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MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. Zusätzlich bieten wir Ihnen MAPK8IP1 Antikörper (80) und viele weitere Produktgruppen zu diesem Protein an.
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This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
mitogen-activated protein kinase 8 interacting protein 1
, c-Jun-amino-terminal kinase-interacting protein 1-like
, C-Jun-amino-terminal kinase-interacting protein 1
, JNK MAP kinase scaffold protein 1
, JNK-interacting protein 1
, mitogen activated protein kinase 8 interacting protein 1
, mitogen-activated protein kinase 8-interacting protein 1
, protein kinase, mitogen-activated 8 interacting protein
, JIP-1-related protein
, mitogen activated protein kinase 8 interacting protein
, PRKM8 interacting protein
, islet-brain 1
, islet brain 1