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The protein encoded by MAP4K4 is a member of the serine/threonine protein kinase family.
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the close proximity between AcSDKP and FGFR1 (zeige FGFR1 ELISA Kits) was essential for the suppression of TGFbeta (zeige TGFB1 ELISA Kits)/smad (zeige SMAD1 ELISA Kits) signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells.
RBM4-SRSF3 (zeige SRSF3 ELISA Kits)-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 (zeige MAPK8 ELISA Kits) signaling pathway.
these findings identify MAP4K4 as a novel MAPK/ERK (zeige MAPK1 ELISA Kits) pathway regulator in lung adenocarcinoma that is required for lung adenocarcinoma maintenance.
This report identifies HGK methylation/downregulation in T cells as a potential biomarker for non-obese type 2 diabetes
Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.
of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 gene is associated with T2DM in a Chinese Han population, and MAP4K4 gene variants may contribute to the risk toward the development of T2DM
Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D.
MAP4K4 promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells
miR (zeige MLXIP ELISA Kits)-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4
The results of the present study suggested that inhibition of MAP4K4 may be a therapeutic strategy for gastric cancer.
Blood endothelial Map4k4 promotes vascular dysfunction and impairs glucose homeostasis in adult animals, lymphatic endothelial Map4k4 is required to maintain lymphatic vascular integrity and regulate immune cell trafficking in obesity.
These results demonstrate that protein kinase (zeige CDK7 ELISA Kits) Map4k4 drives obesity-induced hyperinsulinemia and insulin (zeige INS ELISA Kits) resistance in part by promoting insulin (zeige INS ELISA Kits) secretion from beta cells in mice.
These results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis.
Mice with Map4k4 deleted in Myf5 (zeige MYF5 ELISA Kits)-positive tissues, including all skeletal muscles tested, were protected from obesity-induced glucose intolerance and insulin (zeige INS ELISA Kits) resistance.
HGK/MAP4K4 deficiency has a role in inducing TRAF2 stabilization and Th17 differentiation leading to insulin (zeige INS ELISA Kits) resistance
microtubules can deliver MAP4K4 toward focal adhesions through ending binding 2
MAP4K4 is essential for CD4 (zeige CD4 ELISA Kits)+ T cell proliferation and activation in vitro through suppressing PKC-theta (zeige PRKCQ ELISA Kits) activation.
Map4k4 inhibits adipose lipogenesis by suppression of Srebp-1 (zeige SREBF1 ELISA Kits) in an AMPK (zeige PRKAA1 ELISA Kits)- and mTOR (zeige FRAP1 ELISA Kits)-dependent but JNK (zeige MAPK8 ELISA Kits)-independent mechanism.
study identified single nucleotide polymorphisms at different locations of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) gene of cattle and several of them were significantly associated with the somatic cell score and other different milk traits
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
HPK/GCK-like kinase HGK
, MAPK/ERK kinase kinase kinase 4
, MEK kinase kinase 4
, Ste20 group protein kinase HGK
, hepatocyte progenitor kinase-like/germinal center kinase-like kinase
, nck-interacting kinase
, MEKKK 4
, NCK interacting kinase
, mitogen activated protein kinase kinase kinase kinase 4