Mutated in Colorectal Cancers Proteine (MCC)

MCC is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. Zusätzlich bieten wir Ihnen MCC Antikörper (70) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MCC 4163 P23508
Maus MCC MCC 328949  
Ratte MCC MCC 307449  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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MCC Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu Mutated in Colorectal Cancers (MCC) Interaktionspartnern

Zebrafish Mutated in Colorectal Cancers (MCC) Interaktionspartner

  1. The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish.

Human Mutated in Colorectal Cancers (MCC) Interaktionspartner

  1. Alterations (deletion/methylation/mutation/expression) of MCC and CTNNBIP1 were analyzed in breast cancer patients (N=120) followed by expression/mutation analysis of beta-catenin. The alterations of MCC/CTNNBIP1 showed significant correlation with increased nuclear beta-catenin/p-beta-catenin(Y654) expression.

  2. Study described a novel tumor suppressor function of MCC in the regulation of E-cadherin mediated cell-cell adhesion in colorectal cancer cells.

  3. Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein)

  4. MCC might confer alterative genetic susceptibility to colorectal cancer in individuals with schizophrenia promising to shed more light on the relationship between schizophrenia and cancer progression.

  5. Significantly, miR-4260 was increased in human colorectal cancer tissues with simultaneous downregulation of MCC and SMAD4.

  6. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene in B cells

  7. cytoplasmic MCC-DBC1 interaction sequesters DBC1 away from the nucleus, thereby removing a brake on DBC1 nuclear targets, such as SIRT1

  8. targeted by miR-494, which is overexpressed in hepatocellular carcinoma

  9. MCC regulates lamellipodia formation by binding to Scrib and its downstream partner Myosin-IIB in a multiprotein complex.

  10. we have shown that promoter methylation of the APC gene does not extend to the neighbouring MCC gene in lung cancer, but LOH is found at both loci.

  11. Promoter methylated MCC is associated with inflammatory bowel disease in colorectal cancer.

  12. observed a significant association of the rs11283943 SNP with increased breast cancer risk in an Indian population

  13. MCC is a nuclear, beta-catenin-interacting protein that can act as a potential tumor suppressor in the serrated colorectal cancer pathway by inhibiting Wnt/beta-catenin signal transduction.

  14. Results identify MCC as a potential scaffold protein regulating cell movement and able to bind Scrib, beta-catenin and NHERF1/2.

Mouse (Murine) Mutated in Colorectal Cancers (MCC) Interaktionspartner

  1. Our results indicate that in sharp contrast to its tumor suppressive role in colorectal cancer, MCC functions as an oncogene in B cells

MCC Protein Überblick

Protein Überblick

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit MCC

  • mutated in colorectal cancers (MCC)
  • mutated in colorectal cancers (mcc)
  • mutated in colorectal cancers (Mcc)
  • D18Ertd451e Protein
  • E330037C19 Protein
  • MCC Protein
  • MCC1 Protein
  • RGD1561988 Protein

Bezeichner auf Proteinebene für MCC

mutated in colorectal cancers , colorectal mutant cancer protein

GENE ID SPEZIES
100064404 Equus caballus
415603 Gallus gallus
462002 Pan troglodytes
694270 Macaca mulatta
100015680 Monodelphis domestica
100216150 Xenopus (Silurana) tropicalis
100354734 Oryctolagus cuniculus
100473268 Ailuropoda melanoleuca
100537329 Danio rerio
4163 Homo sapiens
328949 Mus musculus
307449 Rattus norvegicus
611208 Canis lupus familiaris
616704 Bos taurus
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