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MUC20 encodes a member of the mucin protein family.
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Results suggest that MUC20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb2-Ras pathway.
High MUC20 expression is associated wit response to chemotherapy in esophageal squamous cell carcinoma.
increased gene expression of MUC16 (zeige MUC16 Proteine) and MUC20 was found in patients with remission ulcerative colitis
A combination of MUC13 (zeige MUC13 Proteine)/MUC20 expression was a potential prognostic marker for patients with ESCC, who received neoadjuvant chemotherapy followed by surgery.
Results suggest that MUC20 enhances aggressive behaviors of EOC cells by activating integrin beta1 signaling and provide novel insights into the role of MUC20 in ovarian cancer metastasis.
MUC20 is a novel transmembrane mucin (zeige SLC13A2 Proteine) expressed by the human corneal and conjunctival epithelia, and suggest that differential expression of MUC20 during differentiation has a role in maintaining ocular surface homeostasis.
MUC20 is expressed in recurrent colorectal neoplasms and may have a role in poor outcome
Reflux laryngitis is associated with down-regulation of mucin (zeige SLC13A2 Proteine) gene expression.
This study suggests that expression of MUC13 (zeige MUC13 Proteine) and MUC20 is not related to the susceptibility of piglets to enterotoxigenic E. coli-F4ac.
The full-length mRNA sequence of the porcine MUC20 gene was determined, revealing two MUC20 alternative transcripts differing in an 18-bp deletion in the open reading frame.
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in most individuals. The allele represented in the human reference assembly contains 12 copies. Multiple transcript variants encoding different isoforms have been found for this gene.
, transmembrane mucin MUC20S