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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen MMP12 Kits (66) und MMP12 Proteine (31) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 196 products:
Human Monoclonal MMP12 Primary Antibody für ELISA (Detection), IHC (fro) - ABIN786696
Chaudhuri, McSharry, Brady, Donnelly, Grierson, McGuinness, Jolly, Weir, Messow, Spears, Miele, Nocka, Crowther, Thompson, Brannigan, Lafferty, Sproule, Macnee, Connell, Murchison, Shepherd et al.: Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. ... in The Journal of allergy and clinical immunology 2012
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Human Monoclonal MMP12 Primary Antibody für ELISA (Detection), IHC (fro) - ABIN786697
Souissi, Billiet, Cuaz-Pérolin, Slimane, Rouis: Matrix metalloproteinase-12 gene regulation by a PPAR alpha agonist in human monocyte-derived macrophages. in Experimental cell research 2008
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Human Polyclonal MMP12 Primary Antibody für IF, IHC (p) - ABIN390136
Shapiro, Kobayashi, Ley: Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. in The Journal of biological chemistry 1993
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Human Polyclonal MMP12 Primary Antibody für IF (p), IHC (p) - ABIN735413
Kugo, Zaima, Onozato, Miyamoto, Hashimoto, Yanagimoto, Moriyama: Suppressive effects of dietary EPA-rich fish oil on the degradation of elastin fibers in the aortic wall in nicotine-administered mice. in Food & function 2017
Human Polyclonal MMP12 Primary Antibody für ICC, IF - ABIN441256
Damasdi, Kovacs, Farkas, Jakab, Kovacs: Down-regulation of Toll-like Receptor TLR4 Is Associated with HPV DNA Integration in Penile Carcinoma. in Anticancer research 2017
Human Polyclonal MMP12 Primary Antibody für IHC, WB - ABIN223402
Ikonomidis, Jones, Barbour, Stroud, Clark, Kaplan, Zeeshan, Bavaria, Gorman, Spinale, Gorman: Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. in The Journal of thoracic and cardiovascular surgery 2007
findings define a novel physiological function of Shp2 (zeige PTPN11 Antikörper) in TGF-beta1 (zeige TGFB1 Antikörper)/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder.
Mmp12 is expressed early following corneal epithelial injury with highest expression levels at 8 h after injury and lower expression levels at 4 and 8 days after injury. We investigated whether MMP12 has an effect on the rate of epithelial repair and cell migration using in vivo and in vitro scratch assays performed on WT and Mmp12(-/-) mice
MMP-12 produced by macrophages infiltrating into glomeruli contributed to the degradation of collagen type IV (zeige COL4 Antikörper) and fibronectin (zeige FN1 Antikörper).
MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.
These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.
study found significant increases of MMP-3 (zeige MMP3 Antikörper) and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection
The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 (zeige F2RL1 Antikörper) might be related to MMP-12 production.
MMP-12 up-regulation mediated by SARM (zeige SARM1 Antikörper)-TRIF (zeige RNF138 Antikörper) signaling pathway contributes to IFN-gamma (zeige IFNG Antikörper)-independent airway inflammation and AHR (zeige AHR Antikörper) post RSV infection in nude mice.
MMP-12 and MMP-13 (zeige MMP13 Antikörper) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
Post-MI, MMP-12i impaired CD44 (zeige CD44 Antikörper)-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function.
The results of this study demonstrate that the gene expression of MMP9 (zeige MMP9 Antikörper), MMP12, TIMP1 (zeige TIMP1 Antikörper) and TIMP2 (zeige TIMP2 Antikörper) was influenced by the addition of TGF-beta1 (zeige TGFB1 Antikörper). These results may be translated to chronic venous insufficiency framework and suggest involvement of TGF-beta1 (zeige TGFB1 Antikörper) in the vein wall pathology.
M4 macrophages are a possible source for HDAC9 (zeige HDAC9 Antikörper) and MMP12 expression in advanced human carotid plaques.
MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R (zeige CD200R1 Antikörper) surface levels. MMP12 production by these cells was induced by CSF2 (zeige CSF2 Antikörper), and treatment with a CD200R (zeige CD200R1 Antikörper) ligand reduced CSF2 (zeige CSF2 Antikörper)-induced MMP12 production. This novel association of the CD200 (zeige CD200 Antikörper)/CD200R (zeige CD200R1 Antikörper) pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression.
G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD (zeige ARCN1 Antikörper) in Bulgarian population
Data indicate that MMP1 (zeige MMP1 Antikörper), MMP12 and PPARG (zeige PPARG Antikörper) and hsa (zeige CD24 Antikörper)-miR (zeige MLXIP Antikörper)-31-5p, hsa (zeige CD24 Antikörper)-miR (zeige MLXIP Antikörper)-224-5p, and hsa (zeige CD24 Antikörper)-miR (zeige MLXIP Antikörper)-223-3p were able to distinguish tumors from NPT with high sensitivity and specificity.
Increased levels of MMP1 (zeige MMP1 Antikörper) and MMP12 on tumor-associated macrophages in the peripheral areas of dermatofibrosarcoma protuberance might contribute to local invasion
Matrix metalloprotease (MMP) regulation was the top pathway involved in gingival aging. MMP3 (zeige MMP3 Antikörper), MMP9 (zeige MMP9 Antikörper), MMP12, and MMP13 (zeige MMP13 Antikörper) were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B (zeige IL1B Antikörper)) expression.
We also found that MMP12 facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 may facilitate platelet activation through shedding of CEACAM1 (zeige CEACAM1 Antikörper).
There were no statistically significant differences in the distribution of MMP7 (zeige MMP7 Antikörper) -181 A/G and MMP12 -82 A/G genotype, allele, or haplotype frequencies between IRSA patients and controls, as well as patients' primary and secondary idiopathic recurrent spontaneous abortion
To conclude, Pseudomonas aeruginosa infection induced the expression of matrix metalloproteinases, and Pseudomonas aeruginosa type III secretion system appeared to be a key player in MMP-12 and MMP-13 (zeige MMP13 Antikörper) expression, which is further controlled by NF-kappaB (zeige NFKB1 Antikörper) signaling.
Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified MMP12 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
matrix metallopeptidase 12 (macrophage elastase)
, matrix metalloproteinase 12
, macrophage elastase
, macrophage metalloelastase
, matrix metalloproteinase-12
, matrix metalloproteinase 12 (macrophage elastase)
, macrophage metalloelastase MMP-12