anti-Mycn (MYCN) Antikörper

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Zusätzlich bieten wir Ihnen MYCN Kits (8) und MYCN Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
MYCN 298894 Q63379
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Top anti-MYCN Antikörper auf antikoerper-online.de

Showing 10 out of 98 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$318.45
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-MYCN Antibody Titration:  2.5ug/ml  Positive Control:  Human heart 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of MYCN antibody (C-term) (ABIN391590) in CEM cell line lysates (35 µg/lane). MYCN (arrow) was detected using the purified polyclonal antibody. Anti-MYCN Antibody (C-term) at 1:1000 dilution + CCRF-CEM whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 50 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Maus Unkonjugiert ChIP, CyTOF, FACS, GS, ICC, IF, IP, WB Immunocytochemistry/ Immunofluorescence: n-Myc Antibody (NMYC-1) [ABIN152254] - The n-Myc (NMYC-1) antibody was tested in NTERA2 cells at a 1:50 dilution against Dylight 488 (Green). Actin and nuclei were counterstained against Phalloidin 568 (Red) and DAPI (Blue), respectively. Western Blot: n-Myc Antibody (NMYC-1) [ABIN152254] - Western blot analysis of n-Myc expression in human heart tissue. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Human Maus Unkonjugiert ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) . Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of MYCN antibody (C-term) in CEM cell line lysates (35ug/lane). MYCN (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB Immunohistochemistry of paraffin-embedded mouse brain using MYCN antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.77
Details
Human Kaninchen Unkonjugiert ELISA, WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$390.50
Details

Am meisten referenzierte anti-MYCN Antikörper

  1. Human Monoclonal MYCN Primary Antibody für ChIP, CyTOF - ABIN152254 : Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. in The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal MYCN Primary Antibody für ICC, IF - ABIN256650 : Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. in Developmental cell 2005 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MYCN Primary Antibody für IF (p), IHC (p) - ABIN760676 : Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. in Oncotarget 2016 (PubMed)

  4. Human Polyclonal MYCN Primary Antibody für WB - ABIN391590 : Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. in Molecular cancer research : MCR 2015 (PubMed)

Weitere Antikörper gegen MYCN Interaktionspartner

Human Mycn (MYCN) Interaktionspartner

  1. MYCN levels are regulated transcriptionally by MYCNOS-01 (an alternative transcript of MYCNOS) in rhabdomyosarcoma and neuroblastoma (zeige ARHGEF16 Antikörper) cells.

  2. a MycN/CIP2A (zeige KIAA1524 Antikörper)-mediated cell-fate bias may reflect a possible mechanism underlying early priming of some aggressive forms of neuroblastoma (zeige ARHGEF16 Antikörper).

  3. CD133 expression and MYCN amplification induce chemoresistance and reduce average survival time in pediatric neuroblastoma (zeige ARHGEF16 Antikörper).

  4. Data indicate that inter-play between MYCN and the highly tumorigenic proteins which are upregulated in the malignant IMR-32 neuroblastoma (zeige ARHGEF16 Antikörper) cells may be fueling their aggressive behavior.

  5. these results suggest that MYCN serves as a prognostic biomarker and therapeutic target of ACR (zeige ACR Antikörper) for liver cancer stem cell in de novo Hepatocellular carcinoma.

  6. Alternative nonhomologous DNA end-joining pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation have been revealed in the process of neuroblastoma (zeige ARHGEF16 Antikörper) initiation in mice.

  7. High TrkA (zeige NTRK1 Antikörper) expression is one of the most powerful predictor of good prognosis in neuroblastoma (zeige ARHGEF16 Antikörper) and is associated with younger age, lower stage, and absence of MYCN amplification

  8. The combination of PD-L1 (zeige CD274 Antikörper) and HLA class I (zeige MICA Antikörper) represents a novel prognostic biomarker for neuroblastoma (zeige ARHGEF16 Antikörper). Pharmacologic inhibition of MYCN and MYC (zeige MYC Antikörper) may be exploited to target PD-L1 (zeige CD274 Antikörper) and restore an efficient antitumor immunity in high-risk neuroblastoma (zeige ARHGEF16 Antikörper).

  9. overexpression of MYCN promoted cell proliferation, and induced erythroid differentiation block and apoptosis resistance to cytotoxic agent. Knockdown of MYCN inhibited the expression of EZH2 (zeige EZH2 Antikörper), and then activated p21 (zeige CDKN1A Antikörper) expression through removal of H3K27me3 at the p21 (zeige CDKN1A Antikörper) promoter.

