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This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. Zusätzlich bieten wir Ihnen Mitochondrial Fission Factor Antikörper (64) und und viele weitere Produktgruppen zu diesem Protein an.
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expressions of TIA-1 (zeige TIA1 Proteine) and MFF were augmented in the cancerous liver tissues compared to the corresponding non-tumor tissues at mRNA and protein level, while the levels of miR (zeige MLXIP Proteine)-200a-3p and miR (zeige MLXIP Proteine)-27a/b were relatively lower in the cancerous liver tissues
We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations
membrane-anchored Mff differentially regulates various Drp1 (zeige CRMP1 Proteine) isoforms.
Data show that expression of MFF protein, miR-593-5p and BRCA1 protein correlates with cisplatin sensitivity and survival of tongue squamous cell carcinoma (TSCC).
loss of Mff results in failure of Parkin (zeige PARK2 Proteine) translocation and final clearance of damaged mitochondria
Mitochondrial fission factor (MFF) mRNA is a direct target of miR (zeige MLXIP Proteine)-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region.
MiD49 (zeige SMCR7 Proteine) and MiD51 (zeige SMCR7L Proteine) can act independently of Mff and Fis1 (zeige FIS1 Proteine) in Drp1 (zeige CRMP1 Proteine) recruitment and suggest that they provide specificity to the division of mitochondria.
TRAP1 (zeige TRAP1 Proteine) controls mitochondrial fusion/fission balance through Drp1 (zeige CRMP1 Proteine) and Mff expression.
PEX11 proteins attract both Mff and human Fis1 (hFis1 (zeige FIS1 Proteine)) to their site of action.
MFF over-expression results in extensive mitochondrial fragmentation, driving mitochondrial dysfunction. MFF fibroblasts undergo oxidative stress, with increased ROS (zeige ROS1 Proteine) production, and the onset of autophagy and mitophagy.
The cardiac ischemia/reperfusion injury - induced DUSP1 (zeige DUSP1 Proteine) deficiency promoted the activation of JNK (zeige MAPK8 Proteine) which upregulated the expression of the mitochondrial fission factor (Mff).
mitochondrial fission factor
MiD51 (zeige SMCR7L Proteine) can suppress Mff-dependent enhancement of Drp1 (zeige CRMP1 Proteine) GTPase (zeige RACGAP1 Proteine) activity.
Mff cannot bind to assembly-deficient mutants of Drp1 (zeige CRMP1 Proteine), suggesting that Mff selectively interacts with higher-order complexes of Drp1 (zeige CRMP1 Proteine).
These findings provide a mechanism wherein the multimeric states of both Mff and Drp1 (zeige CRMP1 Proteine) regulate their collaborative interaction.
Ablating Mfn1 (zeige MFN1 Proteine) eliminates the cardiac-related lethality of Mff knockout mice.
Mitochondrial fission factor has been identified as a new AMPK (zeige PRKAA1 Proteine) substrate.
This study reveals a novel model of mitochondrial fission regulation, which is composed of miR (zeige MLXIP Proteine)-761 and mitochondrial fission factor
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.
mitochondrial fission factor homolog B
, mitochondrial fission factor homolog A
, mitochondrial fission factor
, Uncharacterized protein C2orf33 homolog