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MCC is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. Zusätzlich bieten wir Ihnen MCC Antikörper (68) und viele weitere Produktgruppen zu diesem Protein an.
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The PDZ domain protein Mcc is a novel effector of non-canonical Wnt (zeige WNT2 Proteine) signaling during convergence and extension in zebrafish.
Study described a novel tumor suppressor function of MCC in the regulation of E-cadherin (zeige CDH1 Proteine) mediated cell-cell adhesion in colorectal cancer cells.
Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble (zeige SCRIB Proteine) PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 (zeige RPS6KA2 Proteine) and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 (zeige RPS6KA2 Proteine) = ribosomal protein S6 kinase 2 (zeige RPS6KA3 Proteine); MCC = mutated in colorectal cancer protein)
MCC might confer alterative genetic susceptibility to colorectal cancer in individuals with schizophrenia promising to shed more light on the relationship between schizophrenia and cancer progression.
Significantly, miR (zeige MLXIP Proteine)-4260 was increased in human colorectal cancer tissues with simultaneous downregulation of MCC and SMAD4 (zeige SMAD4 Proteine).
Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene (zeige RAB1A Proteine) in B cells
cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1 (zeige SIRT1 Proteine)
targeted by miR (zeige MLXIP Proteine)-494, which is overexpressed in hepatocellular carcinoma
MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex.
we have shown that promoter methylation of the APC (zeige APC Proteine) gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci.
Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer.
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
mutated in colorectal cancers
, colorectal mutant cancer protein