt2a)
  • 6430520K01 Protein
  • ALL-1 Protein
  • All1 Protein
  • Cxxc7 Protein
  • HRX Protein
  • HTRX1 Protein
  • mKIAA4050 Protein
  • Mll Protein
  • MLL/GAS7 Protein
  • Mll1 Protein
  • MLL1A Protein
  • TET1-MLL Protein
  • TRX1 Protein
  • WDSTS Protein

Bezeichner auf Proteinebene für MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPEZIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
Ausgewählte Anbieter für Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteine (MLL)
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