  10. MAX to MYCN ratio that can account for tumour progression and clinical outcome in neuroblastoma (zeige ARHGEF16 Antikörper).

Mouse (Murine) Mycn (MYCN) Interaktionspartner

  1. MYCN-promoted SGO1 (zeige SGOL1 Antikörper) transcription and SGO1 (zeige SGOL1 Antikörper) expression tended to be higher in MYCN- or MYC (zeige MYC Antikörper)-overexpressing cancers. Together, these findings indicate that SGO1 (zeige SGOL1 Antikörper) plays a role in the DNA damage response in interphase.

  2. interactions of NF-kappaB (zeige NFKB1 Antikörper) and N-myc with GLT-1/EAAT2 (zeige SLC1A2 Antikörper) promoter sequences was significantly elevated in the ipsi-lateral cortex of both adult and old Traumatic brain injury mice.

  3. beta-catenin (zeige CTNNB1 Antikörper) cooperates with the transcription factor Myc (zeige MYC Antikörper) to activate the progenitor renewal program.

  4. we report the isolation and propagation of neuroblastoma (zeige ARHGEF16 Antikörper) sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma (zeige ARHGEF16 Antikörper) with MYCN amplification

  5. miR (zeige MLXIP Antikörper)-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc.

  6. the role of N-myc in mouse lens development, was examined.

  7. Using comparative genomic hybridization, authors found that NCC (zeige SLC12A3 Antikörper)-derived NBL (zeige NUMBL Antikörper) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (zeige NUMBL Antikörper) including 17q gain, 2p gain and loss of 1p36.

  8. a Mycn target gene encoding the miR (zeige MLXIP Antikörper) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  9. The findings reveal a PLK1 (zeige PLK1 Antikörper)-Fbw7 (zeige FBXW7 Antikörper)-Myc (zeige MYC Antikörper) signaling circuit that underlies tumorigenesis and validate PLK1 (zeige PLK1 Antikörper) inhibitors, alone or with Bcl2 (zeige BCL2 Antikörper) antagonists, as potential effective therapeutics for MYC (zeige MYC Antikörper)-overexpressing cancers.

  10. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (zeige MMRN1 Antikörper)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

Zebrafish Mycn (MYCN) Interaktionspartner

  1. In MYCN transgenic fish, Gab2 (zeige GAB2 Antikörper) overexpression activated the Shp2 (zeige PTPN11 Antikörper)-Ras (zeige RAB1A Antikörper)-Erk (zeige MAPK1 Antikörper) pathway, enhanced neuroblastoma (zeige ARHGEF16 Antikörper) induction, and increased tumor penetrance.

  2. The authors demonstrate in zebrafish that nf1 (zeige NF1 Antikörper) loss leads to aberrant activation of RAS (zeige RAB1A Antikörper) signaling in MYCN-induced neuroblastomas that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is sufficient to suppress the acceleration of neuroblastoma (zeige ARHGEF16 Antikörper) in nf1 (zeige NF1 Antikörper)-deficient fish, but not the hypertrophy of sympathoadrenal cells in nf1 (zeige NF1 Antikörper) mutant embryos.

  3. At somitogenesis stages, nmyc1 expression was detected in the retina, midbrain, posterior hindbrain and presumptive spinal cord. It was also transcribed in the endoderm and its derivatives as well as in branchial arches.

MYCN Antigen-Profil

Protein Überblick

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Genbezeichner und Symbole assoziert mit anti-Mycn (MYCN) Antikörper

  • MYCN proto-oncogene, bHLH transcription factor (MYCN) Antikörper
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) Antikörper
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor (Mycn) Antikörper
  • olfactory receptor 8S1 (LOC515887) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor (mycn) Antikörper
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S) Antikörper
  • bHLHe37 Antikörper
  • c-nmyc Antikörper
  • fb57a02 Antikörper
  • MODED Antikörper
  • mycn Antikörper
  • mycn-a Antikörper
  • mycn-b Antikörper
  • mycna Antikörper
  • MYCNOT Antikörper
  • N-myc Antikörper
  • Nmuc1 Antikörper
  • Nmyc Antikörper
  • Nmyc-1 Antikörper
  • nmyc1 Antikörper
  • ODED Antikörper
  • wu:fb57a02 Antikörper
  • XN-myc Antikörper
  • xN-myc1 Antikörper
  • XNmyc Antikörper
  • zgc:85706 Antikörper

Bezeichner auf Proteinebene für anti-Mycn (MYCN) Antikörper

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPEZIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
Ausgewählte Anbieter für anti-MYCN (MYCN) Antikörper
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