Mycn (MYCN) ELISA Kits

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Zusätzlich bieten wir Ihnen MYCN Antikörper (99) und MYCN Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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Top MYCN ELISA Kits auf antikoerper-online.de

Showing 4 out of 6 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
Details
Ratte 0.312-20 ng/mL   96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
$779.90
Details
Maus
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$946.00
Details
Huhn
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,095.60
Details

Weitere ELISA Kits für MYCN Interaktionspartner

Human Mycn (MYCN) Interaktionspartner

  1. Data indicate cross-talks between MYCN and beta-catenin (zeige CTNNB1 ELISA Kits) signalling, which repress normal beta-catenin (zeige CTNNB1 ELISA Kits) mediated transcriptional regulation.

  2. Data show that transcription factor activating enhancer binding protein-4 (TFAP4) is a direct transcriptional target of MYCN in neuroblastoma (zeige ARHGEF16 ELISA Kits) and that high levels of this transcription factor are associated with poor clinical outcome in this disease.

  3. data extend knowledge on roles of MCPIP1 (zeige ZC3H12A ELISA Kits) in our model and link the protein to regulation of expression and stability of MYCN through decrease of signaling via Akt (zeige AKT1 ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits) pathway.

  4. Data show that MYCN and its regulated microRNAs acted together to repress the tumor suppressor genes.

  5. Common genetic variation predisposes to different neuroblastoma (zeige ARHGEF16 ELISA Kits) genotypes, including the likelihood of somatic MYCN-amplification. [meta-analysis]

  6. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (zeige RB1 ELISA Kits) gene.

  7. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (zeige ARHGEF16 ELISA Kits), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (zeige ARHGEF16 ELISA Kits).

  8. Many prognostic signatures for neuroblastoma (zeige ARHGEF16 ELISA Kits) are confounded by MYCN amplification.

  9. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  10. miR (zeige MLXIP ELISA Kits)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (zeige CADM1 ELISA Kits), and an inverse correlation between miR (zeige MLXIP ELISA Kits)-21 and CADM1 (zeige CADM1 ELISA Kits) expression in vivo. MiR (zeige MLXIP ELISA Kits)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

Mouse (Murine) Mycn (MYCN) Interaktionspartner

  1. interactions of NF-kappaB (zeige NFKB1 ELISA Kits) and N-myc with GLT-1/EAAT2 (zeige SLC1A2 ELISA Kits) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.

  2. beta-catenin (zeige CTNNB1 ELISA Kits) cooperates with the transcription factor Myc (zeige MYC ELISA Kits) to activate the progenitor renewal program.

  3. we report the isolation and propagation of neuroblastoma (zeige ARHGEF16 ELISA Kits) sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma (zeige ARHGEF16 ELISA Kits) with MYCN amplification

  4. miR (zeige MLXIP ELISA Kits)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  5. the role of N-myc in mouse lens development, was examined.

  6. Using comparative genomic hybridization, authors found that NCC (zeige SLC12A3 ELISA Kits)-derived NBL (zeige NUMBL ELISA Kits) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (zeige NUMBL ELISA Kits) including 17q gain, 2p gain and loss of 1p36.

  7. a Mycn target gene encoding the miR (zeige MLXIP ELISA Kits) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  8. The findings reveal a PLK1 (zeige PLK1 ELISA Kits)-Fbw7 (zeige FBXW7 ELISA Kits)-Myc (zeige MYC ELISA Kits) signaling circuit that underlies tumorigenesis and validate PLK1 (zeige PLK1 ELISA Kits) inhibitors, alone or with Bcl2 (zeige BCL2 ELISA Kits) antagonists, as potential effective therapeutics for MYC (zeige MYC ELISA Kits)-overexpressing cancers.

  9. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (zeige MMRN1 ELISA Kits)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  10. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

Zebrafish Mycn (MYCN) Interaktionspartner

  1. In MYCN transgenic fish, Gab2 (zeige GAB2 ELISA Kits) overexpression activated the Shp2 (zeige PTPN11 ELISA Kits)-Ras (zeige RAB1A ELISA Kits)-Erk (zeige MAPK1 ELISA Kits) pathway, enhanced neuroblastoma (zeige ARHGEF16 ELISA Kits) induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 (zeige NF1 ELISA Kits) loss leads to aberrant activation of RAS (zeige RAB1A ELISA Kits) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (zeige ARHGEF16 ELISA Kits) in nf1 (zeige NF1 ELISA Kits)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (zeige NF1 ELISA Kits) mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN Antigen-Profil

Beschreibung des Gens

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Genbezeichner und Symbole assoziert mit Mycn (MYCN) ELISA Kits

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) Antikörper
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) Antikörper
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) Antikörper
  • olfactory receptor 8S1 (LOC515887) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor (mycn) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) Antikörper
  • bHLHe37 Antikörper
  • c-nmyc Antikörper
  • fb57a02 Antikörper
  • MODED Antikörper
  • mycn Antikörper
  • mycn-a Antikörper
  • mycn-b Antikörper
  • mycna Antikörper
  • MYCNOT Antikörper
  • N-myc Antikörper
  • Nmuc1 Antikörper
  • Nmyc Antikörper
  • Nmyc-1 Antikörper
  • nmyc1 Antikörper
  • ODED Antikörper
  • wu:fb57a02 Antikörper
  • XN-myc Antikörper
  • xN-myc1 Antikörper
  • XNmyc Antikörper
  • zgc:85706 Antikörper

Bezeichner auf Proteinebene für Mycn (MYCN) ELISA Kits

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPEZIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
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