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MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. Zusätzlich bieten wir Ihnen MAPK8IP1 Antikörper (74) und und viele weitere Produktgruppen zu diesem Protein an.
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Phosphorylation of KLC1 (zeige KLC1 Proteine) at Thr466 increased in aged brains, and JIP1 binding to kinesin-1 decreased, suggesting that APP (zeige APP Proteine) transport is impaired by aging. Authors conclude that phosphorylation of KLC1 (zeige KLC1 Proteine) at Thr466 regulates the velocity of transport of APP (zeige APP Proteine) by kinesin-1 by modulating its interaction with JIP1b.
It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK (zeige MAPK8 Proteine) signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.
Enhanced fast-velocity and efficient high-frequency APP (zeige APP Proteine) anterograde transport observed in neurons are mediated by novel roles of JIP1b.
a simple yet modular mechanism for JIP1 scaffold assembly in mammals
There is a collaborative relationship between JIP1 and AKT (zeige AKT1 Proteine) that is required for axon growth and can be regulated by changes in neuronal activity.
identify plenty of SH3 (POSH (zeige SH3RF1 Proteine)) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 (zeige MAPK8 Proteine) activation in CD8 (zeige CD8A Proteine)(+) T cells.
The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP (zeige APP Proteine) transport in neurons.
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (zeige MAP3K11 Proteine) interaction with JIP1 scaffold protein (zeige HOMER1 Proteine) in cytokine-induced pancreatic beta cell death
JIP1 forms a trimetric complex with RBP-Jk (zeige RBPJ Proteine) and Notch1 (zeige NOTCH1 Proteine)-IC, prevents physical association between Notch1 (zeige NOTCH1 Proteine)-IC and RBP-Jk (zeige RBPJ Proteine), sequesters RBP-JK (zeige RBPJ Proteine) in the cytoplasm, and suppresses the Notch1 (zeige NOTCH1 Proteine) signaling pathway.
Data suggest that JIP1-mediated JNK (zeige MAPK8 Proteine) activation plays a critical role in metabolic stress regulation of the JNK (zeige MAPK8 Proteine) signaling pathway.
All binary complexes (KLC1 (zeige KLC1 Proteine):APP (zeige APP Proteine), KLC1 (zeige KLC1 Proteine):JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 (zeige KLC1 Proteine) and JIP1 may take part in APP (zeige APP Proteine) transport in Alzheimer's disease patients.
analysis of the role of JIP1 in APP (zeige APP Proteine) transport; knockdown of JIP1 did not affect either amyloid precursor protein (zeige APP Proteine) transport or amyloid-beta peptide production
Data show that small GTPase (zeige RACGAP1 Proteine) RALA (zeige rala Proteine) regulates formation of a JIP1 (C-Jun (zeige JUN Proteine)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (zeige MAPK8 Proteine) signaling toward FOXO4 (zeige FOXO4 Proteine) (forkhead box O transcription factor) in response to reactive oxygen species (ROS (zeige ROS1 Proteine)).
In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.
Data suggest that caspase 3 (zeige CASP3 Proteine)-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK (zeige MAPK8 Proteine) signalling during apoptotic cell death.
Data show that mechanical stress of urothelial cells activates in vivo JNK (zeige MAPK8 Proteine), as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 (zeige GJB2 Proteine) may be directly regulated by the AP-1 (zeige FOSB Proteine) complex.
results suggest that JIP (zeige SMAD4 Proteine)-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP (zeige APP Proteine), and that the JNK (zeige MAPK8 Proteine) signaling pathway may regulate the phosphorylation of this cargo protein through the JIP (zeige SMAD4 Proteine)-1b scaffold
JIP1 may act as an Akt1 (zeige AKT1 Proteine) scaffold, which regulates the enzymatic activity of Akt1 (zeige AKT1 Proteine) and can exert signaling effects independent of JNK (zeige MAPK8 Proteine) activity
JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
mitogen-activated protein kinase 8 interacting protein 1
, c-Jun-amino-terminal kinase-interacting protein 1-like
, C-Jun-amino-terminal kinase-interacting protein 1
, JNK MAP kinase scaffold protein 1
, JNK-interacting protein 1
, mitogen activated protein kinase 8 interacting protein 1
, mitogen-activated protein kinase 8-interacting protein 1
, protein kinase, mitogen-activated 8 interacting protein
, JIP-1-related protein
, mitogen activated protein kinase 8 interacting protein
, PRKM8 interacting protein
, islet-brain 1
, islet brain 1