Mycn (MYCN) ELISA Kits

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain.

list all ELISA KIts Gen GeneID UniProt
Anti-Human MYCN MYCN 4613 P04198
Anti-Maus MYCN MYCN 18109 P03966
Anti-Ratte MYCN MYCN 298894 Q63379
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Top MYCN ELISA Kits auf antikoerper-online.de

Showing 4 out of 6 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
Details
Ratte 0.312-20 ng/mL   96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
$779.90
Details
Maus
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$946.00
Details
Huhn
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,095.60
Details

Weitere ELISA Kits für MYCN Interaktionspartner

Human Mycn (MYCN) Interaktionspartner

  1. The combination of PD-L1 and HLA class I represents a novel prognostic biomarker for neuroblastoma. Pharmacologic inhibition of MYCN and MYC may be exploited to target PD-L1 and restore an efficient antitumor immunity in high-risk neuroblastoma.

  2. overexpression of MYCN promoted cell proliferation, and induced erythroid differentiation block and apoptosis resistance to cytotoxic agent. Knockdown of MYCN inhibited the expression of EZH2 (zeige EZH2 ELISA Kits), and then activated p21 (zeige CDKN1A ELISA Kits) expression through removal of H3K27me3 at the p21 (zeige CDKN1A ELISA Kits) promoter.

  3. MAX to MYCN ratio that can account for tumour progression and clinical outcome in neuroblastoma.

  4. MYCN expression is regulated by ZAR1 in neuroblastoma.

  5. The target of miR (zeige MLXIP ELISA Kits)-29b was predicted using miRanda, TargetScan and PicTar sofeware and authors also found MYCN was a direct target of miR (zeige MLXIP ELISA Kits)-29b in glioma cells and miR (zeige MLXIP ELISA Kits)-29b inhibited the proliferation of glioma cells via MYCN dependent way.

  6. eEF2K (zeige EEF2K ELISA Kits) protects MYCN overexpressing NB cells from ND in vitro and in vivo, highlighting this kinase as a critical mediator of the adaptive response of MYCN amplified NB cells to metabolic stress.

  7. Among 30 samples of brain tumor, 14 cases revealed MYCN amplification. High-protein expression of MYCN was also observed in 43.3% of patients. There was a significant correlation between MYCN gene amplification and protein expression, interestingly five case showed discrepancy between the gene amplification and protein expression.

  8. PRMT1 has a role in regulating MYCN in neuroblastoma

  9. N-myc levels appear to be modulated by the antagonistic interactions of both miR-17, as a negative regulator, and HuD, as a positive regulator in N-myc-amplified neuroblastoma cells.

  10. We also propose a model for the stabilization mechanism in which binding to Aurora-A (zeige AURKA ELISA Kits) alters how N-Myc interacts with SCF (zeige KITLG ELISA Kits)(FbxW7 (zeige FBXW7 ELISA Kits)) to disfavor the generation of Lys48-linked polyubiquitin (zeige UBB ELISA Kits) chains

Mouse (Murine) Mycn (MYCN) Interaktionspartner

  1. MYCN-promoted SGO1 (zeige SGOL1 ELISA Kits) transcription and SGO1 (zeige SGOL1 ELISA Kits) expression tended to be higher in MYCN- or MYC (zeige MYC ELISA Kits)-overexpressing cancers. Together, these findings indicate that SGO1 (zeige SGOL1 ELISA Kits) plays a role in the DNA damage response in interphase.

  2. interactions of NF-kappaB (zeige NFKB1 ELISA Kits) and N-myc with GLT-1/EAAT2 (zeige SLC1A2 ELISA Kits) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.

  3. beta-catenin (zeige CTNNB1 ELISA Kits) cooperates with the transcription factor Myc (zeige MYC ELISA Kits) to activate the progenitor renewal program.

  4. we report the isolation and propagation of neuroblastoma sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma with MYCN amplification

  5. miR (zeige MLXIP ELISA Kits)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  6. the role of N-myc in mouse lens development, was examined.

  7. Using comparative genomic hybridization, authors found that NCC-derived NBL tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL including 17q gain, 2p gain and loss of 1p36.

  8. a Mycn target gene encoding the miR (zeige MLXIP ELISA Kits) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  9. The findings reveal a PLK1 (zeige PLK1 ELISA Kits)-Fbw7 (zeige FBXW7 ELISA Kits)-Myc (zeige MYC ELISA Kits) signaling circuit that underlies tumorigenesis and validate PLK1 (zeige PLK1 ELISA Kits) inhibitors, alone or with Bcl2 (zeige BCL2 ELISA Kits) antagonists, as potential effective therapeutics for MYC (zeige MYC ELISA Kits)-overexpressing cancers.

  10. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (zeige MMRN1 ELISA Kits)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

Zebrafish Mycn (MYCN) Interaktionspartner

  1. In MYCN transgenic fish, Gab2 overexpression activated the Shp2-Ras-Erk pathway, enhanced neuroblastoma induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 (zeige NF1 ELISA Kits) loss leads to aberrant activation of RAS (zeige RAB1A ELISA Kits) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma in nf1 (zeige NF1 ELISA Kits)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (zeige NF1 ELISA Kits) mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN Antigen-Profil

Beschreibung des Gens

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Genbezeichner und Symbole assoziert mit Mycn (MYCN) ELISA Kits

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) Antikörper
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) Antikörper
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) Antikörper
  • olfactory receptor 8S1 (LOC515887) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor (mycn) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) Antikörper
  • bHLHe37 Antikörper
  • c-nmyc Antikörper
  • fb57a02 Antikörper
  • MODED Antikörper
  • mycn Antikörper
  • mycn-a Antikörper
  • mycn-b Antikörper
  • mycna Antikörper
  • MYCNOT Antikörper
  • N-myc Antikörper
  • Nmuc1 Antikörper
  • Nmyc Antikörper
  • Nmyc-1 Antikörper
  • nmyc1 Antikörper
  • ODED Antikörper
  • wu:fb57a02 Antikörper
  • XN-myc Antikörper
  • xN-myc1 Antikörper
  • XNmyc Antikörper
  • zgc:85706 Antikörper

Bezeichner auf Proteinebene für Mycn (MYCN) ELISA Kits

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPEZIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
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