Myelin Basic Protein Proteine (MBP)

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. Zusätzlich bieten wir Ihnen Myelin Basic Protein Antikörper (200) und Myelin Basic Protein Kits (74) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MBP 4155 P02686
MBP 17196 P04370
MBP 24547 P02688
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Showing 10 out of 35 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$448.00
Details
Escherichia coli (E. coli) Human GST tag Myelin Basic Protein (MBP) (AA 134-304), (partial) protein (GST tag) 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$242.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
Details
Escherichia coli (E. coli) Kaninchen His tag,GST tag   50 μg Anmelden zum Anzeigen 15 bis 18 Tage
$380.00
Details
Hefe Carcharhinus obscurus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,262.33
Details
Hefe REACT_Little Skate His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,343.00
Details
Hefe REACT_Dogfish His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,343.00
Details
Hefe Heterodontus francisci His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,343.00
Details
Hefe Meerschweinchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,383.33
Details
Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,387.00
Details

MBP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

Weitere Proteine zu Myelin Basic Protein (MBP) Interaktionspartnern

Human Myelin Basic Protein (MBP) Interaktionspartner

  1. the interaction between the HLA-DRB1 (zeige HLA-DRB1 Proteine)*1501 allele and MBP (zeige MBL2 Proteine) gene may be considered as a predisposing factor in the development and pathogenesis of multiple sclerosis in the case of gene-gene interaction

  2. PAPP-A (zeige PAPPA Proteine) and ProMBP are associated with increased risk of death in heart failure patients.

  3. Studied potential use of myelin basic protein (MBP) as a biomarker in CSF (zeige CSF2 Proteine) of brain cancer patients. Results suggest that the presence of MBP (zeige MBL2 Proteine) in CSF (zeige CSF2 Proteine) may be considered as an indicator of the brain tumor development.

  4. t-PA (zeige PLAT Proteine) binds to Lys91 in the MBP (zeige MBL2 Proteine) NH2-terminal region and PLG (zeige PLG Proteine) binds to Lys122 in the MBP (zeige MBL2 Proteine) COOH-terminal region. This proximity promotes the activation of PLG (zeige PLG Proteine) by t-PA (zeige PLAT Proteine).

  5. Specific sites of post-translational modifications in multiple sclerosis patients are localized in two zones of MBP (zeige MBL2 Proteine) suggests that these regions may be involved in antigen recognition by the body's immune surveillance machinery

  6. Results provide novel insights into the role of genetic variation within the MBP (zeige MBL2 Proteine) gene predicting multiple sclerosis clinical course, both directly and by interaction with known environmental MS risk factors

  7. Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.

  8. This study observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1 (zeige NDEL1 Proteine)) mRNA levels in FEP patients compared with controls.

  9. myelin basic protein has a role in activating CD4 (zeige CD4 Proteine)+ and CD8 (zeige CD8A Proteine)+ T lymphocytes in multiple sclerosis

  10. B cells from relapsing-remitting multiple sclerosis patients produce TNFa (zeige TNF Proteine) and IL6 (zeige IL6 Proteine), and present MBP85-99 peptide

Mouse (Murine) Myelin Basic Protein (MBP) Interaktionspartner

  1. findings suggest that the acetylation and methylation of lysine on MBP are post-translational modifications associated with the neurological disability produced by EAE.

  2. The Mbp(+/-) mice exhibited defects of sensorimotor gating, as evidenced by reduced prepulse-inhibition, and a late-onset catatonia phenotype.

  3. The present study provides evidence for a novel L1-mediated function of MBP in the developing spinal cord and in the injured adult mammalian nervous system that leads to enhanced recovery after acute trauma.

  4. myelin basic protein (MBP) is inhibitory to both primitive neural stem cells and definitive neural stem cells derived colony formation.

  5. CNP (zeige CNP Proteine) directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP).

  6. to further characterize the mechanism regulating mbp transcription, study defined M3 structure/function relationships; multiple M3 regulatory element combinations were found to drive expression in oligodendrocytes and Schwann cells with a minimal 129 bp sequence conferring expression in oligodendrocytes throughout myelin elaboration, maintenance and repair

  7. Results show the expression of sncRNA715 in Schwann cells and its inverse correlation with Mbp mRNA in cultured cells and the sciatic nerve. Its inhibitory effect on MBP was confirmed in differentiating primary Schwann cells.

