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The protein encoded by MSRB3 catalyzes the reduction of methionine sulfoxide to methionine.
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This characterization of GWAS-implicated MSRB3 protein expression in human hippocampus suggests that patterns of neuronal and vascular MsrB3 protein expression reflect or underlie pathology associated with Alzheimer disease.
Oncogene (zeige RAB1A ELISA Kits) induction in differentiated cells induces massive DNA damage, mammary stem cells are resistant, owing to a preemptive program driven by ZEB1 (zeige ZEB1 ELISA Kits) and MSRB3. The prevention of oncogene (zeige RAB1A ELISA Kits)-induced DNA damage precludes induction of the oncosuppressive p53 (zeige TP53 ELISA Kits)-dependent DNA-damage response, thereby increasing stem cells' intrinsic susceptibility to malignant transformation.
The data suggest that MsrB3 attenuates HO-1 (zeige HMOX1 ELISA Kits) induction by inhibiting reactive oxygen species production, endoplasmic reticulum stress, and Nrf2 (zeige GABPA ELISA Kits) activation.
MsrB3 plays an important role in cancer cell survival through the modulation of the intrinsic apoptosis pathway.
Taken together, our results suggest that MsrB3 plays a critical role in cancer cell apoptosis through the modulation of ER stress status.
MsrB3 deficiency activates the cell cycle inhibitors p21 (zeige CDKN1A ELISA Kits) and p27 (zeige PAK2 ELISA Kits).
DNA methylation shows genome-wide association of NFIX (zeige MLZE ELISA Kits), RAPGEF2 (zeige RAPGEF2 ELISA Kits) and MSRB3 with gestational age at birth.
these data provide evidence that the ER-type of MsrB3 plays an important role in protection against ER stress, suggesting that MsrB3 may be involved in the regulation of ER homeostasis.
Taken together, these data provide evidence that the ER type of MsrB (zeige MSRB2 ELISA Kits), MsrB3A, plays an important role in protection mechanisms against oxidative, cold and heat stresses and, moreover, in the regulation of fruit fly aging.
Results identified an antimicrobial peptide (zeige CAMP ELISA Kits) from the human methionine sulfoxide reductase B3 protein.
results provide insight into the role of MsrB3 in hearing function and bring us one step closer to hearing restoration as a fundamental therapy
data suggest that MsrB3 plays an essential role in maintaining the integrity of hair cells, possibly explaining the pathogenesis of DFNB74 deafness in humans caused by MSRB3 deficiency.
MsrB3 deficiency activates the cell cycle inhibitors p21 and p27 (zeige CDKN1B ELISA Kits).
data suggest that, in mice, MsrB3 is largely or exclusively an endoplasmic reticulum-resident protein, and that the reduction of methionine-R-sulfoxides in different cellular compartments is provided by individual MsrB (zeige MSRB2 ELISA Kits) isozymes. [MsrB3]
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula.
methionine-R-sulfoxide reductase B3
, methionine-R-sulfoxide reductase B3, mitochondrial
, Methionine-R-sulfoxide reductase B3, mitochondrial