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METTL3 encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. Zusätzlich bieten wir Ihnen METTL3 Antikörper (29) und METTL3 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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The role of METTL3 in pancreatic cancer cells drug resistance and radiation resistance.METTL3 was associated with mitogen-activated protein kinase cascades, ubiquitin-dependent process and RNA splicing and regulation of cellular process.
METTL3 is soluble and inactive while the catalytic center of METTL14 (zeige METTL14 Proteine) is degenerated and thus also inactive. In addition, the C-terminal RGG repeats of METTL14 (zeige METTL14 Proteine) are required for METTL3/14 activity by contributing to RNA substrate binding.
data define METTL3 as a regulator of a chromatin-based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia
methylation at m6A (zeige GPM6A Proteine) by METTL3/METTL14 (zeige METTL14 Proteine) facilitates the methylation of m5C by NSUN2 (zeige NSUN2 Proteine), and vice versa. NSUN2 (zeige NSUN2 Proteine)-mediated m5C and METTL3/METTL14 (zeige METTL14 Proteine)-mediated m6A (zeige GPM6A Proteine) methylation synergistically enhance p21 (zeige CDKN1A Proteine) expression at the translational level
loss of METTL3 leads to increased levels of phosphorylated AKT (zeige AKT1 Proteine), which contributes to the differentiation-promoting effects of METTL3 depletion. Overall, these results provide a rationale for the therapeutic targeting of METTL3 in myeloid leukemia (zeige BCL11A Proteine)
The structure reveals the heterodimeric architecture of the complex and donor substrate binding by METTL3. Structure-guided mutagenesis indicates that METTL3 is the catalytic subunit of the complex, whereas METTL14 (zeige METTL14 Proteine) has a degenerate active site and plays non-catalytic roles in maintaining complex integrity and substrate RNA binding.
For the methylation of adenosine in RNA, Mettl3 is the catalytically active subunit, while Mettl14 (zeige METTL14 Proteine) plays a structural role critical for substrate recognition.
METTL3 enhances mRNA translation through an interaction with the translation initiation machinery in lung adenocarcinoma cells.
miR (zeige MLXIP Proteine)-33a can attenuatenon-small-cell lung carcinoma cells proliferation via targeting to the 3'-untranslated region of METTL3 mRNA.
Structure of the METTL3-METTL14 (zeige METTL14 Proteine) complex
The data showed that Mettl3 is required for MyoD (zeige MYOD1 Proteine) mRNA expression in proliferative myoblasts.
Mettl3 was essential for male fertility and spermatogenesis.
Combined deletion of Mettl3 and Mettl14 (zeige METTL14 Proteine) in advanced germ cells with Stra8-GFPCre disrupts spermiogenesis, whereas mice with single deletion of either Mettl3 or Mettl14 (zeige METTL14 Proteine) in advanced germ cells show normal spermatogenesis.
this study identifies Mettl3, an N(6)-methyladenosine (m(6)A) transferase, as a regulator for terminating murine naive pluripotency.
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
N6-adenosine-methyltransferase 70 kDa subunit
, adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
, mRNA m(6)A methyltransferase
, methyltransferase-like protein 3
, m6a methyltransferase
, methyltransferase-like 3