anti-Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase (MTHFD2) Antikörper

MTHFD2 encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. Zusätzlich bieten wir Ihnen Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Proteine (8) und Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MTHFD2 17768 P18155
MTHFD2 10797 P13995
MTHFD2 680308  
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Top anti-Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Antikörper auf antikoerper-online.de

Showing 10 out of 48 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-MTHFD2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
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Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
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Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-MTHFD2 Antibody Titration: </b>1.25ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of MTHFD2 antibody (C-term) (ABIN391542) in NCI-H460 cell line lysates (35 µg/lane). MTHFD2 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human Colon carcinoma reacted with MTHFD2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$447.56
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Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
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Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ICC, IF, IP, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: 293T B: A431 , C: H1299 D: Hela E: Hep G2 , F: Molt-4 , G: Raji 10% SDS PAGE antibody diluted at 1:1000 IP Image Immunoprecipitation of MTHFD2 protein from 293T whole cell extracts using 5 μg of MTHFD2 antibody [N1C3], Western blot analysis was performed using MTHFD2 antibody [N1C3], EasyBlot anti-Rabbit IgG  was used as a secondary reagent. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details

MTHFD2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine)


Human ,
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Rat (Rattus)


Am meisten referenzierte anti-Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Antikörper

  1. Cow (Bovine) Polyclonal MTHFD2 Primary Antibody für WB - ABIN2782446 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal MTHFD2 Primary Antibody für ICC, IF - ABIN443140 : Moran, Trusk, Pry, Paz, Sidransky, Bacus: KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells. in Molecular cancer therapeutics 2014 (PubMed)

Weitere Antikörper gegen Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Interaktionspartner

Mouse (Murine) Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase (MTHFD2) Interaktionspartner

  1. Data suggest that Ad4BP (zeige NR5A1 Antikörper) plays role in regulation of intracellular NADPH (zeige FDXR Antikörper) concentration via transcription of Me1 (zeige ME1 Antikörper) and Mthfd2 genes in adrenocortical cells. (Ad4BP (zeige NR5A1 Antikörper) = nuclear receptor subfamily 5 group A member 1 (zeige NR5A1 Antikörper); Me1 (zeige ME1 Antikörper) = malic enzyme 1 (zeige ME1 Antikörper); Mthfd2 = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)

  2. A mutation in methylenetetrahydrofolate reductase (MTHFR (zeige MTHFR Antikörper)) gene, may contribute to the risk of both arterial and deep-vein thrombosis in patients with nephrotic syndrome.

Human Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase (MTHFD2) Interaktionspartner

  1. metabolic alterations in MCF7 cells observed as a consequence of MTHFD2 suppression

  2. crystal structure of MTHFD2 in complex with a substrate-based inhibitor and the enzyme cofactors NAD(+) and inorganic phosphate.

  3. Mechanistically, MYC (zeige MYC Antikörper) regulates the expression of MTHFD2, and MTHFD2 knockdown suppresses the TCA cycle.

  4. siRNA-mediated silencing of MTHFD2 inhibited migration, invasion and epithelial-mesenchymal transition progression in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) cell lines, but no obvious effects on cell proliferation, apoptosis or cell cycle distribution were detected. MTHFD2 is overexpressed in HCC (zeige FAM126A Antikörper), and is associated with poor prognosis and cellular features connected to metastatic disease.

  5. These findings suggest a previously unknown role for MTHFD2 in cancer cell proliferation, adding to its known function in mitochondrial folate metabolism.

  6. The highest scoring pathway is mitochondrial one-carbon metabolism and is centred on MTHFD2.

  7. Data indicate that methylenetetrahydrofolate dehydrogenase (NADP + -dependent) 2 (MTHFD2)was differentially expressed in breast cancer tissue, suggesting as a prognostic factor and a potential therapeutic target for future breast cancer treatments.

  8. Data indicate that the reduced vimentin (zeige VIM Antikörper) expression in response to EPHB4 (zeige EPHB4 Antikörper), WIPF2 (zeige WIPF2 Antikörper) and MTHFD2 silencing was observed at mRNA and protein levels.

Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase (MTHFD2) Antigen-Profil

Protein Überblick

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.

Genbezeichner und Symbole assoziert mit MTHFD2

  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase L homeolog (mthfd2.L) Antikörper
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) Antikörper
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (mthfd2) Antikörper
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like S homeolog (mthfd2l.S) Antikörper
  • methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (Mthfd2) Antikörper
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (Mthfd2) Antikörper
  • AW558851 Antikörper
  • NMDMC Antikörper
  • wu:fb38b11 Antikörper
  • wu:fe12e11 Antikörper
  • zgc:91891 Antikörper

Bezeichner auf Proteinebene für MTHFD2

bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial , methylene tetrahydrofolate dehydrogenase 2 , methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase , methylenetetrahydrofolate dehydrogenase 2 , NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase , methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase , methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase

GENE ID SPEZIES
432317 Xenopus laevis
459331 Pan troglodytes
100053990 Equus caballus
100170462 Xenopus (Silurana) tropicalis
100584729 Nomascus leucogenys
446641 Xenopus laevis
17768 Mus musculus
426126 Gallus gallus
10797 Homo sapiens
483107 Canis lupus familiaris
517539 Bos taurus
680308 Rattus norvegicus
100004977 Danio rerio
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