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Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen MIXL1 Antikörper (46) und MIXL1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Findings support the existence of a novel MIXL1-c REL (zeige NFkBP65 Proteine) mediated survival axis in AML (zeige RUNX1 Proteine) that can be targeted by BMPR1 (zeige BMPR1A Proteine) inhibitors. (MIXL1- human gene, Mixl1- mouse ortholog, MIXL1- protein).
results demonstrate that Mixl1 and Flk1 play roles...during dimethyl sulfoxide-induced mesodermal specification in P19 cells.
Brachyury (zeige TBX1 Proteine) and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
These results demonstrate for a functional role for TGF-beta (zeige TGFB1 Proteine) ligands in regulation of mammalian Mixl1, identify FoxH1 (zeige FOXH1 Proteine) as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis.
MIXL1 protein is differentially expressed in non-Hodgkin lymphoma and Hodgkin lymphoma; findings suggest that MIXL1 overexpression may play a role in driving proliferatin or blocking differentiation in lymphoma oncogenesis
Targeted insertion in human embryonic stem cells of sequences encoding green fluorescent protein (GFP) into the locus of MIXL1, a gene transiently expressed in the primitive streak during embryogenesis.
In this study, we demonstrated that forced expression of Mix-like protein 1 (encoded by Mixl1) can be used to guide contribution of mouse embryonic stem cells to endodermal organs after blastocyst injection.
Embryonic localization of Mixl1 shows its co-localized with the early hematopoietic marker, Runx1 (zeige RUNX1 Proteine), in the allantois and visceral yolk sac (zeige ADCY10 Proteine) blood islands.
At later stages, in contrast with wild-type embryos, E7.5-8.0, Mixl1 knockout (KO) KO/KO (zeige KRT8 Proteine) embryos lacked morphologically recognizable midline structures such as the node and notochord.
These data support the hypothesis that Mixl1 directly regulates Pdgfralpha and Flk1 (zeige KDR Proteine) gene expression.
results strongly suggest that Gsc (zeige GSC Proteine) is a direct target gene of Mixl1 during embryogenesis.
required for the morphogenesis of axial mesoderm, the heart and the gut (zeige GUSB Proteine) during embryogenesis
Mixl1 is required for efficient haematopoiesis and BMP4 (zeige BMP4 Proteine)-induced ventral mesoderm patterning in differentiating ES cells
all mice reconstituted with Mixl1-transduced bone marrow developed fatal, transplantable acute myeloid leukemia (zeige BCL11A Proteine) with a mean latency period of 200 days
As goosecoid (zeige GSC Proteine) is itself induced in a Foxh1 (zeige FOXH1 Proteine)-dependent manner, we propose that Foxh1 (zeige FOXH1 Proteine) initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation
Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005
Mix1 homeobox-like 1 (Xenopus laevis)
, Mix-like homeobox protein 1
, MIX1 homeobox-like protein 1
, homeobox protein MIXL1
, homeodomain protein MIX
, mix.1 homeobox-like protein
, CMIX homeobox
, Mix1 homeobox-like 1