anti-Melanophilin (MLPH) Antikörper

MLPH encodes a member of the exophilin subfamily of Rab effector proteins. Zusätzlich bieten wir Ihnen Melanophilin Kits (3) und Melanophilin Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MLPH 171531 Q91V27
MLPH 316620  
MLPH 79083 Q9BV36
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Top anti-Melanophilin Antikörper auf antikoerper-online.de

Showing 10 out of 59 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB <b>WB Suggested Anti-MLPH Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-MLPH <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Maus Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Immunohistochemistry analysis in human stomach tissue (Formalin-fixed, Paraffin-embedded) using Melanophilin / MLPH   Antibody (C-term), followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MLPH antibdy  for IHC; Clinical relevance has not been evaluated. Western blot analysis in A375 cell line lysates (35ug/lane) using Melanophilin / MLPH  Antibody (C-term). This demonstrates the MLPH antibody detected the MLPH protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: Melanophilin Antibody [NBP1-84765] - Staining of human prostate shows strong positivity in glandular cells. Immunohistochemistry-Paraffin: Melanophilin Antibody  - Staining of human stomach shows strong cytoplasmic and nuclear positivity in glandular cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Maus Ziege Unkonjugiert ICC, IF, IHC (p), ELISA, WB Immunohistochemistry-Paraffin: Melanophilin Antibody [ABIN268741] - Wild-type C57bl6 derived melanocytes were stained with (0.5ug/ml) and detected with Alexa568 conjugated donkey anti-sheep second antibodies. Brightfield image shows melanosome distribution. Data kindly provided by A N Hume, Imperial College. Western Blot: Melanophilin Antibody [ABIN268741] - Western blot staining (0.5ug/ml) of total melanocyte PNS (200ug per lane) of wild-type and leaden (Mlph null) mice. The upper band may be the stacking-separating gel interface. Data kindly provided by A N Hume, Imperial College 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IHC (p), WB MLPH Antibody (C-term)  western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the MLPH antibody detected the MLPH protein (arrow). MLPH Antibdy (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MLPH Antibdy (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Maus Ziege Unkonjugiert EIA, IF, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$455.40
Details
Maus Ziege Unkonjugiert IF, ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details
Maus Ziege Unkonjugiert ICC, IF, Pull-Down, ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details

MLPH Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine) , ,
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Rat (Rattus) , ,
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Am meisten referenzierte anti-Melanophilin Antikörper

  1. Mouse (Murine) Polyclonal MLPH Primary Antibody für ELISA, WB - ABIN184753 : Matesic, Yip, Reuss, Swing, OSullivan, Fletcher, Copeland, Jenkins: Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 4 Pubmed References

  2. Mouse (Murine) Polyclonal MLPH Primary Antibody für ICC, IF - ABIN268741 : Figueiredo, Wasmeier, Tarafder, Ramalho, Baron, Seabra: Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal MLPH Primary Antibody für WB - ABIN611185 : Hamza, Prohaska, Gitlin: Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal MLPH Primary Antibody für IHC, IHC (p) - ABIN4333829 : Gromov, Espinoza, Talman, Honma, Kroman, Timmermans Wielenga, Moreira, Gromova: FABP7 and HMGCS2 are novel protein markers for apocrine differentiation categorizing apocrine carcinoma of the breast. in PLoS ONE 2014 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen Melanophilin Interaktionspartner

Cow (Bovine) Melanophilin (MLPH) Interaktionspartner

  1. a frameshifting deletion in the melanophilin gene accounts for a distinctive coat color in Belgian Blue cattle

Rabbit Melanophilin (MLPH) Interaktionspartner

  1. A frameshift mutation within MLPH is responsible for the dilution of both eumelanic and pheomelanic pigmentations in rabbits.

  2. Two-exon skipping within MLPH is associated with coat color dilution in rabbits.

Mouse (Murine) Melanophilin (MLPH) Interaktionspartner

  1. The results showed that Rab27A (zeige RAB27A Antikörper)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (zeige RAB27A Antikörper) effector Slac2-a/melanophilin.

  2. Data show at the single-molecule level that melanophilin (Mlph) increases the number of processively moving myoVa (zeige MYO5A Antikörper) motors by 17-fold.

  3. Data suggest that Rab27a (zeige RAB27A Antikörper) and Rab27b (zeige RAB27B Antikörper) regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (zeige RAB27A Antikörper)/Mlph/MyoVa (zeige MYO5A Antikörper) regulating cortical actin stability upstream of Rab27a/b (zeige RAB27A Antikörper)/Munc13-4 (zeige UNC13D Antikörper)-dependent granule exocytosis.

