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ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). Zusätzlich bieten wir Ihnen ZAK Proteine (9) und ZAK Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 70 products:
Human Monoclonal ZAK Primary Antibody für IF, IHC (p) - ABIN565679
Cariolato, Cavin, Diviani: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in ?1-adrenergic receptor-induced p38 activation. in The Journal of biological chemistry 2011
Show all 3 Pubmed References
Human Polyclonal ZAK Primary Antibody für ICC, IF - ABIN4366552
Liu, McCleland, Stawiski, Gnad, Mayba, Haverty, Durinck, Chen, Klijn, Jhunjhunwala, Lawrence, Liu, Wan, Chopra, Yaylaoglu, Yuan, Ha, Gilbert, Reeder, Pau, Stinson, Stern, Manning, Wu, Neve et al.: Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. ... in Nature communications 2014
Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK (zeige MAPK1 Antikörper) and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers.
Recessive mutations in the kinase ZAK - novel cause of congenital myopathy.
ZAK is a key player in mammalian limb patterning in humans and mice.
ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers.
The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK (zeige MAPK1 Antikörper) pathway.
we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun (zeige JUN Antikörper)-NH(2)-kinase (JNK (zeige MAPK8 Antikörper)) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK)
MRK (zeige ICK Antikörper) is a novel RhoC (zeige RHOC Antikörper) effector that controls LPA (zeige APOA Antikörper)-stimulated cell invasion at least in part by regulating myosin dynamics, ERK (zeige EPHB2 Antikörper) and p38 (zeige CRK Antikörper)
The genes identified KTN1 (zeige KTN1 Antikörper), ROCK1 (zeige ROCK1 Antikörper), and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone
decrease of lung cancer cell proliferation by ZAK may involve the ERK (zeige EPHB2 Antikörper) and JNK (zeige MAPK8 Antikörper) pathways via an AP-1 (zeige FOSB Antikörper) transcription factor.
In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1 (zeige RPS6KA5 Antikörper), and show that MRK (zeige ICK Antikörper)-beta could also activate MSK1 (zeige RPS6KA5 Antikörper) through direct interaction.
Zak-/- mice demonstrate a distinct ribotoxic stress-associated phenotype in response to ricin.
Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6 (zeige ITGA6 Antikörper), Zak, Gpr155, and Mtx2 (zeige MTX2 Antikörper)) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.
PKNalpha (zeige PKN1 Antikörper) functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein (zeige HOMER1 Antikörper) for the p38gamma (zeige MAPK12 Antikörper) MAPK (zeige MAPK1 Antikörper) signaling pathway
Results show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF (zeige EGF Antikörper)-induced phosphorylation of histone H3 (zeige HIST3H3 Antikörper) at Ser28.
Mixed lineage kinase (zeige MAP3K12 Antikörper) 7 (MLK7), a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik), encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation.
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
mitogen-activated protein kinase kinase kinase MLT
, MLK-like mitogen-activated protein triple kinase
, human cervical cancer suppressor gene 4 protein
, mixed lineage kinase 7
, mixed lineage kinase with a leucine zipper and a sterile alpha motif
, mixed lineage kinase-related kinase MRK-beta
, MLK-related kinase
, leucine zipper- and sterile alpha motif kinase ZAK
, mixed lineage kinase-related kinase
, sterile alpha motif- and leucine zipper-containing kinase AZK
, sterile-alpha motif and leucine zipper containing kinase AZK