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interacts with PPARalpha and with various nuclear hormone receptors [RGD, Feb 2006]..
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MECR is involved in mitochondrial fatty acid synthesis, and overexpression of this gene increases peroxisome proliferator-activated receptor alpha (PPARalpha (zeige PPARA ELISA Kits)) activity.
results suggest that mutations in MECR cause a distinct human disorder of the mitochondrial fatty acid synthesis pathway; the observation of decreased lipoylation raises the possibility of a potential therapeutic strategy
overexpression of MECR, the last step in the mitochondrial fatty acid synthesis (mtFASII) pathway, causes modulation of gene expression through the PPAR (zeige PPARA ELISA Kits) pathway.
The crystal structure of this dimeric enzyme (at 2.4 A resolution) suggests that the binding site for the recognition helix of the acyl carrier protein is in a groove between the two adjacent monomers.
The results showed a ventricular dilatation behind impaired heart function upon Mecr overexpression, concurrent with appearance of dysmorphic mitochondria
interacts with PPARalpha and with various nuclear hormone receptors
, homolog of yeast 2-enoyl thioester reductase
, mitochondrial 2-enoyl thioester reductase
, nuclear receptor binding factor 1
, nuclear receptor-binding factor 1
, trans-2-enoyl-CoA reductase, mitochondrial