  4. Slac2-a/melanophilin contains an N-terminal Slp (zeige SEPT9 Antikörper) homology domain (SHD (zeige SHD Antikörper)) (PMID: 11327731). The SHD (zeige SHD Antikörper) of Slac2-a specifically and directly binds the GTP (zeige AK3 Antikörper)-bound form of Rab27A (zeige RAB27A Antikörper) and Rab27B (zeige RAB27B Antikörper) (PMID: 11773082). The C-terminal domain directly binds myosin Va.

  5. The leaden gene product is required with Rab27a (zeige RAB27A Antikörper) to recruit myosin Va (zeige MYO5A Antikörper) to melanosomes in melanocytes

  6. myosin Va (zeige MYO5A Antikörper) binds to melanophilin and Rab27a (zeige RAB27A Antikörper)

  7. Melanophilin, the product of the leaden locus, is required for targeting of myosin-Va (zeige MYO5A Antikörper) to melanosomes

  8. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (zeige AK3 Antikörper)-bound form of Rab27A (zeige RAB27A Antikörper)

  9. Slac2-a organizes actin-based melanosome transport in cooperation with Rab27A, myosin Va, and actin

  10. cAMP stimulates the expression of Rab27a (zeige RAB27A Antikörper) and rapidly increases the interaction of the melanophilin/Slac2-a with actin

Human Melanophilin (MLPH) Interaktionspartner

  1. These results unravel a hidden link between AR and a functional putative PCa (zeige FLVCR1 Antikörper) risk SNP, whose allele alteration affects androgen regulation of its host gene MLPH.

  2. The results showed that Rab27A (zeige RAB27A Antikörper)(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A (zeige RAB27A Antikörper) effector Slac2-a/melanophilin.

  3. The pathologic defect in Griscelli syndrome 3 came from the MLPH R35W substitution, which induced aggregation of melanosomes in the perinuclear area of melanocytes because of failure to interact with RAB27A (zeige RAB27A Antikörper).

  4. Slac2-a/melanophilin contains an N-terminal Slp (zeige SEPT9 Antikörper) homology domain (SHD (zeige SHD Antikörper)) (PMID: 11327731). The SHD (zeige SHD Antikörper) of Slac2-a specifically and directly binds the GTP (zeige AK3 Antikörper)-bound form of Rab27A (zeige RAB27A Antikörper) and Rab27B (zeige RAB27B Antikörper) (PMID: 11773082). The C-terminus of Slac2-a directly binds myosin Va (zeige MYO5A Antikörper).

  5. links rab27a (zeige RAB27A Antikörper) and myosin Va (zeige MYO5A Antikörper) function in melanosome transport

  6. Melanophilin has a role in bridging Rab27a on melanosomes and myosin Va on actin filaments during melanosome transport.

  7. SHD1 of Slac2-a/melanophilin alone is both necessary and sufficient for high affinity specific recognition of the GTP (zeige AK3 Antikörper)-bound form of Rab27A (zeige RAB27A Antikörper)

  8. Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3 (zeige DNAJC21 Antikörper)) or a MYO5A (zeige MYO5A Antikörper) F-exon deletion (GS1 (zeige MYO5A Antikörper)).

  9. The C-terminus of Slac2-a/melanophilin contains a novel actin-binding site, which may be involved in capture of Rab27 (zeige RAB27A Antikörper)-containing organelles in the actin-enriched cell periphery.

Melanophilin (MLPH) Antigen-Profil

Protein Überblick

This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Genbezeichner und Symbole assoziert mit anti-Melanophilin (MLPH) Antikörper

  • melanophilin (MLPH) Antikörper
  • melanophilin (mlph) Antikörper
  • melanophilin (Mlph) Antikörper
  • 2210418F23Rik Antikörper
  • 5031433I09Rik Antikörper
  • AW228792 Antikörper
  • D1Wsu84e Antikörper
  • l(1)-3Rk Antikörper
  • l1Rk3 Antikörper
  • ln Antikörper
  • LOC100222096 Antikörper
  • MGC155106 Antikörper
  • Slac-2a Antikörper
  • SLAC2-A Antikörper

Bezeichner auf Proteinebene für anti-Melanophilin (MLPH) Antikörper

melanophilin , exophilin-3 , leaden protein , slaC2-a , slp homolog lacking C2 domains a , synaptotagmin-like protein 2a

GENE ID SPEZIES
424019 Gallus gallus
460048 Pan troglodytes
531343 Bos taurus
607077 Canis lupus familiaris
780791 Felis catus
100049680 Sus scrofa
100066385 Equus caballus
100145236 Xenopus (Silurana) tropicalis
100222096 Taeniopygia guttata
100272215 Ovis aries
100343360 Oryctolagus cuniculus
100590922 Nomascus leucogenys
171531 Mus musculus
316620 Rattus norvegicus
79083 Homo sapiens
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