  8. Results suggest that GAL (zeige GAL Proteine) is a regulator of myelination, as demonstrated by MBP synthesis, and may be one of the myelination promoters

  9. Data indicate that 18.5 kDa myelin basic protein (MBP) segment upstream of the primary SH3-ligand is involved in interaction.

  10. Data suggest that prenatal alterations in expression of various fetal brain proteins (including up-regulation of Mbp) are associated with aberrant behavioral characteristics of transgenic mice that model autism-like behavior.

Zebrafish Myelin Basic Protein (MBP) Interaktionspartner

  1. Dynein/dynactin (zeige DCTN1 Proteine) is necessary for anterograde transport of Mbp mRNA in oligodendrocytes.

Pig (Porcine) Myelin Basic Protein (MBP) Interaktionspartner

  1. Concentrations of MBP did not increase after injury in all age groups

  2. results provide a detailed picture of the MBP-CaM interaction, including a 3D model of the complex between full-length proteins

  3. MBP-hydrolyzing antibodies may play an important role in multiple sclerosis pathogenesis

Cow (Bovine) Myelin Basic Protein (MBP) Interaktionspartner

  1. Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.

  2. Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase (zeige CDK7 Proteine) activities.

  3. trehalose completely avoid autocatalytic cleavage properties of MBP up to 4 days of incubation at 37 degrees C and pH 7.4.

  4. formation of an imine between inflammatory-derived aldehydes can lead to structural changes in MBP and a decrease in myelin stability

  5. results provide a detailed picture of the MBP-CaM interaction, including a 3D model of the complex between full-length proteins

  6. MBP can induce a dihydrocholesterol-dependent segregation of phases that can be further regulated by the electrolyte concentration in the subphase and the composition (type and proportion) of non-sterol lipids.

  7. Bovine MBP priming reduces expression of Foxp3 (zeige FOXP3 Proteine) via nitric oxide in inducible nitric oxide synthase (zeige NOS2 Proteine)-deficient mouse T cells.

  8. investigation of bovine myelin basic protein binding to triphosphoinositide

  9. There is a developmental regulation of posttranslationally modified forms of myelin basic protein into specific membrane microdomains.

  10. These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated high phosphorylation of SH-binding proteins, including MBP and tau protein.

Myelin Basic Protein (MBP) Protein Überblick

Protein Überblick

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

Genbezeichner und Symbole assoziert mit Myelin Basic Protein Proteine (MBP)

  • myelin basic protein (MBP)
  • myelin basic protein (Mbp)
  • myelin basic protein a (mbpa)
  • myelin basic protein (mbp)
  • myelin basic protein L homeolog (mbp.L)
  • C76307 Protein
  • cb274 Protein
  • fj33b11 Protein
  • golli-mbp Protein
  • Hmbpr Protein
  • mbp Protein
  • Mbps Protein
  • MGC115135 Protein
  • mld Protein
  • R75289 Protein
  • shi Protein
  • wu:fj33b11 Protein
  • wu:fq15b02 Protein
  • zgc:136630 Protein

Bezeichner auf Proteinebene für Myelin Basic Protein Proteine (MBP)

myelin A1 protein , myelin membrane encephalitogenic protein , myelin deficient , shiverer , Golli-Mbp; myelin basic protein , Golli-Mbp; myelin basic protein; myelin basic protein S , MBP S , myelin basic protein Golli-mbp , myelin basic protein S , myelin basic protein , Golli-mbp , 20 kDa microtubule-stabilizing protein , microtubule-stabilizing protein , Myelin A1 protein , Myelin P1 protein

GENE ID SPEZIES
4155 Homo sapiens
17196 Mus musculus
24547 Rattus norvegicus
326281 Danio rerio
396217 Gallus gallus
399102 Xenopus laevis
414286 Sus scrofa
455522 Pan troglodytes
476160 Canis lupus familiaris
549346 Xenopus (Silurana) tropicalis
618684 Bos taurus
734401 Xenopus laevis
100174122 Pongo abelii
101109407 Ovis aries
100731253 Cavia porcellus
100344447 Oryctolagus cuniculus
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